Search Results - "Bañales, J M"
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Mechanisms of Resistance to Chemotherapy in Gastric Cancer
Published in Anti-cancer agents in medicinal chemistry (01-01-2016)“…Although surgical resection is the standard curative therapy for gastric cancer, these tumors are often diagnosed at an advanced stage, when surgery is not…”
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Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
Published in Nature communications (23-01-2020)“…The number of patients diagnosed with chronic bile duct disease is increasing and in most cases these diseases result in chronic ductular scarring,…”
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Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism
Published in Antimicrobial agents and chemotherapy (01-07-2014)“…Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic…”
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Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2–STAT3, NF-κB, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions
Published in Biochemical genetics (01-12-2015)“…Breast cancer is the most frequent neoplasia in women and is responsible for approximately 13.8% of deaths per year for this gender. It has been suggested that…”
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MicroRNAs and extracellular vesicles in cholangiopathies
Published in Biochimica et biophysica acta. Molecular basis of disease (01-04-2018)“…Cholangiopathies encompass a heterogeneous group of disorders affecting biliary epithelial cells (i.e. cholangiocytes). Early diagnosis, prognosis and…”
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S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes
Published in Biochimica et biophysica acta. Molecular basis of disease (01-11-2020)“…S-adenosyl-L-methionine is an endogenous molecule with hepato-protective properties linked to redox regulation and methylation. Here, the potential therapeutic…”
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Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
Published in Biochimica et biophysica acta. Molecular basis of disease (01-04-2018)“…Cholangiocarcinoma (CCA) is an aggressive tumor type affecting cholangiocytes. CCAs frequently arise under certain cholestatic liver conditions. Intrahepatic…”
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Prevalence and Factors Associated With Fatigue in Patients With Inflammatory Bowel Disease: A Multicentre Study
Published in Journal of Crohn's and colitis (14-08-2019)“…The aims of this study were to determine the prevalence of fatigue in patients with inflammatory bowel disease [IBD], to identify the factors associated with…”
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New Advances in Polycystic Liver Diseases
Published in Seminars in liver disease (01-02-2017)“…Polycystic liver diseases (PLDs) include a heterogeneous group of congenital disorders inherited as dominant or recessive genetic traits; they are manifested…”
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New evidence supporting the biliary bicarbonate umbrella theory
Published in Clinics and research in hepatology and gastroenterology (01-03-2017)Get full text
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Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2-STAT3, NF-[kappa]B, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions
Published in Biochemical genetics (01-12-2015)“…Breast cancer is the most frequent neoplasia in women and is responsible for approximately 13.8% of deaths per year for this gender. It has been suggested that…”
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P275 Clinical characteristics, associated malignancies and management of primary sclerosing colangitis in inflammatory bowel disease patients: A Spanish nationwide study based on the ENEIDA registry
Published in Journal of Crohn's and colitis (16-01-2018)“…Abstract Background Primary sclerosing colangitis (PSC) is a chronic cholestasic liver disease usually associated with inflammatory bowel disease (IBD). An…”
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Polycystic liver in the adult (PLA) in Spain: analysis of a structured survey analyzing the experience and attitude of gastroenterologists in Spain
Published in Revista española de enfermedades digestivas (01-04-2014)“…Polycystic liver in the adult (PLA) is a rare disease characterized by chronic liver enlargement. To analyse gastroenterologists´ involvement in, experience…”
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Genomewide Association Study of Severe Covid-19 with Respiratory Failure
Published in The New England journal of medicine (15-10-2020)“…During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained…”
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Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
Published in The Journal of clinical investigation (01-12-2021)“…BACKGROUND. There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition…”
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Novel genes and sex differences in COVID-19 severity
Published in Human molecular genetics (2022)“…Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from…”
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A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans
Published in Hepatology (Baltimore, Md.) (01-09-2023)“…Cholestasis is characterized by intrahepatic accumulation of bile constituents, including bile acids (BAs), which promote liver damage. The apical…”
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Molecular mechanisms in bile formation
Published in Gastroenterología y hepatología (01-05-2004)Get more information
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SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma
Published in Journal of hepatology (01-07-2017)“…Graphical abstract…”
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Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA
Published in Hepatology (Baltimore, Md.) (01-06-2024)“…Alagille syndrome (ALGS) is characterized by chronic cholestasis with associated pruritus and extrahepatic anomalies. Maralixibat, an ileal bile acid…”
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