Search Results - "Babbitt, Courtney"

The predictive nature of transcript expression levels on protein expression in adult human brain by Bauernfeind, Amy L, Babbitt, Courtney C

“…Next generation sequencing methods are the gold standard for evaluating expression of the transcriptome. When determining the biological implications of such…”
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The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network by Garfield, David A, Runcie, Daniel E, Babbitt, Courtney C, Haygood, Ralph, Nielsen, William J, Wray, Gregory A

“…Regulatory interactions buffer development against genetic and environmental perturbations, but adaptation requires phenotypes to change. We investigated the…”
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Differentially Active and Conserved Neural Enhancers Define Two Forms of Adaptive Noncoding Evolution in Humans by Pizzollo, Jason, Zintel, Trisha M, Babbitt, Courtney C

“…Abstract The human and chimpanzee genomes are strikingly similar, but our neural phenotypes are very different. Many of these differences are likely driven by…”
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Metabolic changes in human brain evolution by Bauernfeind, Amy L., Babbitt, Courtney C.

“…Because the human brain is considerably larger than those of other primates, it is not surprising that its energy requirements would far exceed that of any of…”
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Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears by Liu, Shiping, Lorenzen, Eline D., Fumagalli, Matteo, Li, Bo, Harris, Kelley, Xiong, Zijun, Zhou, Long, Korneliussen, Thorfinn Sand, Somel, Mehmet, Babbitt, Courtney, Wray, Greg, Li, Jianwen, He, Weiming, Wang, Zhuo, Fu, Wenjing, Xiang, Xueyan, Morgan, Claire C., Doherty, Aoife, O’Connell, Mary J., McInerney, James O., Born, Erik W., Dalén, Love, Dietz, Rune, Orlando, Ludovic, Sonne, Christian, Zhang, Guojie, Nielsen, Rasmus, Willerslev, Eske, Wang, Jun

“…Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyperlipid…”
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Convergent adaptation of human lactase persistence in Africa and Europe by Tishkoff, Sarah A, Reed, Floyd A, Ranciaro, Alessia, Voight, Benjamin F, Babbitt, Courtney C, Silverman, Jesse S, Powell, Kweli, Mortensen, Holly M, Hirbo, Jibril B, Osman, Maha, Ibrahim, Muntaser, Omar, Sabah A, Lema, Godfrey, Nyambo, Thomas B, Ghori, Jilur, Bumpstead, Suzannah, Pritchard, Jonathan K, Wray, Gregory A, Deloukas, Panos

“…A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the…”
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Astrocytes drive divergent metabolic gene expression in humans and chimpanzees by Zintel, Trisha M, Pizzollo, Jason, Claypool, Christopher G, Babbitt, Courtney C

“…The human brain utilizes ∼ 20% of all of the body's metabolic resources, while chimpanzee brains use less than 10%. Although previous work shows significant…”
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Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection by Shibata, Yoichiro, Sheffield, Nathan C, Fedrigo, Olivier, Babbitt, Courtney C, Wortham, Matthew, Tewari, Alok K, London, Darin, Song, Lingyun, Lee, Bum-Kyu, Iyer, Vishwanath R, Parker, Stephen C J, Margulies, Elliott H, Wray, Gregory A, Furey, Terrence S, Crawford, Gregory E

“…Understanding the molecular basis for phenotypic differences between humans and other primates remains an outstanding challenge. Mutations in non-coding…”
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Contrasts between adaptive coding and noncoding changes during human evolution by Haygood, Ralph, Babbitt, Courtney C, Fedrigo, Olivier, Wray, Gregory A

“…Changes in non-protein-coding regulatory DNA sequences have been proposed to play distinctive roles in adaptive evolution. We analyzed correlations between…”
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Recent advances in functional assays of transcriptional enhancers by Babbitt, Courtney C., Markstein, Michele, Gray, Jesse M.

“…In this special edition of Genomics, we present reviews of the current state of the field in identifying and functionally understanding transcriptional…”
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Tempo and mode of gene expression evolution in the brain across primates by Rickelton, Katherine, Zintel, Trisha M, Pizzollo, Jason, Miller, Emily, Ely, John J, Raghanti, Mary Ann, Hopkins, William D, Hof, Patrick R, Sherwood, Chet C, Bauernfeind, Amy L, Babbitt, Courtney C

“…Primate evolution has led to a remarkable diversity of behavioral specializations and pronounced brain size variation among species (Barton, 2012; DeCasien and…”
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Gene expression and adaptive noncoding changes during human evolution by Babbitt, Courtney C, Haygood, Ralph, Nielsen, William J, Wray, Gregory A

“…Despite evidence for adaptive changes in both gene expression and non-protein-coding, putatively regulatory regions of the genome during human evolution, the…”
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Genetics of gene expression responses to temperature stress in a sea urchin gene network by RUNCIE, DANIEL E., GARFIELD, DAVID A., BABBITT, COURTNEY C., WYGODA, JENNIFER A., MUKHERJEE, SAYAN, WRAY, GREGORY A.

“…Stress responses play an important role in shaping species distributions and robustness to climate change. We investigated how stress responses alter the…”
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The appropriation of glucose through primate neurodevelopment by Bauernfeind, Amy L., Babbitt, Courtney C.

“…The human brain is considerably larger and more energetically costly than that of other primate species. As such, discovering how human ancestors were able to…”
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Genetic Mutations Associated with Hormone-Positive Breast Cancer in a Small Cohort of Ethiopian Women by Schwartz, Alyssa D., Adusei, Afua, Tsegaye, Solomon, Moskaluk, Christopher A., Schneider, Sallie S., Platt, Manu O., Seifu, Daniel, Peyton, Shelly R., Babbitt, Courtney C.

“…In Ethiopia, a breast cancer diagnosis is associated with a prognosis significantly worse than that of Europe and the US. Further, patients presenting with…”
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Genomic signatures of diet-related shifts during human origins by Babbitt, Courtney C., Warner, Lisa R., Fedrigo, Olivier, Wall, Christine E., Wray, Gregory A.

“…There are numerous anthropological analyses concerning the importance of diet during human evolution. Diet is thought to have had a profound influence on the…”
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Immune System Promiscuity in Human and Nonhuman Primate Evolution by Brinkworth, Jessica F., Babbitt, Courtney C.

“…Many genes that respond to infection have functions outside of immunity and have been found to be under natural selection. Pathogens may therefore incidentally…”
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High spatial resolution proteomic comparison of the brain in humans and chimpanzees by Bauernfeind, Amy L., Reyzer, Michelle L., Caprioli, Richard M., Ely, John J., Babbitt, Courtney C., Wray, Gregory A., Hof, Patrick R., Sherwood, Chet C.

“…ABSTRACT We performed high‐throughput mass spectrometry at high spatial resolution from individual regions (anterior cingulate and primary motor,…”
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Comparative Serum Challenges Show Divergent Patterns of Gene Expression and Open Chromatin in Human and Chimpanzee by Pizzollo, Jason, Nielsen, William J, Shibata, Yoichiro, Safi, Alexias, Crawford, Gregory E, Wray, Gregory A, Babbitt, Courtney C

“…Humans experience higher rates of age-associated diseases than our closest living evolutionary relatives, chimpanzees. Environmental factors can explain many…”
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Genetic comparisons yield insight into the evolution of enamel thickness during human evolution by Horvath, Julie E., Ramachandran, Gowri L., Fedrigo, Olivier, Nielsen, William J., Babbitt, Courtney C., St. Clair, Elizabeth M., Pfefferle, Lisa W., Jernvall, Jukka, Wray, Gregory A., Wall, Christine E.

“…Enamel thickness varies substantially among extant hominoids and is a key trait with significance for interpreting dietary adaptation, life history trajectory,…”
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