Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. Forty rats were divided into four groups as control, control + EA...

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Bibliographic Details
Published in:Pharmacognosy Magazine Vol. 7; no. 27; pp. 224 - 228
Main Authors: Böyük, Abdullah, Onder, Akin, Kapan, Murat, Gümüş, Metehan, Fιrat, Uğur, Başaralι, Mustafa Kemal, Alp, Harun
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-07-2011
Sage Publications Ltd
Medknow Publications Pvt Ltd
Subjects:
Antioxidants
Apoptosis
Care and treatment
Diagnosis
Ellagic acid
Gene expression
Health aspects
Intestinal ischemia
Ischemia
Laboratory animals
Nutrition
Original
Oxidative stress
Proteins
Risk factors
Rodents
Signal transduction
Studies
Wounds and injuries
United States
total oxidative status
malondialdehyde
total antioxidant capacity
Ellagic acid
ιntestinal ischemia reperfusion
oxidative stress index
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Summary:The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy. TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group. These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.
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ISSN:0973-1296
0976-4062
DOI:10.4103/0973-1296.84236