Search Results - "Babij, Carol"

STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells by BABIJ, Carol, YIHONG ZHANG, FAJARDO, Flordeliza, JACKSON, Angela, ZONDLO, James, YU SUN, ELLISON, Aaron R, PLEWA, Cherylene A, SAN MIGUEL, Tisha, ROBINSON, John, MCCARTER, John, SCHWANDNER, Ralf, KURZEJA, Robert J, JUDD, Ted, CARNAHAN, Josette, DUSSAULT, Isabelle, MUNZLI, Anke, SHEHABELDIN, Amro, FERNANDO, Manory, QUON, Kim, KASSNER, Paul D, RUEFLI-BRASSE, Astrid A, WATSON, Vivienne J

“…Despite the prevalence of KRAS mutations in human cancers, there remain no targeted therapies for treatment. The serine-threonine kinase STK33 has been…”
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Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth by Carnahan, Josette, Beltran, Pedro J, Babij, Carol, Le, Quynh, Rose, Mark J, Vonderfecht, Steven, Kim, Joseph L, Smith, Adrian L, Nagapudi, Karthik, Broome, Martin A, Fernando, Manory, Kha, Hue, Belmontes, Brian, Radinsky, Robert, Kendall, Richard, Burgess, Teresa L

“…Raf inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent activating mutations in B-Raf. Here, we show that…”
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A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death by Ham, Jonathan, Babij, Carol, Whitfield, Jonathan, Pfarr, Curt M, Lallemand, Dominique, Yaniv, Moshe, Rubin, Lee L

“…Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the…”
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Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons by Eilers, Andreas, Whitfield, Jonathan, Babij, Carol, Rubin, Lee L, Ham, Jonathan

“…When deprived of nerve growth factor (NGF), developing sympathetic neurons die by apoptosis. This death is associated with an increase in the level of c-Jun…”
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GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists by PARKER, E. M, BABIJ, C. K, LING XIA, MULLINS, D. E, SALISBURY, B. G, BALASUBRAMANIAM, A, BURRIER, R. E, GUZZI, M, HAMUD, F, MUKHOPADHYAY, G, RUDINSKI, M. S, TAO, Z, TICE, M

“…GR231118, BW1911U90, Bis(31/31')[[Cys31, Trp32, Nva34] neuropeptide Y(31-36)] (T-190) and [Trp-Arg-Nva-Arg-Tyr]2-NH2 (T-241) are peptide analogs of the…”
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Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression by Parker, Eric M, Monopoli, Angela, Ongini, Ennio, Lozza, Gianluca, Babij, Carol M

“…Immunophilin ligands such as rapamycin, FK506 and GPI-1046 have been reported to increase neurite outgrowth in vitro and to have neuroprotective activity in…”
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Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline by Smith, Adrian L, DeMorin, Frenel F, Paras, Nick A, Huang, Qi, Petkus, Jeffrey K, Doherty, Elizabeth M, Nixey, Thomas, Kim, Joseph L, Whittington, Douglas A, Epstein, Linda F, Lee, Matthew R, Rose, Mark J, Babij, Carol, Fernando, Manory, Hess, Kristen, Le, Quynh, Beltran, Pedro, Carnahan, Josette

“…The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is…”
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Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling by Liu, Longbin, Lee, Matthew R., Kim, Joseph L., Whittington, Douglas A., Bregman, Howard, Hua, Zihao, Lewis, Richard T., Martin, Matthew W., Nishimura, Nobuko, Potashman, Michele, Yang, Kevin, Yi, Shuyan, Vaida, Karina R., Epstein, Linda F., Babij, Carol, Fernando, Manory, Carnahan, Josette, Norman, Mark H.

“…[Display omitted] One of the challenges for targeting B-RafV600E with small molecule inhibitors had been achieving adequate selectivity over the wild-type…”
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STK33 Kinase Is Not Essential in KRAS-Dependent Cells–Response by Dussault, Isabelle, Carnahan, Josette, Babij, Carol, Zhang, Yihong, Watson, Vivienne J., Quon, Kim, Kassner, Paul D.

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Corrigendum to “Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling” [Bioorg. Med. Chem. 24 (2016) 2215–2234] by Liu, Longbin, Lee, Matthew R., Kim, Joseph L., Whittington, Douglas A., Bregman, Howard, Hua, Zihao, Lewis, Richard T., Martin, Matthew W., Nishimura, Nobuko, Potashman, Michele, Yang, Kevin, Yi, Shuyan, Vaida, Karina R., Epstein, Linda F., Babij, Carol, Fernando, Manory, Carnahan, Josette, Norman, Mark H.

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Abstract 253: Identification of STK33 kinase inhibitors for the validation of a synthetic lethal relationship between STK33 and mutant KRAS by Zhang, Yihong, Kurzeja, Robert, Munzli, Anke, Zondlo, James, Miguel, Tisha San, Robinson, John, McCarter, John, Schwandner, Ralf, Judd, Ted, Fernando, Manory, Babij, Carol, Carnahan, Josette, Dussault, Isabelle

“…Abstract The kinase activity of the serine/threonine kinase STK33 was recently shown to be required for the survival of cancer cell lines dependent on the KRAS…”
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Abstract 252: Evaluating the role of STK33 kinase in mutant KRAS cells by Babij, Carol, Shehabeldin, Amro, Fernando, Manory, Quon, Kim, Kassner, Paul, Ruefli-Brasse, Astrid, Watson, Vivienne, Fajardo, Flordeliza, Zhang, Yihong, Zondlo, James, Sun, Yu, Ellison, Aaron R., Plewa, Cherylene, Dussault, Isabelle, Carnahan, Josette

“…Abstract Tumors harboring KRAS mutations remain an elusive target for oncology therapeutics. A recent publication (Scholl et al 2009) described a high…”
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Abstract 21: Selective and potent inhibitors of the mutant B-Raf pathway paradoxically stimulate the MAPK pathway in wild-type B-Raf cells by Carnahan, Josette, Beltran, Pedro, Babij, Carol, Le, Quynh, Rose, Mark J., Vonderfecht, Steven, Kim, Joseph L., Smith, Adrian L., Broome, Martin A., Fernando, Manory, Kha, Hue, Belmontes, Brian, Radinsky, Robert, Kendall, Richard, Burgess, Teresa L.

“…Abstract B-Raf is a member of the Raf family of serine/threonine kinases, which also include A-Raf and C-Raf. While all 3 Raf kinases stimulate the MAPK…”
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Abstract 2681A: Structure-guided design of potent and selective inhibitors of B-Raf kinase displaying on-mechanism in vivo activity by Kim, Joseph L., Smith, Adrian L., Carnahan, Josette, Beltran, Pedro J., Whittington, Douglas A., Rose, Mark J., DeMorin, Frenel, Doherty, Elizabeth, Huang, Qi, Ncube, Mquele, Paras, Nick A., Petkus, Jeffrey K., Tasker, Andrew S., Lee, Matthew R., Babij, Carol, Fernando, Manory, Hess, Kristen, Le, Quynh, Epstein, Linda F., Yakowec, Peter S.

“…Abstract The Ras-Raf-MAPK signaling pathway plays a central role in diverse cellular processes including differentiation, proliferation and survival. This…”
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GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y 1 receptor antagonists and neuropeptide Y Y 4 receptor agonists by Parker, Eric M, Babij, Carol K, Balasubramaniam, Ambikaipakan, Burrier, Robert E, Guzzi, Mario, Hamud, Fozia, Gitali Mukhopadhyay, Rudinski, Mark S, Tao, Z, Tice, Melissa, Xia, Ling, Mullins, Deborra E, Salisbury, Brian G

“…GR231118, BW1911U90, Bis(31/31′){[Cys 31, Trp 32, Nva 34] neuropeptide Y(31–36)} (T-190) and [Trp–Arg–Nva–Arg–Tyr] 2-NH 2 (T-241) are peptide analogs of the…”
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