Search Results - "Baarends, W M"

Sequencing of a ‘mouse azoospermia’ gene panel in azoospermic men: identification of RNF212 and STAG3 mutations as novel genetic causes of meiotic arrest by Riera-Escamilla, A, Enguita-Marruedo, A, Moreno-Mendoza, D, Chianese, C, Sleddens-Linkels, E, Contini, E, Benelli, M, Natali, A, Colpi, G M, Ruiz-Castañé, E, Maggi, M, Baarends, W M, Krausz, C

“…Abstract STUDY QUESTION What is the diagnostic potential of next generation sequencing (NGS) based on a ‘mouse azoospermia’ gene panel in human non-obstructive…”
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DNA repair mechanisms and gametogenesis by Baarends, WM, van der Laan, R, Grootegoed, JA

“…In mammals, there is a complex and intriguing relationship between DNA repair and gametogenesis. DNA repair mechanisms are involved not only in the repair of…”
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Evolution of testis‐specific kinases TSSK1B and TSSK2 in primates by Shang, P., Hoogerbrugge, J., Baarends, W. M., Grootegoed, J. A.

“…Summary The testis‐specific serine/threonine protein kinases TSSK1 and TSSK2 are known to be essential for male fertility, in mice. The enzymes are present in…”
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Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages by Liebe, B., Petukhova, G., Barchi, M., Bellani, M., Braselmann, H., Nakano, T., Pandita, T.K., Jasin, M., Fornace, A., Meistrich, M.L., Baarends, W.M., Schimenti, J., de Lange, T., Keeney, S., Camerini-Otero, R.D., Scherthan, H.

“…Meiosis pairs and segregates homologous chromosomes and thereby forms haploid germ cells to compensate the genome doubling at fertilization. Homologue pairing…”
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Anti-müllerian hormone and anti-müllerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin-induced follicle growth by Baarends, W M, Uilenbroek, J T, Kramer, P, Hoogerbrugge, J W, van Leeuwen, E C, Themmen, A P, Grootegoed, J A

“…During fetal development, anti-müllerian hormone (AMH) is produced only by Sertoli cells, but postnatally, granulosa cells also produce this peptide…”
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Specific aspects of the ubiquitin system in spermatogenesis by Baarends, W M, van der Laan, R, Grootegoed, J A

“…The ubiquitin system is involved in numerous cellular processes, regulating the amounts and/or activities of specific proteins through posttranslational…”
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Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification by Roest, H.P, van Klaveren, J, de Wit, J, van Gurp, C.G, Koken, M.H.M, Vermey, M, van Roijen, J.H, Hoogerbrugge, J.W, Vreeburg, J.T.M, Baarends, W.M, Bootsma, D, Grootegoed, J.A, Hoeijmakers, J.H.J

“…The ubiquitin-conjugating yeast enzyme RAD6 and its human homologs hHR6A and hHR6B are implicated in postreplication repair and damage-induced mutagenesis. The…”
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Chromatin dynamics in the male meiotic prophase by Baarends, W M, Grootegoed, J A

“…During the male meiotic prophase in mouse and man, pairing and recombination of homologous chromosomes is accompanied by changes in chromatin structure. In…”
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Immunoexpression of testis-specific histone 2B in human spermatozoa and testis tissue by van Roijen, H J, Ooms, M P, Spaargaren, M C, Baarends, W M, Weber, R F, Grootegoed, J A, Vreeburg, J T

“…During mammalian spermatogenesis, the chromatin of the spermatogenic cells is profoundly reorganized. Somatic histones are partly replaced by testis-specific…”
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A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the mullerian duct by BAARENDS, W. M, VAN HELMOND, M. J. L, THEMMEN, A. P. N, GROOTEGOED, J, POST, M, VAN DER SCHOOT, P. J. C. M, HOOGERBRUGGE, J. W, DE WINTER, J. P, UILENBROEK, J. T. J, KARELS, B, WILMING, L. G, MEIJERS, J. H. C

“…The activin and TGF-beta type II receptors are members of a separate subfamily of transmembrane receptors with intrinsic protein kinase activity, which also…”
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Anti-müllerian hormone and anti-müllerian hormone type II receptor messenger ribonucleic acid expression during postnatal testis development and in the adult testis of the rat by Baarends, W M, Hoogerbrugge, J W, Post, M, Visser, J A, De Rooij, D G, Parvinen, M, Themmen, A P, Grootegoed, J A

“…Anti-müllerian hormone (AMH) induces degeneration of the müllerian ducts during male sex differentiation and may have additional functions concerning gonadal…”
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Characterization of the human androgen receptor transcription unit by FABER, P. W, VAN ROOIJ, H. C. J, VAN DER KORPUT, H. A. G. M, BAARENDS, W. M, BRINKMANN, A. O, GROOTEGOED, J. A, TRAPMAN, J

“…A full length human androgen receptor (hAR) cDNA was constructed from cDNA and genomic clones. Structurally the 10.6-kilobase (kb) hAR cDNA consists of a long…”
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Testis-Specific Expression of a Functional Retroposon Encoding Glucose-6-phosphate Dehydrogenase in the Mouse by Hendriksen, Peter J.M., Hoogerbrugge, Jos W., Baarends, Willy M., de Boer, Peter, Vreeburg, Jan T.M., Vos, Elène A., van der Lende, Tette, Grootegoed, J.Anton

“…The X-chromosomal geneglucose-6-phosphate dehydrogenase(G6pd) is known to be expressed in most cell types of mammalian species. In the mouse, we have detected…”
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Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation by Rijkers, T, Van Den Ouweland, J, Morolli, B, Rolink, A G, Baarends, W M, Van Sloun, P P, Lohman, P H, Pastink, A

“…The RAD52 epistasis group is required for recombinational repair of double-strand breaks (DSBs) and shows strong evolutionary conservation. In Saccharomyces…”
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Histone Ubiquitination and Chromatin Remodeling in Mouse Spermatogenesis by Baarends, Willy M, Hoogerbrugge, Jos W, Roest, Henk P, Ooms, Marja, Vreeburg, Jan, Hoeijmakers, Jan H.J, Grootegoed, J.Anton

“…Male infertility inHR6Bknockout mice is associated with impairment of spermatogenesis. TheHR6Bgene is a mammalian, autosomal homolog of theSaccharomyces…”
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Follitropin receptor down-regulation involves a cAMP-dependent post-transcriptional decrease of receptor mRNA expression by Themmen, A P, Blok, L J, Post, M, Baarends, W M, Hoogerbrugge, J W, Parmentier, M, Vassart, G, Grootegoed, J A

“…The regulation by FSH (follitropin; follicle-stimulating hormone) of FSH receptor mRNA and protein (FSH binding) was studied using cultured Sertoli cells…”
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Molecular and cellular events in spermatogenesis by Grootegoed, J A, Baarends, W M, Hendriksen, P J, Hoogerbrugge, J W, Slegtenhorst-Eegdeman, K E, Themmen, A P

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Transcriptional regulation of androgen receptor gene expression in Sertoli cells and other cell types by Blok, L J, Themmen, A P, Peters, A H, Trapman, J, Baarends, W M, Hoogerbrugge, J W, Grootegoed, J A

“…Regulation of androgen receptor (AR) mRNA expression was studied in Sertoli cells and peritubular myoid cells isolated from immature rat testis, and in the…”
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The rat androgen receptor gene promoter by Baarends, W M, Themmen, A P, Blok, L J, Mackenbach, P, Brinkmann, A O, Meijer, D, Faber, P W, Trapman, J, Grootegoed, J A

“…The androgen receptor (AR) is activated upon binding of testosterone or dihydrotestosterone and exerts regulatory effects on gene expression in androgen target…”
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Molecular and cellular mechanisms in spermatogenesis by Grootegoed, J.Anton, Siep, Michel, Baarends, Willy M.

“…Mammalian spermatogenesis shows a strict control of many specific molecular and cellular events. This control involves Sertoli cell–germ cell interaction, as…”
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