Search Results - "Babych, Margaryta"

Amyloid self‐assembling peptides: Potential applications in nanovaccine engineering and biosensing by Al‐Halifa, Soultan, Babych, Margaryta, Zottig, Ximena, Archambault, Denis, Bourgault, Steve

“…Living organisms are an inestimable source of inspiration for the design of biomaterials and nanostructures for medical and technological applications…”
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Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity by Fortier, Mathilde, Côté-Cyr, Mélanie, Nguyen, Vy, Babych, Margaryta, Nguyen, Phuong Trang, Gaudreault, Roger, Bourgault, Steve

“…The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is…”
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Harnessing the Activation of Toll-Like Receptor 2/6 by Self-Assembled Cross-β Fibrils to Design Adjuvanted Nanovaccines by Al-Halifa, Soultan, Zottig, Ximena, Babych, Margaryta, Côté-Cyr, Mélanie, Bourgault, Steve, Archambault, Denis

“…Protein fibrils characterized with a cross-β-sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of…”
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Compartmentalized processing of catechols during mussel byssus fabrication determines the destiny of DOPA by Priemel, Tobias, Palia, Ranveer, Babych, Margaryta, Thibodeaux, Christopher J., Bourgault, Steve, Harrington, Matthew J.

“…Inspired largely by the role of the posttranslationally modified amino acid dopa (DOPA) in mussel adhesion, catechol functional groups have become commonplace…”
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Converting the Amyloidogenic Islet Amyloid Polypeptide into a Potent Nonaggregating Peptide Ligand by Side Chain-to-Side Chain Macrocyclization by Babych, Margaryta, Garelja, Michael L., Nguyen, Phuong Trang, Hay, Debbie L., Bourgault, Steve

“…The islet amyloid polypeptide (IAPP), also known as amylin, is a hormone playing key physiological roles. However, its aggregation and deposition in the…”
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Development of a novel fluorescence assay for studying lipid bilayer perturbation induced by amyloidogenic peptides using cell plasma membrane vesicles by Sebastiao, Mathew, Babych, Margaryta, Quittot, Noé, Kumar, Kiran, Arnold, Alexandre A, Marcotte, Isabelle, Bourgault, Steve

“…Numerous pathophysiological conditions are associated with the misfolding and aggregation of proteins into insoluble amyloid fibrils. The mechanisms by which…”
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Cell surface glycosaminoglycans exacerbate plasma membrane perturbation induced by the islet amyloid polypeptide by Quittot, Noé, Fortier, Mathilde, Babych, Margaryta, Nguyen, Phuong Trang, Sebastiao, Mathew, Bourgault, Steve

“…Glycosaminoglycans (GAGs) are long and unbranched anionic heteropolysaccharides that have been associated with virtually all amyloid deposits. Soluble sulfated…”
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Engineering and evaluation of amyloid assemblies as a nanovaccine against the Chikungunya virus by Babych, Margaryta, Bertheau-Mailhot, Geneviève, Zottig, Ximena, Dion, Jessica, Gauthier, Laurie, Archambault, Denis, Bourgault, Steve

“…The design of nanoparticles exposing a high density of antigens constitutes a promising strategy to address safety concerns of conventional life-attenuated…”
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Identification of a novel TLR5 agonist derived from the P97 protein of Mycoplasma hyopneumoniae by Gauthier, Laurie, Babych, Margaryta, Segura, Mariela, Bourgault, Steve, Archambault, Denis

“…By modulating specific immune responses against antigens, adjuvants are used in many vaccine preparations to enhance protective immunity. The C-terminal domain…”
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Guiding the Morphology of Amyloid Assemblies by Electrostatic Capping: from Polymorphic Twisted Fibrils to Uniform Nanorods by Zottig, Ximena, Al‐Halifa, Soultan, Babych, Margaryta, Quittot, Noé, Archambault, Denis, Bourgault, Steve

“…Peptides that self‐assemble into cross‐β‐sheet amyloid structures constitute promising building blocks to construct highly ordered proteinaceous materials and…”
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Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes by Babych, Margaryta, Nguyen, Phuong Trang, Côté-Cyr, Mélanie, Kihal, Nadjib, Quittot, Noé, Golizeh, Makan, Sleno, Lekha, Bourgault, Steve

“…The accumulation of insoluble amyloids in the pancreatic islets is a pathological hallmark of type II diabetes and correlates closely with the loss of β-cell…”
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