Search Results - "Babiak, John"

Metabolism and Disposition of Ataluren after Oral Administration to Mice, Rats, Dogs, and Humans by Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Goodwin, Elizabeth, Northcutt, Valerie, Babiak, John, Almstead, Neil, McIntosh, Joseph

“…Ataluren is a unique small molecule developed for the treatment of diseases caused by nonsense mutations, which result in premature termination of ribosomal…”
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Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform by Cao, Liangxian, Weetall, Marla, Bombard, Jenelle, Qi, Hongyan, Arasu, Tamil, Lennox, William, Hedrick, Jean, Sheedy, Josephine, Risher, Nicole, Brooks, Peter C, Trifillis, Panayiota, Trotta, Christopher, Moon, Young-Choon, Babiak, John, Almstead, Neil G, Colacino, Joseph M, Davis, Thomas W, Peltz, Stuart W

“…Current anti-VEGF (Vascular Endothelial Growth Factor A) therapies to treat various cancers indiscriminately block VEGF function in the patient resulting in…”
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In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren by Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Moon, Young‐Choon, Welch, Ellen M., Weetall, Marla, Colacino, Joseph M., Almstead, Neil, Babiak, John, Goodwin, Elizabeth

“…Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to…”
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Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation by Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young-Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spiegel, Robert, Peltz, Stuart W.

“…PTC299 is a novel small molecule that specifically blocks the production of protein from selected mRNAs that under certain conditions use noncanonical…”
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Design, Synthesis, and Biological Evaluation of Thio-Containing Compounds with Serum HDL-Cholesterol-Elevating Properties by Elokdah, Hassan, Sulkowski, Theodore S, Abou-Gharbia, Magid, Butera, John A, Chai, Sie-Yearl, McFarlane, Geraldine R, McKean, Mar-Lee, Babiak, John L, Adelman, Steven J, Quinet, Elaine M

“…A novel series of substituted sulfanyldihydroimidazolones (1) that modulates high-density lipoprotein cholesterol (HDL-C) has been reported to have…”
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Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs by Ma, Jiyuan, Ye, Qing, Northcutt, Valerie, Babiak, John, Kong, Ronald

“…Emvododstat is a potent inhibitor of dihydroorotate dehydrogenase and is now in clinical development for the treatment of acute myeloid leukaemia and COVID-19…”
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Absorption, distribution, metabolism and excretion of 14 C-Emvododstat following a single oral dose in rats and dogs by Ma, Jiyuan, Ye, Qing, Northcutt, Valerie, Babiak, John, Kong, Ronald

“…Emvododstat is a potent inhibitor of dihydroorotate dehydrogenase and is now in clinical development for the treatment of acute myeloid leukaemia and…”
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SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy by Naryshkin, Nikolai A., Weetall, Marla, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Feng, Zhihua, Ling, Karen K. Y., Karp, Gary M., Qi, Hongyan, Woll, Matthew G., Chen, Guangming, Zhang, Nanjing, Gabbeta, Vijayalakshmi, Vazirani, Priya, Bhattacharyya, Anuradha, Furia, Bansri, Risher, Nicole, Sheedy, Josephine, Kong, Ronald, Ma, Jiyuan, Turpoff, Anthony, Lee, Chang-Sun, Zhang, Xiaoyan, Moon, Young-Choon, Trifillis, Panayiota, Welch, Ellen M., Colacino, Joseph M., Babiak, John, Almstead, Neil G., Peltz, Stuart W., Eng, Loren A., Chen, Karen S., Mull, Jesse L., Lynes, Maureen S., Rubin, Lee L., Fontoura, Paulo, Santarelli, Luca, Haehnke, Daniel, McCarthy, Kathleen D., Schmucki, Roland, Ebeling, Martin, Sivaramakrishnan, Manaswini, Ko, Chien-Ping, Paushkin, Sergey V., Ratni, Hasane, Gerlach, Irene, Ghosh, Anirvan, Metzger, Friedrich

“…Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. A paralogous gene in humans,…”
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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties by Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Cintron, Katherine, Ma, Jiyuan, Kim, Min Jung, Furia, Bansri, Romfo, Charles, Graci, Jason D, Li, Wencheng, Du, Joshua, Sheedy, Josephine, Hedrick, Jean, Risher, Nicole, Yeh, Shirley, Qi, Hongyan, Arasu, Tamil, Hwang, Seongwoo, Lennox, William, Kong, Ronald, Petruska, Janet, Moon, Young-Choon, Babiak, John, Davis, Thomas W, Jacobson, Allan, Almstead, Neil G, Branstrom, Art, Colacino, Joseph M, Peltz, Stuart W

“…PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide…”
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PTC124 targets genetic disorders caused by nonsense mutations by Chen, Guangming, Jacobson, Allan, Spatrick, Phyllis, Peltz, Stuart W, Conn, M. Morgan, Friesen, Westley J, Almstead, Neil G, Hedrick, Jean, Campbell, Jeffrey A, Mollin, Anna, Kawana, Masataka, Wilde, Richard G, Yeh, Shirley, Sweeney, H. Lee, Trotta, Christopher R, Khan, Atiyya, Welch, Ellen M, Barton, Elisabeth R, Hirawat, Samit, Turpoff, Anthony A, Weetall, Marla, Ren, Hongyu, Risher, Nicole, Tomizawa, Yuki, Northcutt, Valerie J, Miller, Langdon L, He, Feng, Jones, Stephen, Colacino, Joseph M, Feng, Huisheng, Branstrom, Arthur A, Corson, Donald, Zhuo, Jin, Ju, William D, Patel, Meenal, Moon, Young-Choon, Hwang, Seongwoo, Paushkin, Sergey, Babiak, John, Trifillis, Panayiota, Karp, Gary, Takasugi, James

“…Nonsense mutations promote premature translational termination and cause anywhere from 5-70% of the individual cases of most inherited diseases. Studies on…”
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Identification of compounds that inhibit late steps of peptidoglycan synthesis in bacteria by DeCenzo, Maureen, Kuranda, Mike, Cohen, Seth, Babiak, John, Jiang, Zhi-Dong, Su, Dongyu, Hickey, Mark, Sancheti, Praveen, Bradford, Patricia A, Youngman, Phil, Projan, Steve, Rothstein, David M

“…A screening system is described that can detect and confirm inhibitors of the late steps of cell wall biosynthesis. The primary high through-put screen…”
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In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor by Ma, Jiyuan, Kaushik, Diksha, Yeh, Shirley, Northcutt, Valerie, Babiak, John, Risher, Nicole, Weetall, Marla, Moon, Young-Choon, Welch, Ellen M., Molony, Lachlan, O'Keefe, Kylie, Kong, Ronald

“…Emvododstat was identified as a potent inhibitor of dihydroorotate dehydrogenase and is now in clinical development for the treatment of acute myeloid…”
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Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy by Naryshkin, Nikolai A, Weetall, Marla, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Feng, Zhihua, Ling, Karen K Y, Karp, Gary M, Qi, Hongyan, Woll, Matthew G, Chen, Guangming, Zhang, Nanjing, Gabbeta, Vijayalakshmi, Vazirani, Priya, Bhattacharyya, Anuradha, Furia, Bansri, Risher, Nicole, Sheedy, Josephine, Kong, Ronald, Ma, Jiyuan, Turpoff, Anthony, Lee, Chang-Sun, Zhang, Xiaoyan, Moon, Young-Choon, Trifillis, Panayiota, Welch, Ellen M, Colacino, Joseph M, Babiak, John, Almstead, Neil G, Peltz, Stuart W, Eng, Loren A, Chen, Karen S, Mull, Jesse L, Lynes, Maureen S, Rubin, Lee L, Fontoura, Paulo, Santarelli, Luca, Haehnke, Daniel, McCarthy, Kathleen D, Schmucki, Roland, Ebeling, Martin, Sivaramakrishnan, Manaswini, Ko, Chien-Ping, Paushkin, Sergey V, Ratni, Hasane, Gerlach, Irene, Ghosh, Anirvan, Metzger, Friedrich

“…Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. A paralogous gene in humans,…”
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Placing and preserving priorities : projects, productivity, progress and people by BABIAK, J

“…High throughput screening (HTS) involves using automated equipment to test a large number of samples against a defined molecular target to identify a…”
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Gender differences in response to a hypercholesterolemic diet in hamsters: effects on plasma lipoprotein cholesterol concentrations and early aortic atherosclerosis by Wilson, Thomas A, Nicolosi, Robert J, Lawton, Carl W, Babiak, John

“…Gender is a strong predictor of coronary heart disease (CHD) susceptibility and reports indicate that males are more likely to develop CHD compared to…”
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Lecithin-cholesterol acyltransferase (LCAT) catalyzes transacylation of intact cholesteryl esters. Evidence for the partial reversal of the forward LCAT reaction by SORCI-THOMAS, M, BABIAK, J, RUDEL, L. L

“…Lecithin-cholesterol acyltransferase (LCAT) catalyzes the intravascular synthesis of lipoprotein cholesteryl esters by converting cholesterol and lecithin to…”
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The trials and tribulations of a robotic screening core by BABIAK, J, LUCOTCH, B, RUSSO, A, HEYDT, L, WILLIAMS, S, MCCAULLY, R

“…It is well recognized within the pharmaceutical industry that high throughput screening is a valuable and rapid tool to identify novel chemical compounds that…”
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Effects of Saturated and Polyunsaturated Dietary Fat on the Concentrations of HDL Subpopulations in African Green Monkeys by Babiak, John, Lindgren, Frank T, Rudel, Lawrence L

“…The effect of the type of dietary fat on the concentrations and compositions of high density llpoproteln (HDL) subpopulations was studied In groups of African…”
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Characterization of HDL and lipoproteins intermediate to LDL and HDL in the serum of pedigreed baboons fed an atherogenic diet by Babiak, J, Gong, E L, Nichols, A V, Forte, T M, Kuehl, T J, McGill, Jr, H C

“…A lipoprotein species with ultracentrifugal flotation rates (F0(1.20) 9-28) intermediate to high density lipoproteins (HDL, F0(1.20) 0-9) and low density…”
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Contraceptive Steroid Effects on Lipids and Lipoproteins in Cynomolgus Monkeys by Parks, John S, Pelkey, Susan J, Babiak, John, Clarkson, Thomas B

“…Seventy-three adult female cynomolgus monkeys fed an atherogenic diet were studied to determine the effect of two different combination contraceptive steroid…”
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