Search Results - "Babu Lankadasari, Manendra"
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Regulatory role of SphK1 in TLR7/9‐dependent type I interferon response and autoimmunity
Published in The FASEB journal (01-03-2020)“…Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report…”
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Targeting acid ceramidase enhances antitumor immune response in colorectal cancer
Published in Journal of advanced research (01-11-2024)“…[Display omitted] •Acid ceramidase (ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine and its role in…”
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Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy
Published in Pharmacological research (01-04-2018)“…[Display omitted] Inflammation is one of the major causative factor of cancer and chronic inflammation is involved in all the major steps of cancer initiation,…”
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TAMing pancreatic cancer: combat with a double edged sword
Published in Molecular cancer (30-03-2019)“…Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early…”
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Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression
Published in Scientific reports (24-10-2017)“…Colorectal cancer is currently the third leading cause of cancer related deaths. There is considerable interest in using dietary intervention strategies to…”
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Enhanced expression of histone chaperone APLF associate with breast cancer
Published in Molecular cancer (26-03-2018)“…DNA damage-specific histone chaperone Aprataxin PNK-like factor (APLF) regulates mesenchymal-to-epithelial transition (MET) during cellular reprogramming. We…”
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Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer
Published in Biomolecules (Basel, Switzerland) (29-04-2021)“…Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated…”
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Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine
Published in Theranostics (01-01-2018)“…Pancreatic cancer is associated with poor prognosis with a 5-year survival rate of less than 6%. Approximately 90% of pancreatic cancer patients harbor somatic…”
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Abrogation of Pancreatic Cancer Using a Brain Malady Drug
Published in The FASEB journal (01-04-2019)“…Pancreatic cancer is the fourth preeminent cause of cancer‐related deaths with a poor prognosis. Desmoplasia and drug resistance are few of the pivotal hurdles…”
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Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus
Published in The FASEB journal (01-06-2019)“…ABSTRACT Systemic lupus erythematosus is an autoimmune disease characterized by overproduction of type 1 IFN that causes multiple organ dysfunctions…”
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