Search Results - "Babu Shubha, Priya"
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Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization
Published in Biochemical pharmacology (01-01-2018)“…[Display omitted] Autophagy is a major protein degradation pathway capable of upholding cellular metabolism under nutrient limiting conditions, making it a…”
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Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells
Published in Molecules (Basel, Switzerland) (29-04-2022)“…A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell…”
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Purification and biochemical characterization of a novel secretory dipeptidyl peptidase IV from porcine serum
Published in Molecular and cellular biochemistry (01-08-2020)“…Purification of DPP-IV enzyme from porcine serum, is presented in this study for the first time. The high molecular weight DPP-IV from porcine serum was…”
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Novel synthesis of N-unsubstituted imidazoles via the cycloaddition of N-(tert-butylsulfinyl)imines and TosMIC
Published in Tetrahedron letters (02-04-2020)“…[Display omitted] •Facile and efficient approach for the synthesis of 4(5)-aryl-1H-imidazoles.•Transition-metal-free, mild reaction conditions with operational…”
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Hemostatically potent small molecular weight serine protease from Maclura spinosa (Roxb. ex Willd.) accelerates healing of subcutaneous dermal wounds in Swiss albino mice
Published in Biológia (2020)“…Latex of Maclura spinosa has been used by Kollamalayali tribal community of Western Ghats for curdling of milk. In our previous study we have reported the…”
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Development of Novel Indole and Coumarin Derivatives as Antibacterial Agents That Target Histidine Kinase in S. aureus
Published in Applied Microbiology (Basel) (17-10-2023)“…Heterocyclic compounds can specifically regulate bacterial development by targeting specific bacterial enzymes and metabolic pathways. The ESKAPE pathogens are…”
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Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells
Published in Biomedicines (10-01-2023)“…Small molecules are being used to inhibit cyclin dependent kinase (CDK) enzymes in cancer treatment. There is evidence that CDK is a drug-target for cancer…”
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Development of a New Arylamination Reaction Catalyzed by Polymer Bound 1,3-(Bisbenzimidazolyl) Benzene Co(II) Complex and Generation of Bioactive Adamanate Amines
Published in Catalysts (01-11-2020)“…We herein report the preparation and characterization of an inexpensive polymer supported 1,3-bis(benzimidazolyl)benzeneCo(II) complex [PS-Co(BBZN)Cl2] as a…”
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Serine protease from Indian Cobra venom: its anticoagulant property and effect on human fibrinogen
Published in Toxin reviews (02-01-2022)“…An unusual low molecular weight serine protease (NnP28) has been purified from Indian Cobra (Naja naja) venom from the western region of the Indian…”
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A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade
Published in Apoptosis (London) (2017)“…Condensed-bicyclic 4,6-substituted1,2,4-triazolo-1,3,4-thiadiazole derivatives (CBTT) have been shown to possess a wide spectrum of pharmacological activities…”
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Development of Novel Pyridine and Pyrimidine Clubbed Bisindoles as Inhibitors of AKT Pathway
Published in ChemistrySelect (Weinheim) (18-07-2024)“…Indoles and their derivatives have long been studied for their anticancer properties. Breast cancer has been treated using indole‐3‐carbinol, Indirubins, and…”
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A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNF[alpha] by abrogating NF-[kappa]B activation cascade
Published in Apoptosis (London) (01-01-2017)“…Condensed-bicyclic 4,6-substituted1,2,4-triazolo-1,3,4-thiadiazole derivatives (CBTT) have been shown to possess a wide spectrum of pharmacological activities…”
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Neutralization of Haemorrhagic Activity of Viper Venoms by 1‐(3‐Dimethylaminopropyl)‐1‐(4‐Fluorophenyl)‐3‐Oxo‐1,3‐Dihydroisobenzofuran‐5‐Carbonitrile
Published in Basic & clinical pharmacology & toxicology (01-10-2011)“…: Viper envenomation undeniably induces brutal local manifestations such as haemorrhage, oedema and necrosis involving massive degradation of extracellular…”
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