Anticancer platinum‐based complexes with non‐classical structures

Although classical platinum drugs such as cisplatin, carboplatin and oxaliplatin play a vitally important role in cancer treatment, nonselective distribution of platinum drugs in normal and tumor cells can induce serious gastrointestinal reaction, nephrotoxicity, ototoxicity, neurotoxicity and cross...

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Bibliographic Details
Published in:	Applied organometallic chemistry Vol. 32; no. 4
Main Authors:	Cai, Linxiang, Yu, Congtao, Ba, Linkui, Liu, Qinghua, Qian, Yunxu, Yang, Bo, Gao, Chuanzhu
Format:	Journal Article
Language:	English
Published:	Chichester Wiley Subscription Services, Inc 01-04-2018
Subjects:	anticancer Cancer Chemistry drug delivery In vivo methods and tests multinuclear non‐classical Platinum
Online Access:	Get full text
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Summary:	Although classical platinum drugs such as cisplatin, carboplatin and oxaliplatin play a vitally important role in cancer treatment, nonselective distribution of platinum drugs in normal and tumor cells can induce serious gastrointestinal reaction, nephrotoxicity, ototoxicity, neurotoxicity and cross resistance, limiting their applications. Over the past few years, a great number of platinum complexes of non‐classical structures have been extensively investigated and evaluated in vitro and in vivo, some of them exhibiting considerable activity. In this review, platinum‐based complexes with non‐classical structures which have anticancer potential are described and several representative examples are discussed with their mechanism of action. Classical platinum drugs play an important role in treatment of solid neoplasms, but have various defects such as toxic side effects and drug resistance. Therefore, the search for less toxic and more effective novel platinum derivatives is the subject of intensive research. This review reports non‐classical platinum complexes with their structures and characteristics for overcoming some difficult problems in cancer treatment, to maximize antitumor effect and minimize toxic side effects and drug resistance.
ISSN:	0268-2605 1099-0739
DOI:	10.1002/aoc.4228