Search Results - "Baba, Masaya"
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Editorial Comment to Annexin A1 expression is correlated with malignant potential of renal cell carcinoma
Published in International journal of urology (01-02-2019)Get full text
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MiT/TFE Family Renal Cell Carcinoma
Published in Genes (05-01-2023)“…The microphthalmia-associated transcription factor/transcription factor E (MiT/TFE) family of transcription factors are evolutionarily conserved, basic…”
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MicroRNA‐204‐5p: A novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma
Published in Cancer science (01-06-2019)“…Xp11.2 translocation renal cell carcinoma (Xp11 tRCC) is a rare sporadic pediatric kidney cancer caused by constitutively active TFE3 fusion proteins. Tumors…”
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Blood and lymphatic systems are segregated by the FLCN tumor suppressor
Published in Nature communications (09-12-2020)“…Blood and lymphatic vessels structurally bear a strong resemblance but never share a lumen, thus maintaining their distinct functions. Although lymphatic…”
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Rapid Point-of-Care Test for Hepatitis B Core-Related Antigen to Diagnose High Viral Load in Resource-Limited Settings
Published in Clinical gastroenterology and hepatology (01-07-2023)Get full text
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Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide–chlorambucil conjugate
Published in Cancer science (01-07-2022)“…Renal cell carcinoma with Xp11.2 translocation involving the TFE3 gene (TFE3‐RCC) is a recently identified subset of RCC with unique morphology and clinical…”
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Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome
Published in International journal of urology (01-03-2016)“…Birt–Hogg–Dubé syndrome is an autosomal dominantly inherited disease that predisposes patients to develop fibrofolliculoma, lung cysts and bilateral multifocal…”
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Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity
Published in Genes & development (01-12-2019)“…Angiopoietin-like protein 2 (ANGPTL2) is a secreted glycoprotein homologous to angiopoietins. Previous studies suggest that tumor cell-derived ANGPTL2 has…”
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Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization
Published in PloS one (29-12-2010)“…Germline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé…”
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TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease
Published in Molecular cancer research (01-08-2019)“…Renal cell carcinoma (RCC) associated with Xp11.2 translocation (TFE3-RCC) has been recently defined as a distinct subset of RCC classified by characteristic…”
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Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn
Published in Proceedings of the National Academy of Sciences - PNAS (31-03-2015)“…Significance The role of FLCN as a tumor suppressor in kidney cancer has been well documented, whereas the functional roles of folliculin (FLCN)-interacting…”
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ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion
Published in Molecular oncology (01-12-2023)“…Loss or downregulation of major histocompatibility complex class I (MHC‐I) contributes to tumor immune evasion. We previously demonstrated that…”
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TFEB‐translocated and ‐amplified renal cell carcinoma with VEGFA co‐amplification: A case of long‐term control by multimodal therapy including a vascular endothelial growth factor‐receptor inhibitor
Published in IJU case reports (01-05-2023)“…Introduction Renal cell carcinoma with TFEB amplification is rare and reportedly aggressive. We herein report a case of renal cell carcinoma with TFEB…”
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Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3
Published in The Journal of immunology (1950) (01-12-2019)“…Folliculin interacting protein 1 (Fnip1) is a cytoplasmic protein originally discovered through its interaction with the master metabolic sensor 5'…”
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Homozygous Loss of BHD Causes Early Embryonic Lethality and Kidney Tumor Development with Activation of mTORC1 and mTORC2
Published in Proceedings of the National Academy of Sciences - PNAS (03-11-2009)“…Germline mutations in the BHD/FLCN tumor suppressor gene pre-dispose patients to develop renal tumors in the hamartoma syndrome, Birt-Hogg-Dubé (BHD). BHD…”
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Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN
Published in JNCI : Journal of the National Cancer Institute (21-11-2012)“…Birt-Hogg-Dubé (BHD) syndrome is a hereditary hamartoma syndrome that predisposes patients to develop hair follicle tumors, lung cysts, and kidney cancer…”
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A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity
Published in Cell reports (Cambridge) (11-02-2020)“…The tumor suppressor folliculin (FLCN) suppresses nuclear translocation of TFE3, a master transcription factor for lysosomal biogenesis, via regulation of…”
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Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation
Published in Journal of bone and mineral research (01-10-2018)“…ABSTRACT Osteoclast differentiation is a dynamic differentiation process, which is accompanied by dramatic changes in metabolic status as well as in gene…”
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Folliculin Encoded by the BHD Gene Interacts with a Binding Protein, FNIP1, and AMPK, and Is Involved in AMPK and mTOR Signaling
Published in Proceedings of the National Academy of Sciences - PNAS (17-10-2006)“…Birt-Hogg-Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line…”
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Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages
Published in Cell death discovery (23-07-2020)“…Recent studies have revealed that tissue macrophages are derived from yolk sac precursors or fetal liver monocytes, in addition to bone marrow monocytes. The…”
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