Search Results - "Baccala, R."

Genomically Imposed and Somatically Modified Human Thymocyte VβGene Repertoires by Baccala, R., Kono, D. H., Walker, S., Balderas, R. S., Theofilopoulos, A. N.

“…The effect of thymic selection on the expressed human T-cell antigen receptor β-chain variable region (Vβ) gene repertoire was examined by using a multiprobe…”
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Two Murine Natural Polyreactive Autoantibodies are Encoded by Nonmutated Germ-Line Genes by Baccala, Roberto, Quang, Tuyen Vo, Gilbert, Michele, Ternynck, Therese, Avrameas, Stratis

“…Two monoclonal IgM natural autoantibodies (E7 and D23) obtained from the fusion of normal, nonimmunized, BALB/c mouse spleen cells and nonsecreting myeloma…”
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Type I interferons (alpha/beta) in immunity and autoimmunity by Theofilopoulos, Argyrios N, Baccala, Roberto, Beutler, Bruce, Kono, Dwight H

“…The significance of type I interferons (IFN-alpha/beta) in biology and medicine renders research on their activities continuously relevant to our understanding…”
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Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay by González-Quintial, R, Baccalá, R, Pope, R M, Theofilopoulos, A N

“…Identification of expanded clones engaged in immune and autoimmune responses is still imperfect, since they are often diluted by irrelevant cells expressing…”
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TLRs and interferons: a central paradigm in autoimmunity by Kono, Dwight H, Baccala, Roberto, Theofilopoulos, Argyrios N

“…Investigations into the pathogenesis of lupus have largely focused on abnormalities in components of the adaptive immune system. Despite important advances,…”
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Intracellular nucleic acid sensors and autoimmunity by Theofilopoulos, Argyrios N, Kono, Dwight H, Beutler, Bruce, Baccala, Roberto

“…A collection of molecular sensors has been defined by studies in the last decade that can recognize a diverse array of pathogens and initiate protective immune…”
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Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model by BACCALA, R, VANDEKERCKHOVE, B. A. E, JONES, D, KONO, D. H, RONCAROLO, M.-G, THEOFILOPOULOS, A. N

“…The ability to analyze T cell receptor (TCR) thymic repertoire shaping in humans by self and foreign ligands is hampered by the lack of suitable models. We…”
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The new paradigm of T-cell homeostatic proliferation-induced autoimmunity by Baccala, Roberto, Theofilopoulos, Argyrios N.

“…In lymphopenic conditions, T cells expand to re-establish homeostasis by a process dependent on self-peptide–MHC recognition and the availability of…”
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Interferons as pathogenic effectors in autoimmunity by Baccala, Roberto, Kono, Dwight H., Theofilopoulos, Argyrios N.

“…Interferons (IFNs) type‐1 (IFN α/β) and type‐II (IFN‐γ) are the most pleiotropic molecules in the intricate cytokine network. This dominance arises from three…”
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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice by Santiago-Raber, Marie-Laure, Baccala, Roberto, Haraldsson, Katarina M, Choubey, Divaker, Stewart, Timothy A, Kono, Dwight H, Theofilopoulos, Argyrios N

“…Indirect evidence suggests that type-I interferons (IFN-alpha/beta) play a significant role in the pathogenesis of lupus. To directly examine the contribution…”
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Sensors of the innate immune system: their link to rheumatic diseases by Theofilopoulos, Argyrios N, Gonzalez-Quintial, Rosana, Lawson, Brian R, Koh, Yi T, Stern, Michael E, Kono, Dwight H, Beutler, Bruce, Baccala, Roberto

“…By engaging innate immune receptors and inducing the production of proinflammatory cytokines, cells can sense and respond to danger signals. Defective…”
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Heterogeneous Vβ gene usage in mercury-induced immune disorders in rats by Fillion, J., Baccala, R., Kuhn, J., Druet, P., Bellon, B.

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Innate sensors for nucleic acids and lupus pathogenesis by Theofilopoulos, AN, Gonzalez-Quintial, R, Koh, Y-T, Baccala, R, Kono, DH

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T-cell repertoires in health and disease by Theofilopoulos, A N, Baccalà, R, González-Quintial, R, Kono, D H, Balderas, R S, Macphee, R, Duncan, S R, Roglic, M

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Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors by Baccala, Roberto, Witherden, Deborah, Gonzalez-Quintial, Rosana, Dummer, Wolfgang, Surh, Charles D, Havran, Wendy L, Theofilopoulos, Argyrios N

“…Among T cell subsets, gamma delta T cells uniquely display an Ag receptor-based tissue distribution, but what defines their preferential homing and homeostasis…”
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Application of a multiprobe RNase protection assay and junctional sequences to define V beta gene diversity in Sezary syndrome by Kono, DH, Baccala, R, Balderas, RS, Kovac, SJ, Heald, PW, Edelson, RL, Theofilopoulos, AN

“…Nineteen patients with mycosis fungoides/Sezary syndrome (MF/SZ), a malignancy of the mature helper T-cell phenotype (CD4+TCR alpha beta+), were screened for…”
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Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies by González-Quintial, R, Baccalà, R, Alzari, P M, Nahmias, C, Mazza, G, Fougereau, M, Avrameas, S

“…Previous studies have shown that the antibodies of the preimmune repertoire are able to bind to various auto- and xenoantigens including chemical haptens…”
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Red cell associated, naturally occurring anti-spectrin antibodies by Lutz, H U, Flepp, R, Stammler, P, Baccalà, R

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Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity by Lawson, Brian R, Baccala, Roberto, Song, Jianxun, Croft, Michael, Kono, Dwight H, Theofilopoulos, Argyrios N

“…A characteristic feature of systemic lupus erythematosus is the accumulation of activated/memory T and B cells. These G0/G1-arrested cells express high levels…”
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Human T helper cells specific for HIV reverse transcriptase: possible role in intrastructural help for HIV envelope-specific antibodies by Manca, F, Fenoglio, D, Valle, M T, Li Pira, G, Kunkl, A, Balderas, R S, Baccala, R G, Kono, D H, Ferraris, A, Saverino, D

“…Cooperation between B cells specific for an antigen exposed on a viral structure and T helper (Th) cells specific for an internal antigen, as demonstrated with…”
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