Search Results - "Babu, Madan M."

The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease by Babu, M Madan

“…In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid…”
Get more information

Mechanisms of signalling and biased agonism in G protein-coupled receptors by Wootten, Denise, Christopoulos, Arthur, Marti-Solano, Maria, Babu, M. Madan, Sexton, Patrick M.

“…G protein-coupled receptors (GPCRs) are the largest group of cell surface receptors in humans that signal in response to diverse inputs and regulate a plethora…”
Get full text

Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions by Torrent, Marc, Chalancon, Guilhem, de Groot, Natalia S, Wuster, Arthur, Madan Babu, M

“…Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the abundance of which can affect the decoding rate and translation…”
Get more information

GPCR activation mechanisms across classes and macro/microscales by Hauser, Alexander S., Kooistra, Albert J., Munk, Christian, Heydenreich, Franziska M., Veprintsev, Dmitry B., Bouvier, Michel, Babu, M. Madan, Gloriam, David E.

“…Two-thirds of human hormones and one-third of clinical drugs activate ~350 G-protein-coupled receptors (GPCR) belonging to four classes: A, B1, C and F…”
Get full text

Data-driven design of orthogonal protein-protein interactions by Malinverni, Duccio, Babu, M Madan

“…Engineering protein-protein interactions to generate new functions presents a challenge with great potential for many applications, ranging from therapeutics…”
Get more information

Common activation mechanism of class A GPCRs by Zhou, Qingtong, Yang, Dehua, Wu, Meng, Guo, Yu, Guo, Wanjing, Zhong, Li, Cai, Xiaoqing, Dai, Antao, Jang, Wonjo, Shakhnovich, Eugene I, Liu, Zhi-Jie, Stevens, Raymond C, Lambert, Nevin A, Babu, M Madan, Wang, Ming-Wei, Zhao, Suwen

“…Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for…”
Get full text

Molecular signatures of G-protein-coupled receptors by Venkatakrishnan, A. J., Deupi, Xavier, Lebon, Guillaume, Tate, Christopher G., Schertler, Gebhard F., Babu, M. Madan

“…A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts…”
Get full text

A community effort to bring structure to disorder by Lang, Benjamin, Babu, M. Madan

“…With protein structure prediction recently getting a seismic boost in accuracy, hopes are also up to better predict unstructured protein regions that can adopt…”
Get full text

Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable by Yu, Xinzhu, Nagai, Jun, Marti-Solano, Maria, Soto, Joselyn S., Coppola, Giovanni, Babu, M. Madan, Khakh, Baljit S.

“…Astrocytes tile the central nervous system and are widely implicated in brain diseases, but the molecular mechanisms by which astrocytes contribute to brain…”
Get full text

A Million Peptide Motifs for the Molecular Biologist by Tompa, Peter, Davey, Norman E., Gibson, Toby J., Babu, M. Madan

“…A molecular description of functional modules in the cell is the focus of many high-throughput studies in the postgenomic era. A large portion of biomolecular…”
Get full text

Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes by Cumberworth, Alexander, Lamour, Guillaume, Babu, M Madan, Gsponer, Jörg

“…Because of their pervasiveness in eukaryotic genomes and their unique properties, understanding the role that ID (intrinsically disordered) regions in proteins…”
Get more information

Discovery and Genetic Code Expansion of a Polyethylene Terephthalate (PET) Hydrolase from the Human Saliva Metagenome for the Degradation and Bio‐Functionalization of PET by Eiamthong, Bhumrapee, Meesawat, Piyachat, Wongsatit, Thanakrit, Jitdee, Jariya, Sangsri, Raweewan, Patchsung, Maturada, Aphicho, Kanokpol, Suraritdechachai, Surased, Huguenin‐Dezot, Nicolas, Tang, Shan, Suginta, Wipa, Paosawatyanyong, Boonchoat, Babu, M. Madan, Chin, Jason W., Pakotiprapha, Danaya, Bhanthumnavin, Worawan, Uttamapinant, Chayasith

“…We report a bioinformatic workflow and subsequent discovery of a new polyethylene terephthalate (PET) hydrolase, which we named MG8, from the human saliva…”
Get full text

An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease by Pardo, Mercedes, Lang, Benjamin, Yu, Lu, Prosser, Haydn, Bradley, Allan, Babu, M. Madan, Choudhary, Jyoti

“…The transcription factor Oct4 is key in embryonic stem cell identity and reprogramming. Insight into its partners should illuminate how the pluripotent state…”
Get full text

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation by Sente, Andrija, Peer, Raphael, Srivastava, Ashish, Baidya, Mithu, Lesk, Arthur M., Balaji, Santhanam, Shukla, Arun K., Babu, M. Madan, Flock, Tilman

“…Arrestins regulate the signaling of ligand-activated, phosphorylated G-protein-coupled receptors (GPCRs). Different patterns of receptor phosphorylation…”
Get full text

Biological impact of mutually exclusive exon switching by Lam, Su Datt, Babu, M Madan, Lees, Jonathan, Orengo, Christine A

“…Alternative splicing can expand the diversity of proteomes. Homologous mutually exclusive exons (MXEs) originate from the same ancestral exon and result in…”
Get full text

Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas by Kayikci, Melis, Venkatakrishnan, A. J., Scott-Brown, James, Ravarani, Charles N. J., Flock, Tilman, Babu, M. Madan

“…Visualizations of biomolecular structures empower us to gain insights into biological functions, generate testable hypotheses, and communicate biological…”
Get full text

Structural polymorphism in the N-terminal oligomerization domain of NPM1 by Mitrea, Diana M., Grace, Christy R., Buljan, Marija, Yun, Mi-Kyung, Pytel, Nicholas J., Satumba, John, Nourse, Amanda, Park, Cheon-Gil, Babu, M. Madan, White, Stephen W., Kriwacki, Richard W.

“…Nucleophosmin (NPM1) is a multifunctional phospho-protein with critical roles in ribosome biogenesis, tumor suppression, and nucleolar stress response. Here we…”
Get full text

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks by Buljan, Marija, Chalancon, Guilhem, Eustermann, Sebastian, Wagner, Gunter P., Fuxreiter, Monika, Bateman, Alex, Babu, M. Madan

“…Alternative inclusion of exons increases the functional diversity of proteins. Among alternatively spliced exons, tissue-specific exons play a critical role in…”
Get full text

Intrinsically disordered proteins: regulation and disease by Babu, M Madan, van der Lee, Robin, de Groot, Natalia Sanchez, Gsponer, Jörg

“…► Altered expression of intrinsically disordered proteins (IDPs) has been associated with disease. ► Most IDPs are tightly regulated and dosage-sensitive genes…”
Get full text

Genomic analysis of regulatory network dynamics reveals large topological changes by Luscombe, Nicholas M, Madan Babu, M, Teichmann, Sarah A, Gerstein, Mark, Yu, Haiyuan, Snyder, Michael

“…Network analysis has been applied widely, providing a unifying language to describe disparate systems ranging from social interactions to power grids. It has…”
Get full text