Search Results - "Baas, Jan"

Bee sensitivity derived from acute contact tests biased by standardised protocols? by Baas, Jan, Knautz, Timm, Barme, Annika, Sekine, Tatsuya, Jaklofsky, Marcel, Belgers, Dick, Jansen, Nina, Boerwinkel, Marie-Claire, Roessink, Ivo

“…In an acute contact test with bees the compound of interest is dissolved in a carrier solvent (frequently acetone) and then a droplet of the solution is placed…”
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Comparing bee species responses to chemical mixtures: Common response patterns? by Robinson, Alex, Hesketh, Helen, Lahive, Elma, Horton, Alice A, Svendsen, Claus, Rortais, Agnes, Dorne, Jean Lou, Baas, Jan, Heard, Matthew S, Spurgeon, David J

“…Pollinators in agricultural landscapes can be exposed to mixtures of pesticides and environmental pollutants. Existing mixture toxicity modelling approaches,…”
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Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases by van der Meer, Jan-Ytzen, Poddar, Harshwardhan, Baas, Bert-Jan, Miao, Yufeng, Rahimi, Mehran, Kunzendorf, Andreas, van Merkerk, Ronald, Tepper, Pieter G., Geertsema, Edzard M., Thunnissen, Andy-Mark W. H., Quax, Wim J., Poelarends, Gerrit J.

“…The Michael-type addition reaction is widely used in organic synthesis for carbon–carbon bond formation. However, biocatalytic methodologies for this type of…”
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Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase by Zandvoort, Ellen, Geertsema, Edzard M., Baas, Bert-Jan, Quax, Wim J., Poelarends, Gerrit J.

“…Non‐natural beauty: The enzyme 4‐oxalocrotonate tautomerase (4‐OT) promiscuously (i.e., with non‐natural activity) catalyzes the Michael‐type addition of…”
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Self-Sufficient Baeyer-Villiger Monooxygenases: Effective Coenzyme Regeneration for Biooxygenation by Fusion Engineering by Torres Pazmiño, Daniel E, Snajdrova, Radka, Baas, Bert-Jan, Ghobrial, Michael, Mihovilovic, Marko D, Fraaije, Marco W

“…Two‐in‐one biocatalysts were engineered by the covalent fusion of NADPH‐dependent Baeyer–Villiger monooxygenases to a phosphite dehydrogenase for coenzyme…”
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Recent Advances in the Study of Enzyme Promiscuity in the Tautomerase Superfamily by Baas, Bert-Jan, Zandvoort, Ellen, Geertsema, Edzard M., Poelarends, Gerrit J.

“…Catalytic promiscuity and evolution: Many enzymes exhibit catalytic promiscuity—the ability to catalyze reactions other than their biologically relevant one…”
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Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy by Ourailidou, Maria Eleni, van der Meer, Jan-Ytzen, Baas, Bert-Jan, Jeronimus-Stratingh, Margot, Gottumukkala, Aditya L., Poelarends, Gerrit J., Minnaard, Adriaan J., Dekker, Frank J.

“…An increasing number of chemical reactions are being employed for bio‐orthogonal ligation of detection labels to protein‐bound functional groups. Several of…”
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Kinetic Mechanism of Phenylacetone Monooxygenase from Thermobifida fusca by Torres Pazmiño, Daniel E, Baas, Bert-Jan, Janssen, Dick B, Fraaije, Marco W

“…Phenylacetone monooxygenase (PAMO) from Thermobifida fusca is a FAD-containing Baeyer-Villiger monooxygenase (BVMO). To elucidate the mechanism of conversion…”
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Systematic Screening for Catalytic Promiscuity in 4-Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity by Zandvoort, Ellen, Baas, Bert-Jan, Quax, Wim J., Poelarends, Gerrit J.

“…The enzyme 4‐oxalocrotonate tautomerase (4‐OT) is part of a catabolic pathway for aromatic hydrocarbons in Pseudomonas putida mt‐2, where it catalyzes the…”
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biology-based approach for mixture toxicity of multiple endpoints over the life cycle by Jager, Tjalling, Vandenbrouck, Tine, Baas, Jan, De Coen, Wim M, Kooijman, Sebastiaan A. L. M

“…Typical approaches for analyzing mixture ecotoxicity data only provide a description of the data; they cannot explain observed interactions, nor explain why…”
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Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4-Oxalocrotonate Tautomerase More Effectively than Distant Mutations by Rahimi, Mehran, van der Meer, Jan-Ytzen, Geertsema, Edzard M., Poddar, Harshwardhan, Baas, Bert-Jan, Poelarends, Gerrit J.

“…The enzyme 4‐oxalocrotonate tautomerase (4‐OT), which catalyzes enol–keto tautomerization as part of a degradative pathway for aromatic hydrocarbons,…”
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An Unexpected Promiscuous Activity of 4-Oxalocrotonate Tautomerase: The cis-trans Isomerisation of Nitrostyrene by Zandvoort, Ellen, Geertsema, Edzard M., Baas, Bert-Jan, Quax, Wim J., Poelarends, Gerrit J.

“…Serendipitous switch: While exploring cis‐nitrostyrene as a potential electrophile in Michael‐type addition reactions catalysed by the enzyme 4‐oxalocrotonate…”
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Dehalogenation of an Anthropogenic Compound by an Engineered Variant of the Mouse Cytokine Macrophage Migration Inhibitory Factor by Wasiel, Anna A., Baas, Bert-Jan, Zandvoort, Ellen, Quax, Wim J., Poelarends, Gerrit J.

“…An unconventional dehalogenase: An engineered variant (I64V/V106L) of the mouse cytokine macrophage migration inhibitory factor (MIF) promiscuously catalyzes…”
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Introduction of Asymmetry in the Fused 4‑Oxalocrotonate Tautomerases by Erwin, Kaci, Moreno, R. Yvette, Baas, Bert-Jan, Zhang, Y. Jessie, Whitman, Christian P.

“…Members of the 4-oxalocrotonate tautomerase (4-OT) subgroup in the tautomerase superfamily (TSF) are constructed from a single β–α–β unit and form homo- or…”
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Demethionylation of Pro-1 variants of 4-oxalocrotonate tautomerase in Escherichia coli by co-expression with an engineered methionine aminopeptidase by Baas, Bert-Jan, Zandvoort, Ellen, Wasiel, Anna A., Poelarends, Gerrit J.

“…An amino-terminal proline analogue: The enzyme 4-oxalocrotonate tautomerase (4-OT) is characterized by a catalytic N-terminal proline. The substitution of…”
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Kinetic, Inhibition, and Structural Characterization of a Malonate Semialdehyde Decarboxylase-like Protein from Calothrix sp. PCC 6303: A Gateway to the non-Pro1 Tautomerase Superfamily Members by Lancaster, Emily B., Yang, Wanjie, Johnson, William H., Baas, Bert-Jan, Zhang, Yan Jessie, Whitman, Christian P.

“…The amino-terminal proline (Pro1) has long been thought to be a mechanistic imperative for tautomerase superfamily (TSF) enzymes, functioning as a general base…”
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A global view of structure–function relationships in the tautomerase superfamily by Davidson, Rebecca, Baas, Bert-Jan, Akiva, Eyal, Holliday, Gemma L., Polacco, Benjamin J., LeVieux, Jake A., Pullara, Collin R., Zhang, Yan Jessie, Whitman, Christian P., Babbitt, Patricia C.

“…The tautomerase superfamily (TSF) consists of more than 11,000 nonredundant sequences present throughout the biosphere. Characterized members have attracted…”
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Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications by Baas, Bert-Jan, Medellin, Brenda P, LeVieux, Jake A, Erwin, Kaci, Lancaster, Emily B, Johnson, William H, Kaoud, Tamer S, Moreno, R. Yvette, de Ruijter, Marieke, Babbitt, Patricia C, Zhang, Yan Jessie, Whitman, Christian P

“…The tautomerase superfamily (TSF) is a collection of enzymes and proteins that share a simple β–α–β structural scaffold. Most members are constructed from a…”
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Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1 by Eleftheriadis, Nikolaos, Thee, Stephanie, te Biesebeek, Johan, van der Wouden, Petra, Baas, Bert-Jan, Dekker, Frank J.

“…Lipoxygenases metabolize polyunsaturated fatty acids into signalling molecules such as leukotrienes and lipoxins. 15-lipoxygenase-1 (15-LOX-1) is an important…”
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Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily by LeVieux, Jake A., Baas, Bert-Jan, Kaoud, Tamer S., Davidson, Rebecca, Babbitt, Patricia C., Zhang, Yan Jessie, Whitman, Christian P.

“…A Pseudomonas sp. UW4 protein (UniProt K9NIA5) of unknown function was identified as similar to 4-oxalocrotonate tautomerase (4-OT)-like and…”
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