Crimean-Congo Hemorrhagic Fever Virus, Mongolia, 2013-2014

During 2013-2014, we collected 1,926 serum samples from humans and 4,583 ticks (Hyalomma asiaticum or Dermacentor nuttalli) in select regions of Mongolia to determine the risk for Crimean-Congo hemorrhagic fever virus (CCHFV) infection among humans in this country. Testing of human serum samples by...

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Published in:	Emerging infectious diseases Vol. 24; no. 12; pp. 2202 - 2209
Main Authors:	Voorhees, Matthew A, Padilla, Susana L, Jamsransuren, Dulamjav, Koehler, Jeffrey W, Delp, Korey L, Adiyadorj, Dolgorkhand, Baasandagwa, Uyanga, Jigjav, Battsetseg, Olschner, Scott P, Minogue, Timothy D, Schoepp, Randal J
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-12-2018 Centers for Disease Control and Prevention
Subjects:	Animals Antibodies, Neutralizing - immunology Antibodies, Viral - immunology CCHF CCHFV Computational Biology Crimean hemorrhagic fever Crimean-Congo hemorrhagic fever Crimean-Congo Hemorrhagic Fever Virus, Mongolia, 2013–2014 Diagnosis Geography, Medical Hemorrhagic Fever Virus, Crimean-Congo - classification Hemorrhagic Fever Virus, Crimean-Congo - genetics Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification Hemorrhagic Fever, Crimean - epidemiology Hemorrhagic Fever, Crimean - history Hemorrhagic Fever, Crimean - transmission Hemorrhagic Fever, Crimean - virology History, 21st Century Humans Immunoglobulin G - immunology Mongolia Mongolia - epidemiology Neutralization Tests Phylogenetic trees Phylogeny Risk factors RNA, Viral Sequence Analysis, DNA Serologic Tests serosurvey ticks Ticks - virology Mongolia CCHF viruses ticks zoonoses Dermacentor nuttalli Crimean-Congo hemorrhagic fever tickborne disease Mongolia serosurvey vector-borne infections CCHFV Hyalomma asiaticum S segment M segment
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Summary:	During 2013-2014, we collected 1,926 serum samples from humans and 4,583 ticks (Hyalomma asiaticum or Dermacentor nuttalli) in select regions of Mongolia to determine the risk for Crimean-Congo hemorrhagic fever virus (CCHFV) infection among humans in this country. Testing of human serum samples by ELISA demonstrated an overall CCHFV antibody prevalence of 1.4%; Bayankhongor Province had the highest prevalence, 2.63%. We pooled and analyzed tick specimens by real-time reverse transcription PCR; 1 CCHFV-positive H. asiaticum tick pool from Ömnögovi was identified. In phylogenetic analyses, the virus's partial small segment clustered with CCHFV isolates from Central Asia, and the complete medium segment grouped with CCHFV isolates from Africa, Asia, and the Middle East. This study confirms CCHFV endemicity in Mongolia and provides information on risk for CCHFV infection. Further research is needed to better define the risk for CCHFV disease to improve risk mitigation, diagnostics, and surveillance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2412.180175