Search Results - "Babcock, Justin T"

Mammalian Target of Rapamycin Complex 1 (mTORC1) Enhances Bortezomib-induced Death in Tuberous Sclerosis Complex (TSC)-null Cells by a c-MYC-dependent Induction of the Unfolded Protein Response by Babcock, Justin T., Nguyen, Hoa B., He, Yujun, Hendricks, Jeremiah W., Wek, Ronald C., Quilliam, Lawrence A.

“…Many factors, including duration and intensity of the unfolded protein response (UPR), dictate whether cells will adapt to endoplasmic reticulum stress or…”
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Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin by Babcock, Justin T, Quilliam, Lawrence A

“…mTOR exists in two distinct complexes. mTOR complex 1 (mTORC1) is potently inhibited by the immunosupressive macrolide rapamycin; whereas, mTORC2 is…”
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Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress by Siroky, Brian J, Yin, Hong, Babcock, Justin T, Lu, Lu, Hellmann, Anna R, Dixon, Bradley P, Quilliam, Lawrence A, Bissler, John J

“…Tuberous sclerosis complex (TSC), an inherited tumor predisposition syndrome associated with mutations in TSC1 or TSC2, affects ∼1 in 6,000 individuals. Eighty…”
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M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells by Castro, Ariel F., Campos, Tania, Babcock, Justin T., Armijo, Marisol E., Martínez-Conde, Alfonso, Pincheira, Roxana, Quilliam, Lawrence A.

“…Constitutive activation of M‐Ras has previously been reported to cause morphologic and growth transformation of murine cells, suggesting that M‐Ras plays a…”
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Abstract LB-247: mTORC1 enhances bortezomib-induced death in TSC-null cells by a c-MYC-dependent induction of the unfolded protein response by Babcock, Justin T., Nguen, Hoa B., He, Yujun, Wek, Ronald C., Quilliam, Lawrence A.

“…Abstract The ability of the proteasome inhibitor bortezomib to induce apoptosis of cancer cells is influenced by a variety of signaling pathways. We have found…”
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Abstract LB-29: LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap by Nguyen, Hoa B., Babcock, Justin T., Wells, Clark D., Quilliam, Lawrence A.

“…Abstract The liver kinase B1 (LKB1) tumor suppressor inhibits cell growth through its regulation of cellular metabolism and apical-basal polarity. The best…”
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LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap by Nguyen, H B, Babcock, J T, Wells, C D, Quilliam, L A

“…The liver kinase B1 (LKB1) tumor suppressor inhibits cell growth through its regulation of cellular metabolism and apical–basal polarity. The best understood…”
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