Search Results - "Baca, Miriam"

Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function by Jung, Min, Dourado, Michelle, Maksymetz, James, Jacobson, Amanda, Laufer, Benjamin I., Baca, Miriam, Foreman, Oded, Hackos, David H., Riol-Blanco, Lorena, Kaminker, Joshua S.

“…Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue homeostasis by sensing and initiating responses to stimuli. While most…”
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Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease by Le Pichon, Claire E, Meilandt, William J, Dominguez, Sara, Solanoy, Hilda, Lin, Han, Ngu, Hai, Gogineni, Alvin, Sengupta Ghosh, Arundhati, Jiang, Zhiyu, Lee, Seung-Hye, Maloney, Janice, Gandham, Vineela D, Pozniak, Christine D, Wang, Bei, Lee, Sebum, Siu, Michael, Patel, Snahel, Modrusan, Zora, Liu, Xingrong, Rudhard, York, Baca, Miriam, Gustafson, Amy, Kaminker, Josh, Carano, Richard A D, Huang, Eric J, Foreman, Oded, Weimer, Robby, Scearce-Levie, Kimberly, Lewcock, Joseph W

“…Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these…”
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Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease by Brendza, Robert, Gao, Xiaoying, Stark, Kimberly L., Lin, Han, Lee, Seung-Hye, Hu, Changyun, Cai, Hao, DiCara, Danielle, Hsiao, Yi-Chun, Ngu, Hai, Foreman, Oded, Baca, Miriam, Dohse, Monika, Fortin, Jean-Phillipe, Corpuz, Racquel, Seshasayee, Dhaya, Easton, Amy, Ayalon, Gai, Hötzel, Isidro, Chih, Ben

“…Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition…”
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Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of Type-2 inflammation over inhibition of either pathway alone by Ramirez-Carrozzi, Vladimir, PhD, Sambandam, Arivazhagan, PhD, Zhou, Meijuan, BS, Yan, Donghong, MD, Kang, Jing, BS, Wu, Xiumin, PhD, Suto, Eric, Baca, Miriam, BA, Austin, Cary, MD, PhD, Xu, Min, MD, PhD, Lee, Wyne P., BVS, Pappu, Rajita, PhD

“…Both IL-33 and IL-13 promote Type-2 inflammation and are implicated in the pathogenesis of asthma. Blocking both pathways together leads to a greater…”
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Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity by Weber, Martin, Min, Sang-Won, Truong, Tom, Hung, Jeffrey, Dale, Stephanie, Reichelt, Mike, Ubhayakar, Savita, Cain-Hom, Carol, Baca, Miriam, Jiang, Zhiyu, Li, Qingling, Brendza, Robert, Lin, Han, Kung, Chung, Forrest, William F., Quiason-Huynh, Cristine, Sandoval, Wendy, Chen, Buyun, Deng, Yuzhong, Easton, Amy, Foreman, Oded, Sene, Abdoulaye, Bingol, Baris

“…Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop…”
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The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins by Suryamohan, Kushal, Krishnankutty, Sajesh P., Guillory, Joseph, Jevit, Matthew, Schröder, Markus S., Wu, Meng, Kuriakose, Boney, Mathew, Oommen K., Perumal, Rajadurai C., Koludarov, Ivan, Goldstein, Leonard D., Senger, Kate, Dixon, Mandumpala Davis, Velayutham, Dinesh, Vargas, Derek, Chaudhuri, Subhra, Muraleedharan, Megha, Goel, Ridhi, Chen, Ying-Jiun J., Ratan, Aakrosh, Liu, Peter, Faherty, Brendan, de la Rosa, Guillermo, Shibata, Hiroki, Baca, Miriam, Sagolla, Meredith, Ziai, James, Wright, Gus A., Vucic, Domagoj, Mohan, Sangeetha, Antony, Aju, Stinson, Jeremy, Kirkpatrick, Donald S., Hannoush, Rami N., Durinck, Steffen, Modrusan, Zora, Stawiski, Eric W., Wiley, Kristen, Raudsepp, Terje, Kini, R. Manjunatha, Zachariah, Arun, Seshagiri, Somasekar

“…Snakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive…”
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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1 by Solon, Margaret, Ge, Nianfeng, Hambro, Shannon, Haller, Susan, Jiang, Jian, Baca, Miriam, Preston, Jessica, Maltzman, Allie, Wickliffe, Katherine E., Liang, Yuxin, Reja, Rohit, Nickles, Dorothee, Newton, Kim, Webster, Joshua D.

“…Necroptosis is a lytic form of cell death that is mediated by the kinase RIPK3 and the pseudokinase MLKL when caspase-8 is inhibited downstream of death…”
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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung by Fuji, Reina N, Flagella, Michael, Baca, Miriam, Baptista, Marco A S, Brodbeck, Jens, Chan, Bryan K, Fiske, Brian K, Honigberg, Lee, Jubb, Adrian M, Katavolos, Paula, Lee, Donna W, Lewin-Koh, Sock-Cheng, Lin, Tori, Liu, Xingrong, Liu, Shannon, Lyssikatos, Joseph P, O'Mahony, Jennifer, Reichelt, Mike, Roose-Girma, Merone, Sheng, Zejuan, Sherer, Todd, Smith, Ashley, Solon, Margaret, Sweeney, Zachary K, Tarrant, Jacqueline, Urkowitz, Alison, Warming, Søren, Yaylaoglu, Murat, Zhang, Shuo, Zhu, Haitao, Estrada, Anthony A, Watts, Ryan J

“…Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However,…”
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A randomized, placebo‐controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER) by Austin, Cary D., Gonzalez Edick, Melissa, Ferrando, Ronald E., Solon, Margaret, Baca, Miriam, Mesh, Kathryn, Bradding, Peter, Gauvreau, Gail M., Sumino, Kaharu, FitzGerald, J. Mark, Israel, Elliot, Bjermer, Lief, Bourdin, Arnaud, Arron, Joseph R., Choy, David F., Olsson, Julie K., Abreu, Francis, Howard, Monet, Wong, Kit, Cai, Fang, Peng, Kun, Putnam, Wendy S., Holweg, Cécile T.J., Matthews, John G., Kraft, Monica, Woodruff, Prescott G.

“…Background The anti‐interleukin 13 (IL‐13) monoclonal antibody lebrikizumab improves lung function in patients with moderate‐to‐severe uncontrolled asthma, but…”
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A Randomized, Placebo‐Controlled Trial Evaluating Effects of Lebrikizumab on Airway Eosinophilic Inflammation and Remodeling in Uncontrolled Asthma (CLAVIER) by Austin, Cary D., Edick, Melissa Gonzalez, Ferrando, Ronald E., Solon, Margaret, Baca, Miriam, Mesh, Kathryn, Bradding, Peter, Gauvreau, Gail M., Sumino, Kaharu, Fitzgerald, Mark, Israel, Eliott, Bjermer, Leif, Bourdin, Arnaud, Arron, Joseph R., Choy, David F., Olsson, Julie K., Abreu, Francis D., Howard, Monet D., Wong, Kit D., Cai, Fang D., Peng, Kun D., Putman, Wendy S., Holweg, Cécile T. J., Matthews, John G., Kraft, Monica, Woodruff, Prescott G.

“…Abstract only Background The anti–interleukin 13 (IL‐13) monoclonal antibody lebrikizumab improves lung function in patients with moderate‐severe uncontrolled…”
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BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats by Weber, Martin, Wu, Tiffany, Meilandt, William J., Dominguez, Sara L., Solanoy, Hilda O., Maloney, Janice A., Ngu, Hai, Baca, Miriam, Kung, Chung, Lima, Lisa, Earr, Timothy K., Fleck, Daniel, Shields, Shannon D., Forrest, William F., Foreman, Oded, Warming, Søren, Watts, Ryan J., Scearce-Levie, Kimberly

“…Assessing BACE1 (β-site APP cleaving enzyme 1) knockout mice for general health and neurological function may be useful in predicting risks associated with…”
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Critical role of activation induced cytidine deaminase in Experimental Autoimmune Encephalomyelitis by Sun, Yonglian, Peng, Ivan, Senger, Kate, Hamidzadeh, Kajal, Reichelt, Mike, Baca, Miriam, Yeh, Ronald, Lorenzo, Maria N., Sebrell, Andrew, Dela Cruz, Christopher, Tam, Lucinda, Corpuz, Racquel, Wu, Jiansheng, Sai, Tao, Roose-Girma, Merone, Warming, Søren, Balazs, Mercedesz, Gonzalez, Lino C., Caplazi, Patrick, Martin, Flavius, Devoss, Jason, Zarrin, Ali A.

“…Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder caused by chronic inflammation and demyelination within the central nervous system (CNS)…”
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