Search Results - "Babu, Sunanda R."

Extreme Genetic Risk for Type 1A Diabetes by Aly, Theresa A., Ide, Akane, Jahromi, Mohamed M., Barker, Jennifer M., Fernando, Maria S., Babu, Sunanda R., Yu, Liping, Miao, Dongmei, Erlich, Henry A., Fain, Pamela R., Barriga, Katherine J., Norris, Jill M., Rewers, Marian J., Eisenbarth, George S.

“…Type 1A diabetes (T1D) is an autoimmune disorder the risk of which is increased by specific HLA DR/DQ alleles [e.g., DRB1*03DQB1*0201 (DR3) or…”
Get full text

Analysis of Single Nucleotide Polymorphisms Identifies Major Type 1A Diabetes Locus Telomeric of the Major Histocompatibility Complex by Aly, Theresa A, Baschal, Erin E, Jahromi, Mohamed M, Fernando, Maria S, Babu, Sunanda R, Fingerlin, Tasha E, Kretowski, Adam, Erlich, Henry A, Fain, Pamela R, Rewers, Marian J, Eisenbarth, George S

“…Analysis of Single Nucleotide Polymorphisms Identifies Major Type 1A Diabetes Locus Telomeric of the Major Histocompatibility Complex Theresa A. Aly 1 , 2 ,…”
Get full text

HLA-DPB10402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB10201/DR4-DQB10302 DAISY Population by BASCHAL, Erin E, ALY, Theresa A, REWERS, Marian J, EISENBARTH, George S, BABU, Sunanda R, FERNANDO, Maria S, LIPING YU, DONGMEI MIAO, BARRIGA, Katherine J, NORRIS, Jill M, NOBLE, Janelle A, ERLICH, Henry A

“…HLA-DPB1*0402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population Erin E. Baschal 1 , Theresa A…”
Get full text

Association of Non-HLA Genes With Type 1 Diabetes Autoimmunity by STECK, Andrea K, BUGAWAN, Teodorica L, REWERS, Marian J, VALDES, Ana Maria, EMERY, Lisa M, BLAIR, Alan, NORRIS, Jill M, REDONDO, Maria J, BABU, Sunanda R, ERLICH, Henry A, EISENBARTH, George S

“…Association of Non-HLA Genes With Type 1 Diabetes Autoimmunity Andrea K. Steck 1 , Teodorica L. Bugawan 2 , Ana Maria Valdes 2 , Lisa M. Emery 3 , Alan Blair 2…”
Get full text

Stepwise or Linear Decrease in Penetrance of Type 1 Diabetes With Lower-Risk HLA Genotypes Over the Past 40 Years by STECK, Andrea K, ARMSTRONG, Taylor K, BABU, Sunanda R, EISENBARTH, George S

“…The objective of this study was to test if the proportion of new-onset diabetic subjects with the HLA-DR3/4-DQB1*0302 genotype is decreasing over time. We…”
Get full text

Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype by Barker, Jennifer M., Triolo, Taylor M., Aly, Theresa A., Baschal, Erin E., Babu, Sunanda R., Kretowski, Adam, Rewers, Marian J., Eisenbarth, George S.

“…Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype Potential for Rapid Screening Jennifer M. Barker , Taylor M. Triolo ,…”
Get full text

“Extended” A1, B8, DR3 Haplotype Shows Remarkable Linkage Disequilibrium but Is Similar to Nonextended Haplotypes in Terms of Diabetes Risk by IDE, Akane, BABU, Sunanda R, ROBLES, David T, TIANBAO WANG, ERLICH, Henry A, BUGAWAN, Teodorica L, REWERS, Marian, FAIN, Pamela R, EISENBARTH, George S

“…“Extended” A1, B8, DR3 Haplotype Shows Remarkable Linkage Disequilibrium but Is Similar to Nonextended Haplotypes in Terms of Diabetes Risk Akane Ide , Sunanda…”
Get full text

Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype : Potential for Rapid Screening by BARKER, Jennifer M, TRIOLO, Taylor M, ALY, Theresa A, BASCHAL, Erin E, BABU, Sunanda R, KRETOWSKI, Adam, REWERS, Marian J, EISENBARTH, George S

“…People with the HLA genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (DR3/4-DQ8) are at the highest risk of developing type 1 diabetes. We…”
Get full text

Multi-SNP analysis of MHC region : Remarkable conservation of HLA-A1-B8-DR3 haplotype by ALY, Theresa A, ELLER, Elise, IDE, Akane, GOWAN, Katherine, BABU, Sunanda R, ERLICH, Henry A, REWERS, Marian J, EISENBARTH, George S, FAIN, Pamela R

“…Technology has become available to cost-effectively analyze thousands of single nucleotide polymorphisms (SNPs). We recently confirmed by genotyping a small…”
Get full text

Haplotype Analysis Discriminates Genetic Risk for DR3-Associated Endocrine Autoimmunity and Helps Define Extreme Risk for Addison’s Disease by Baker, Peter R, Baschal, Erin E, Fain, Pam R, Triolo, Taylor M, Nanduri, Priyaanka, Siebert, Janet C, Armstrong, Taylor K, Babu, Sunanda R, Rewers, Marian J, Gottlieb, Peter A, Barker, Jennifer M, Eisenbarth, George S

“…Context: Multiple autoimmune disorders (e.g. Addison’s disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of…”
Get full text

Juvenile diabetes by Babu, Sunanda R, Eisenbarth, George S

“…Despite the large number of loci, only three have appreciable odds ratios, the major histocompatibility complex (MHC), the insulin gene and a molecule…”
Get full text

Dominant Suppression of Addison's Disease Associated with HLA-B15 by Baker, Peter R, Baschal, Erin E, Fain, Pam R, Nanduri, Priyaanka, Triolo, Taylor M, Siebert, Janet C, Armstrong, Taylor K, Babu, Sunanda R, Rewers, Marian J, Gottlieb, Peter A, Barker, Jennifer M, Eisenbarth, George S

“…Context: Autoimmune Addison's disease (AD) is the major cause of primary adrenal failure in developed nations. Autoantibodies to 21-hydroxylase (21OH-AA) are…”
Get full text

Association of the PTPN22/LYP gene with type 1 diabetes by Steck, Andrea K, Liu, Si-Yang, McFann, Kim, Barriga, Katherine J, Babu, Sunanda R, Eisenbarth, George S, Rewers, Marian J, She, Jin-Xiong

“…Objectives:  The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non‐receptor type 22…”
Get full text

Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex by BASCHAL, Erin E., SARKAR, Suparna A., BOYLE, Theresa A., SIEBERT, Janet C., JASINSKI, Jean M., GRABEK, Katharine R., ARMSTRONG, Taylor K., BABU, Sunanda R., FAIN, Pamela R., STECK, Andrea K., REWERS, Marian J., EISENBARTH, George S.

“…Background:  We recently reported an association between Type 1 diabetes and the telomeric major histocompatibility complex (MHC) single nucleotide…”
Get full text

ICA512 autoantibody radioassay by GIANANI, R, RABIN, D. U, VERGE, C. F, LIPING YU, BABU, S. R, PIETROPAOLO, M, EISENBARTH, G. S

“…As part of a general program of screening islet expression libraries we have identified a clone from a lambda gt11 human islet expression library that reacts…”
Get full text

Celiac Disease and HLA in a Bedouin Kindred by Eller, Elise, Vardi, Pnina, Babu, Sunanda R., Bugawan, Teodorica L., Erlich, Henry A., Yu, Liping, Fain, Pamela R.

“…We report the prevalence of celiac disease (CD) and its relationship with other autoimmune diseases and HLA haplotypes in a Bedouin kindred. Of 175 individuals…”
Get full text

Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies by Robles, David T, Eisenbarth, George S, Wang, Tianbao, Erlich, Henry A, Bugawan, Teodorica L, Babu, Sunanda R, Barriga, Kathy, Norris, Jill M, Hoffman, Michelle, Klingensmith, Georgeanna, Yu, Liping, Rewers, Marian

“…A total of 21,000 general population newborns (NECs) and 693 young siblings-offspring of patients with type 1A diabetes (SOCs) were class II genotyped and 293…”
Get full text

Caspase 7 Is a Positional Candidate Gene for IDDM 17 in a Bedouin Arab Family by BABU, SUNANDA R., BAO, FEI, ROBERTS, CHRISTINE M., MARTIN, ALLISON K., GOWAN, KATHERINE, EISENBARTH, GEORGE S., FAIN, PAMELA R.

“…: The IDDM 17 locus was mapped to an 8‐cM interval at chromosome 10q25.1 based on linkage in a large Bedouin Arab family with 19 affected relatives. Caspase 7…”
Get full text

Establishment of Native Insulin-Negative NOD Mice and the Methodology to Distinguish Specific Insulin Knockout Genotypes and a B:16 Alanine Preproinsulin Transgene by NAKAYAMA, MAKI, MORIYAMA, HIROAKI, ABIRU, NORIO, BABU, SUNANDA R., SIKORA, KAMILA, LI, MARCELLA, MIAO, DONGMEI, HUTTON, JOHN C., ELLIOTT, JOHN F., EISENBARTH, GEORGE S.

“…: We hypothesize that NOD mice without native insulin, but with an altered insulin B:9‐23 sequence, will be completely protected from diabetes/insulitis if…”
Get full text

Genetic prediction of autoimmunity: Initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4–DQ8 relatives of patients with type 1A diabetes by Aly, Theresa A., Ide, Akane, Humphrey, Kurt, Barker, Jennifer M., Steck, Andrea, Erlich, Henry A., Yu, Liping, Miao, Dongmei, Redondo, Maria J., McFann, Kim, Roberts, Christine M., Babu, Sunanda R., Norris, Jill M., Eisenbarth, George S., Rewers, Marian J.

“…In this study, the combined risk for expressing anti-islet autoantibodies and type 1A diabetes (T1D) was prospectively examined in 85 sampled relatives who had…”
Get full text