Search Results - "Babtie, Ann"

Topological sensitivity analysis for systems biology by Babtie, Ann C., Kirk, Paul, Stumpf, Michael P. H.

“…Significance Mathematical models are widely used to study natural systems. They allow us to test and generate hypotheses, and help us to understand the…”
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How to deal with parameters for whole-cell modelling by Babtie, Ann C., Stumpf, Michael P. H.

“…Dynamical systems describing whole cells are on the verge of becoming a reality. But as models of reality, they are only useful if we have realistic parameters…”
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Efficient Catalytic Promiscuity for Chemically Distinct Reactions by Babtie, Ann C, Bandyopadhyay, Subhajit, Olguin, Luis F, Hollfelder, Florian

“…High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition…”
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Simultaneous Determination of Gene Expression and Enzymatic Activity in Individual Bacterial Cells in Microdroplet Compartments by Shim, Jung-uk, Olguin, Luis F, Whyte, Graeme, Scott, Duncan, Babtie, Ann, Abell, Chris, Huck, Wilhelm T. S, Hollfelder, Florian

“…A microfluidic device capable of storing picoliter droplets containing single bacteria at constant volumes has been fabricated in PDMS. Once captured in…”
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efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily by van Loo, Bert, Jonas, Stefanie, Babtie, Ann C, Benjdia, Alhosna, Berteau, Olivier, Hyvönen, Marko, Hollfelder, Florian

“…We report a catalytically promiscuous enzyme able to efficiently promote the hydrolysis of six different substrate classes. Originally assigned as a…”
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Gene Regulatory Networks from Single Cell Data for Exploring Cell Fate Decisions by Chan, Thalia E, Stumpf, Michael P H, Babtie, Ann C

“…Single cell experimental techniques now allow us to quantify gene expression in up to thousands of individual cells. These data reveal the changes in…”
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MEANS: python package for Moment Expansion Approximation, iNference and Simulation by Fan, Sisi, Geissmann, Quentin, Lakatos, Eszter, Lukauskas, Saulius, Ale, Angelique, Babtie, Ann C, Kirk, Paul D W, Stumpf, Michael P H

“…Many biochemical systems require stochastic descriptions. Unfortunately these can only be solved for the simplest cases and their direct simulation can become…”
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Model of Host-Pathogen Interaction Dynamics Links In Vivo Optical Imaging and Immune Responses by Ale, Angelique, Crepin, Valerie F, Collins, James W, Constantinou, Nicholas, Habibzay, Maryam, Babtie, Ann C, Frankel, Gad, Stumpf, Michael P H

“…Tracking disease progression in vivo is essential for the development of treatments against bacterial infection. Optical imaging has become a central tool for…”
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Kinetic and computational evidence for an intermediate in the hydrolysis of sulfonate esters by Babtie, Ann C, Lima, Marcelo F, Kirby, Anthony J, Hollfelder, Florian

“…The hydrolytic reactions of sulfonate esters have previously been considered to occur by concerted mechanisms. We now report the observation of a break in a…”
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What makes an enzyme promiscuous? by Babtie, Ann, Tokuriki, Nobuhiko, Hollfelder, Florian

“…Kinetic analyses of promiscuous enzymes reveal rate accelerations, ( k cat /K M )/ k 2, of up to 10 18 for their secondary activities. Such large values…”
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Modelling heterogeneous intracellular networks at the cellular scale by Babtie, Ann C.

“…Cell function relies on the coordinated action of heterogeneous interconnected networks of biomolecules. Mathematical models help us explore the dynamics and…”
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Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs by Fidanza, Antonella, Stumpf, Patrick S., Ramachandran, Prakash, Tamagno, Sara, Babtie, Ann, Lopez-Yrigoyen, Martha, Taylor, A. Helen, Easterbrook, Jennifer, Henderson, Beth E.P., Axton, Richard, Henderson, Neil C., Medvinsky, Alexander, Ottersbach, Katrin, Romanò, Nicola, Forrester, Lesley M.

“…Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various anatomical sites during embryonic development. The in vitro…”
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3074 – SINGLE CELL TRANSCRIPTOMIC ANALYSIS COMBINED WITH MACHINE LEARNING IDENTIFIES HSC-LIKE CELLS DIFFERENTIATED IN VITRO FROM HUMAN IPSCS by Fidanza, Antonella, Stumpf, Patrick, Ramachandran, Prakash, Taylor, Helen, Tamagno, Sara, Babtie, Ann, Medvinsky, Alexander, Ottersbach, Katrin, Romano, Nicola, Forrester, Lesley

“…During embryonic development, haematopoietic stem and progenitor cells (HSPCs) develop in different waves at various anatomical sites. This process can be…”
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Stem Cell Differentiation as a Non-Markov Stochastic Process by Stumpf, Patrick S, Smith, Rosanna C G, Lenz, Michael, Schuppert, Andreas, Müller, Franz-Josef, Babtie, Ann, Chan, Thalia E, Stumpf, Michael P H, Please, Colin P, Howison, Sam D, Arai, Fumio, MacArthur, Ben D

“…Pluripotent stem cells can self-renew in culture and differentiate along all somatic lineages in vivo. While much is known about the molecular basis of…”
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Learning regulatory models for cell development from single cell transcriptomic data by Babtie, Ann C., Chan, Thalia E., Stumpf, Michael P.H.

“…Single cell transcriptomic data allow us to probe the transcriptional changes occurring during cell development in unprecedented detail. These complex datasets…”
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Metabolic engineering: enabling technology of a bio-based economy by Zhang, Jie, Babtie, Ann, Stephanopoulos, Gregory

“…► Motivation for transforming current oil-based economies into bio-based alternatives. ► Advances in biotechnology and metabolic engineering that are starting…”
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Effiziente katalytische Promiskuität für chemisch unterschiedliche Reaktionen by Babtie, Ann C., Bandyopadhyay, Subhajit, Olguin, Luis F., Hollfelder, Florian

“…Für die native und die promiske Reaktion der Arylsulfatase aus Pseudomonas aeruginosa (PAS) wurden gleichermaßen hohe katalytische Leistungen beobachtet, was…”
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Effiziente katalytische Promiskuität für chemisch unterschiedliche Reaktionen by Babtie, Ann C., Bandyopadhyay, Subhajit, Olguin, Luis F., Hollfelder, Florian

“…Abstract Für die native und die promiske Reaktion der Arylsulfatase aus Pseudomonas aeruginosa (PAS) wurden gleichermaßen hohe katalytische Leistungen…”
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