Search Results - "Bařinka, Cyril"

A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging by Zhang, Jingming, Rakhimbekova, Anastasia, Duan, Xiaojiang, Yin, Qingqing, Foss, Catherine A., Fan, Yan, Xu, Yangyang, Li, Xuesong, Cai, Xuekang, Kutil, Zsofia, Wang, Pengyuan, Yang, Zhi, Zhang, Ning, Pomper, Martin G., Wang, Yiguang, Bařinka, Cyril, Yang, Xing

“…Surgery is an efficient way to treat localized prostate cancer (PCa), however, it is challenging to demarcate rapidly and accurately the tumor boundary…”
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Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models by Shen, Sida, Hadley, Melissa, Ustinova, Kseniya, Pavlicek, Jiri, Knox, Tessa, Noonepalle, Satish, Tavares, Mauricio T, Zimprich, Chad A, Zhang, Guiping, Robers, Matthew B, Bařinka, Cyril, Kozikowski, Alan P, Villagra, Alejandro

“…Isoxazole is a five-membered heterocycle that is widely used in drug discovery endeavors. Here, we report the design, synthesis, and structural and biological…”
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Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor by Shen, Sida, Svoboda, Michal, Zhang, Guangming, Cavasin, Maria A, Motlova, Lucia, McKinsey, Timothy A, Eubanks, James H, Bařinka, Cyril, Kozikowski, Alan P

“…Tubastatin A, a tetrahydro-γ-carboline-capped selective HDAC6 inhibitor (HDAC6i), was rationally designed 10 years ago, and has become the best investigated…”
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Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model by Shen, Sida, Picci, Cristina, Ustinova, Kseniya, Benoy, Veronick, Kutil, Zsófia, Zhang, Guiping, Tavares, Maurício T, Pavlíček, Jiří, Zimprich, Chad A, Robers, Matthew B, Van Den Bosch, Ludo, Bařinka, Cyril, Langley, Brett, Kozikowski, Alan P

“…Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6…”
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Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models by Noonepalle, Satish, Shen, Sida, Ptáček, Jakub, Tavares, Maurício T, Zhang, Guiping, Stránský, Jan, Pavlíček, Jiří, Ferreira, Glaucio M, Hadley, Melissa, Pelaez, Guido, Bařinka, Cyril, Kozikowski, Alan P, Villagra, Alejandro

“…Selective inhibition of histone deacetylase 6 (HDAC6) is being recognized as a therapeutic approach for cancers. In this study, we designed a new HDAC6…”
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One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity by Zessin, Matthes, Kutil, Zsófia, Meleshin, Marat, Nováková, Zora, Ghazy, Ehab, Kalbas, Diana, Marek, Martin, Romier, Christophe, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike

“…We developed a one-step direct assay for the determination of histone deacylase (HDAC) activity by substituting the carbonyl oxygen of the acyl moiety with…”
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Development of 5D3-DM1: A Novel Anti-Prostate-Specific Membrane Antigen Antibody-Drug Conjugate for PSMA-Positive Prostate Cancer Therapy by Huang, Colin T, Guo, Xin, Bařinka, Cyril, Lupold, Shawn E, Pomper, Martin G, Gabrielson, Kathleen, Raman, Venu, Artemov, Dmitri, Hapuarachchige, Sudath

“…Prostate cancer (PC) is a potentially high-risk disease and the most common cancer in American men. It is a leading cause of cancer-related deaths in men in…”
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Predicting Effects of Site-Directed Mutagenesis on Enzyme Kinetics by QM/MM and QM Calculations: A Case of Glutamate Carboxypeptidase II by Bím, Daniel, Navrátil, Michal, Gutten, Ondrej, Konvalinka, Jan, Kutil, Zsófia, Culka, Martin, Navrátil, Václav, Alexandrova, Anastassia N, Bařinka, Cyril, Rulíšek, Lubomír

“…Quantum and molecular mechanics (QM/MM) and QM-only (cluster model) modeling techniques represent the two workhorses in mechanistic understanding of enzyme…”
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Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome by Kozikowski, Alan P, Shen, Sida, Pardo, Marta, Tavares, Maurício T, Szarics, Dora, Benoy, Veronick, Zimprich, Chad A, Kutil, Zsófia, Zhang, Guiping, Bařinka, Cyril, Robers, Matthew B, Van Den Bosch, Ludo, Eubanks, James H, Jope, Richard S

“…Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a…”
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Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms by Zessin, Matthes, Meleshin, Marat, Praetorius, Lucas, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike

“…Zinc-dependent histone deacetylases (HDACs) and sirtuins (SIRT) represent two different classes of enzymes which are responsible for deacylation of modified…”
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Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain by Rais, Rana, Vávra, Jan, Tichý, Tomáš, Dash, Ranjeet P, Gadiano, Alexandra J, Tenora, Lukáš, Monincová, Lenka, Bařinka, Cyril, Alt, Jesse, Zimmermann, Sarah C, Slusher, C. Ethan, Wu, Ying, Wozniak, Krystyna, Majer, Pavel, Tsukamoto, Takashi, Slusher, Barbara S

“…4-Carboxy-α-[3-(hydroxyamino)-3-oxopropyl]-benzenepropanoic acid 1 is a potent hydroxamate-based inhibitor of glutamate carboxypeptidase II. In an attempt to…”
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Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6) by Motlová, Lucia, Šnajdr, Ivan, Kutil, Zsófia, Andris, Erik, Ptáček, Jakub, Novotná, Adéla, Nováková, Zora, Havlínová, Barbora, Tueckmantel, Werner, Dráberová, Helena, Majer, Pavel, Schutkowski, Mike, Kozikowski, Alan, Rulíšek, Lubomír, Bařinka, Cyril

“…Histone deacetylase (HDAC) inhibitors used in the clinic typically contain a hydroxamate zinc-binding group (ZBG). However, more recent work has shown that the…”
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Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein by Kravec, Marek, Šedo, Ondrej, Nedvědová, Jana, Micka, Miroslav, Šulcová, Marie, Zezula, Nikodém, Gömöryová, Kristína, Potěšil, David, Sri Ganji, Ranjani, Bologna, Sara, Červenka, Igor, Zdráhal, Zbyněk, Harnoš, Jakub, Tripsianes, Konstantinos, Janke, Carsten, Bařinka, Cyril, Bryja, Vítězslav

“…Polyglutamylation is a reversible posttranslational modification that is catalyzed by enzymes of the tubulin tyrosine ligase-like (TTLL) family. Here, we found…”
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Development and therapeutic evaluation of 5D3(CC-MLN8237) 3.2 antibody-theranostic conjugates for PSMA-positive prostate cancer therapy by Liatsou, Ioanna, Assefa, Betelhem, Liyanage, Wathsala, Surasinghe, Sharmane, Nováková, Zora, Bařinka, Cyril, Gabrielson, Kathleen, Raman, Venu, Artemov, Dmitri, Hapuarachchige, Sudath

“…Prostate cancer (PC) is an aggressive cancer that can progress rapidly and eventually become castrate-resistant prostate cancer (CRPC). Stage IV metastatic…”
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The Avian Retroviral Receptor Tva Mediates the Uptake of Transcobalamin Bound Vitamin B 12 (Cobalamin) by Krchlíková, Veronika, Mikešová, Jana, Geryk, Josef, Bařinka, Cyril, Nexo, Ebba, Fedosov, Sergey N., Kosla, Jan, Kučerová, Dana, Reinišová, Markéta, Hejnar, Jiří, Elleder, Daniel

“…We demonstrate that the ASLV receptor Tva participates in the physiological uptake of TC-Cbl because the viral infection suppresses the uptake of Cbl and vice…”
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Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors by Kutil, Zsófia, Mikešová, Jana, Zessin, Matthes, Meleshin, Marat, Nováková, Zora, Alquicer, Glenda, Kozikowski, Alan, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike

“…Histone deacetylase 11 (HDAC11) preferentially removes fatty acid residues from lysine side chains in a peptide or protein environment. Here, we report the…”
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Cellular Delivery of Bioorthogonal Pretargeting Therapeutics in PSMA-Positive Prostate Cancer by Hapuarachchige, Sudath, Huang, Colin T, Donnelly, Madeline C, Bařinka, Cyril, Lupold, Shawn E, Pomper, Martin G, Artemov, Dmitri

“…Prostate cancer is primarily fatal after it becomes metastatic and castration-resistant despite novel combined hormonal and chemotherapeutic regimens. Hence,…”
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Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models by Tavares, Maurício T, Shen, Sida, Knox, Tessa, Hadley, Melissa, Kutil, Zsófia, Bařinka, Cyril, Villagra, Alejandro, Kozikowski, Alan P

“…Only a handful of therapies offer significant improvement in the overall survival in cases of melanoma, a cancer whose incidence has continued to rise in the…”
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2‑Aminoadipic Acid–C(O)–Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics by Nakajima, Ryo, Nováková, Zora, Tueckmantel, Werner, Motlová, Lucia, Bařinka, Cyril, Kozikowski, Alan P

“…The design and synthesis of prostate specific membrane antigen (PSMA) ligands derived from 2-aminoadipic acid, a building block that has not previously been…”
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Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine by Tykvart, Jan, Bařinka, Cyril, Svoboda, Michal, Navrátil, Václav, Souček, Radko, Hubálek, Martin, Hradilek, Martin, Šácha, Pavel, Lubkowski, Jacek, Konvalinka, Jan

“…N-acetylated α-linked acidic dipeptidase-like protein (NAALADase L), encoded by the NAALADL1 gene, is a close homolog of glutamate carboxypeptidase II, a…”
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