Search Results - "Babunovic, Gregory H"

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis by Bryson, Bryan D., Rosebrock, Tracy R., Tafesse, Fikadu G., Itoh, Christopher Y., Nibasumba, Armel, Babunovic, Gregory H., Corleis, Bjorn, Martin, Constance, Keegan, Caroline, Andrade, Priscila, Realegeno, Susan, Kwon, Douglas, Modlin, Robert L., Fortune, Sarah M.

“…Variability in bacterial sterilization is a key feature of Mycobacterium tuberculosis (Mtb) disease. In a population of human macrophages, there are…”
Get full text

CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A by Babunovic, Gregory H, DeJesus, Michael A, Bosch, Barbara, Chase, Michael R, Barbier, Thibault, Dickey, Amy K, Bryson, Bryan D, Rock, Jeremy M, Fortune, Sarah M

“…Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can kill the infecting bacterium when appropriately activated. To…”
Get full text

High-Throughput CRISPR Screens To Dissect Macrophage- Shigella Interactions by Lai, Yong, Cui, Liang, Babunovic, Gregory H, Fortune, Sarah M, Doench, John G, Lu, Timothy K

“…Shigellosis causes most diarrheal deaths worldwide, particularly affecting children. invades and replicates in the epithelium of the large intestine, eliciting…”
Get full text

A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis by O'Hara, Joanne M, Wakabayashi, Shoko, Siddiqi, Noman, Cheung, Elaine, Babunovic, Gregory H, Thompson, Claudette M, Lu, Ying-Jie, Rubin, Eric J, Malley, Richard, Zhang, Fan

“…Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. To date, the mainstay of vaccination involves the use of Mycobacterium bovis…”
Get full text

Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria by Sakatos, Alexandra, Babunovic, Gregory H, Chase, Michael R, Dills, Alexander, Leszyk, John, Rosebrock, Tracy, Bryson, Bryan, Fortune, Sarah M

“…There is increasing evidence that phenotypically drug-resistant bacteria may be important determinants of antibiotic treatment failure. Using high-throughput…”
Get full text

Tuberculosis treatment failure associated with evolution of antibiotic resilience by Liu, Qingyun, Zhu, Junhao, Dulberger, Charles L, Stanley, Sydney, Wilson, Sean, Chung, Eun Seon, Wang, Xin, Culviner, Peter, Liu, Yue J, Hicks, Nathan D, Babunovic, Gregory H, Giffen, Samantha R, Aldridge, Bree B, Garner, Ethan C, Rubin, Eric J, Chao, Michael C, Fortune, Sarah M

“…The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229 (…”
Get full text