Search Results - "Babayan, A."

Predicting reservoir hosts and arthropod vectors from evolutionary signatures in RNA virus genomes by Babayan, Simon A, Orton, Richard J, Streicker, Daniel G

“…Identifying the animal origins of RNA viruses requires years of field and laboratory studies that stall responses to emerging infectious diseases. Using large…”
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Identifying and prioritizing potential human-infecting viruses from their genome sequences by Mollentze, Nardus, Babayan, Simon A, Streicker, Daniel G

“…Determining which animal viruses may be capable of infecting humans is currently intractable at the time of their discovery, precluding prioritization of…”
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Wild immunology by PEDERSEN, AMY B., BABAYAN, SIMON A.

“…In wild populations, individuals are regularly exposed to a wide range of pathogens. In this context, organisms must elicit and regulate effective immune…”
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Role of the Escherichia coli FocA and FocB formate channels in controlling proton/potassium fluxes and hydrogen production during osmotic stress in energy-limited, stationary phase fermenting cells by Babayan, A., Vassilian, A., Poladyan, A., Trchounian, K.

“…Escherichia coli FocA and FocB formate channels export formate or import it for further disproportionation by the formate hydrogenlyase (FHL) complex to H2 and…”
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Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity by Buck, Amy H., Coakley, Gillian, Simbari, Fabio, McSorley, Henry J., Quintana, Juan F., Le Bihan, Thierry, Kumar, Sujai, Abreu-Goodger, Cei, Lear, Marissa, Harcus, Yvonne, Ceroni, Alessandro, Babayan, Simon A., Blaxter, Mark, Ivens, Alasdair, Maizels, Rick M.

“…In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus , which infects…”
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Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling by Chen, Y, Kramár, E A, Chen, L Y, Babayan, A H, Andres, A L, Gall, C M, Lynch, G, Baram, T Z

“…Stress is ubiquitous in modern life and exerts profound effects on cognitive and emotional functions. Thus, whereas acute stress enhances memory, longer…”
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Assessing the feasibility of applying machine learning to diagnosing non-effusive feline infectious peritonitis by Dunbar, Dawn, Babayan, Simon A., Krumrie, Sarah, Haining, Hayley, Hosie, Margaret J., Weir, William

“…Feline infectious peritonitis (FIP) is a severe feline coronavirus-associated syndrome in cats, which is invariably fatal without anti-viral treatment. In the…”
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Rapid age-grading and species identification of natural mosquitoes for malaria surveillance by Siria, Doreen J., Sanou, Roger, Mitton, Joshua, Mwanga, Emmanuel P., Niang, Abdoulaye, Sare, Issiaka, Johnson, Paul C. D., Foster, Geraldine M., Belem, Adrien M. G., Wynne, Klaas, Murray-Smith, Roderick, Ferguson, Heather M., González-Jiménez, Mario, Babayan, Simon A., Diabaté, Abdoulaye, Okumu, Fredros O., Baldini, Francesco

“…The malaria parasite, which is transmitted by several Anopheles mosquito species, requires more time to reach its human-transmissible stage than the average…”
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Using transfer learning and dimensionality reduction techniques to improve generalisability of machine-learning predictions of mosquito ages from mid-infrared spectra by Mwanga, Emmanuel P, Siria, Doreen J, Mitton, Joshua, Mshani, Issa H, González-Jiménez, Mario, Selvaraj, Prashanth, Wynne, Klaas, Baldini, Francesco, Okumu, Fredros O, Babayan, Simon A

“…Old mosquitoes are more likely to transmit malaria than young ones. Therefore, accurate prediction of mosquito population age can drastically improve the…”
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The age-dependent relationship between resting heart rate variability and functional brain connectivity by Kumral, D., Schaare, H.L., Beyer, F., Reinelt, J., Uhlig, M., Liem, F., Lampe, L., Babayan, A., Reiter, A., Erbey, M., Roebbig, J., Loeffler, M., Schroeter, M.L., Husser, D., Witte, A.V., Villringer, A., Gaebler, M.

“…Resting heart rate variability (HRV), an index of parasympathetic cardioregulation and an individual trait marker related to mental and physical health,…”
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On an Efficient Solution of the Dirichlet Problem for Properly Elliptic Equation in the Elliptic Domain by Babayan, A. H., Veziryan, R. M.

“…The fourth-order properly elliptic equation with multiple root is considered in the elliptic domain. The conditions, necessary and sufficient for the unique…”
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On a Dirichlet problem for one improperly elliptic equation by Babayan, A. H.

“…The Dirichlet problem for sixth-order improperly elliptic equation is considered. The functional class of boundary functions, where this problem is normally…”
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Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection by Babayan, Simon A., Sinclair, Amy, Duprez, Jessica S., Selman, Colin

“…Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over…”
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The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing by Crowe, Jenny, Lumb, Felicity E, Doonan, James, Broussard, Margaux, Tarafdar, Anuradha, Pineda, Miguel A, Landabaso, Carmen, Mulvey, Lorna, Hoskisson, Paul A, Babayan, Simon A, Selman, Colin, Harnett, William, Harnett, Margaret M

“…Improvements in hygiene and health management have driven significant increases in human lifespan over the last 50 years. Frustratingly however, this extension…”
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Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels by Kilarski, Witold W., Martin, Coralie, Pisano, Marco, Bain, Odile, Babayan, Simon A, Swartz, Melody A.

“…Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their…”
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Rapid Effects of Oestrogen on Synaptic Plasticity: Interactions with Actin and Its Signalling Proteins by Babayan, A. H., Kramár, E. A.

“…Oestrogen rapidly enhances fast excitatory postsynaptic potentials, facilitates long‐term potentiation (LTP) and increases spine numbers. Each effect likely…”
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Reagent-free detection of Plasmodium falciparum malaria infections in field-collected mosquitoes using mid-infrared spectroscopy and machine learning by Mwanga, Emmanuel P., Kweyamba, Prisca A., Siria, Doreen J., Mshani, Issa H., Mchola, Idrisa S., Makala, Faraja E., Seleman, Godian, Abbasi, Said, Mwinyi, Sophia H., González-Jiménez, Mario, Waynne, Klaas, Baldini, Francesco, Babayan, Simon A., Okumu, Fredros O.

“…Field-derived metrics are critical for effective control of malaria, particularly in sub-Saharan Africa where the disease kills over half a million people…”
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Key considerations, target product profiles, and research gaps in the application of infrared spectroscopy and artificial intelligence for malaria surveillance and diagnosis by Mshani, Issa H, Siria, Doreen J, Mwanga, Emmanuel P, Sow, Bazoumana Bd, Sanou, Roger, Opiyo, Mercy, Sikulu-Lord, Maggy T, Ferguson, Heather M, Diabate, Abdoulaye, Wynne, Klaas, González-Jiménez, Mario, Baldini, Francesco, Babayan, Simon A, Okumu, Fredros

“…Studies on the applications of infrared (IR) spectroscopy and machine learning (ML) in public health have increased greatly in recent years. These technologies…”
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Using mid-infrared spectroscopy and supervised machine-learning to identify vertebrate blood meals in the malaria vector, Anopheles arabiensis by Mwanga, Emmanuel P, Mapua, Salum A, Siria, Doreen J, Ngowo, Halfan S, Nangacha, Francis, Mgando, Joseph, Baldini, Francesco, González Jiménez, Mario, Ferguson, Heather M, Wynne, Klaas, Selvaraj, Prashanth, Babayan, Simon A, Okumu, Fredros O

“…The propensity of different Anopheles mosquitoes to bite humans instead of other vertebrates influences their capacity to transmit pathogens to humans…”
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Screening of malaria infections in human blood samples with varying parasite densities and anaemic conditions using AI-Powered mid-infrared spectroscopy by Mshani, Issa H, Jackson, Frank M, Mwanga, Rehema Y, Kweyamba, Prisca A, Mwanga, Emmanuel P, Tambwe, Mgeni M, Hofer, Lorenz M, Siria, Doreen J, González-Jiménez, Mario, Wynne, Klaas, Moore, Sarah J, Okumu, Fredros, Babayan, Simon A, Baldini, Francesco

“…Effective testing for malaria, including the detection of infections at very low densities, is vital for the successful elimination of the disease…”
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