Search Results - "BYRN, R"

Synthesis, Characterization, and Stability Assessment for the Benzoate, Hydrochloride, Malonate, and Nicotinate Salts of Bedaquiline by Okezue, Mercy A, Byrn, Stephen R

“…Bedaquiline has been approved as a combination therapy to treat multi-drug-resistant tuberculosis in adults ≥ 18 years old. The citrate, fumarate, phosphate,…”
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Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions by Nie, Haichen, Su, Yongchao, Zhang, Mingtao, Song, Yang, Leone, Anthony, Taylor, Lynne S, Marsac, Patrick J, Li, Tonglei, Byrn, Stephen R

“…It has been technically challenging to specify the detailed molecular interactions and binding motif between drugs and polymeric inhibitors in the solid state…”
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Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation by Nie, Haichen, Xu, Wei, Taylor, Lynne S., Marsac, Patrick J., Byrn, Stephen R.

“…[Display omitted] Salt disproportionation (a conversion from the ionized to the neutral state) in solid formulations is a potential concern during…”
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Potency and Powder X-ray Diffraction (PXRD) Evaluation of Levothyroxine Sodium Tablets under Ambient, Accelerated, and Stressed Conditions by Okezue, Mercy A, Byrn, Stephen R, Probost, Josiah, Lucas, Madison, Clase, Kari L

“…Levothyroxine tablets, although highly prescribed in the United States, have been one of the most frequently recalled products. Because of the importance of…”
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Investigating the Interaction Pattern and Structural Elements of a Drug–Polymer Complex at the Molecular Level by Nie, Haichen, Mo, Huaping, Zhang, Mingtao, Song, Yang, Fang, Ke, Taylor, Lynne S, Li, Tonglei, Byrn, Stephen R

“…Strong associations between drug and polymeric carriers are expected to contribute to higher drug loading capacities and better physical stability of amorphous…”
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Acoustic levitation and high-resolution synchrotron X-ray powder diffraction: A fast screening approach of niclosamide amorphous solid dispersions by Barbosa, Eduardo J., Andrade, Marco A.B., Gubitoso, Mariana R., Bezzon, Vinícius D.N., Smith, Pamela A., Byrn, Stephen R., Bou-Chacra, Nádia A., Carvalho, Flavio M.S., de Araujo, Gabriel L.B.

“…[Display omitted] •Niclosamide-polymer drops were levitated in a multi-emitter acoustic levitator.•Crystallization was real-time evaluated by high-resolution…”
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Hydrogen Bonding in Amorphous Indomethacin by Benmore, C J, Yarger, J L, Davidowski, S K, Shrader, C D, Smith, P A, Byrn, S R

“…Amorphous Indomethacin has enhanced bioavailability over its crystalline forms, yet amorphous forms can still possess a wide variety of structures. Here,…”
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Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations by Nie, Haichen, Xu, Wei, Ren, Jie, Taylor, Lynne S, Marsac, Patrick J, John, Christopher T, Byrn, Stephen R

“…Excipient-induced salt disproportionation (conversion from salt form to free form) in the solid state during storage or manufacturing is a severe formulation…”
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Chemical reactivity in solid-state pharmaceuticals: formulation implications by Byrn, Stephen R, Xu, Wei, Newman, Ann W

“…Solid-state reactions that occur in drug substances and formulations include solid-state phase transformations, dehydration/desolvation, and chemical…”
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Accelerated Development of Pharmaceuticals Past, Present, and Future by Byrn, Stephen R.

“…This paper reviews the accelerated development of pharmaceuticals, exploring past, present, and future perspectives. It provides a historical overview of early…”
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Structural characterization and aging of glassy pharmaceuticals made using acoustic levitation by Benmore, Chris J, Weber, J K R, Tailor, Amit N, Cherry, Brian R, Yarger, Jeffery L, Mou, Qiushi, Weber, Warner, Neuefeind, Joerg, Byrn, Stephen R

“…Here, we report the structural characterization of several amorphous drugs made using the method of quenching molten droplets suspended in an acoustic…”
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Solid-state analysis of the active pharmaceutical ingredient in drug products by Newman, Ann W., Byrn, Stephen R.

“…The solid form of a drug substance is important when developing a new chemical entity. The crystalline form used in development is significant based on…”
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Solid-state nuclear magnetic resonance spectroscopy--pharmaceutical applications by Tishmack, Patrick A, Bugay, David E, Byrn, Stephen R

“…Solid-state nuclear magnetic resonance (NMR) spectroscopy has become an integral technique in the field of pharmaceutical sciences. This review focuses on the…”
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Acoustic levitation: recent developments and emerging opportunities in biomaterials research by Weber, Richard J. K., Benmore, Chris J., Tumber, Sonia K., Tailor, Amit N., Rey, Charles A., Taylor, Lynne S., Byrn, Stephen R.

“…Containerless sample environments (levitation) are useful for study of nucleation, supercooling, and vitrification and for synthesis of new materials, often…”
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Maleate salts of bedaquiline by Zeller, Matthias, Bogdanowich-Knipp, Susan, Smith, Pamela, Purcell, Dale K, Okezue, Mercy, Smith, Daniel T, Byrn, Stephen R, Clase, Kari L

“…Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt, but only a…”
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Accelerating proof of concept for small molecule drugs using solid-state chemistry by Byrn, Stephen R, Zografi, George, Chen, Xiaoming Sean

“…In this perspective we have shown that the process of "proof of concept" (POC) in the early part of drug development can be greatly accelerated by close…”
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Solid state interconversion between anhydrous norfloxacin and its hydrates by Chongcharoen, Wanchai, Byrn, Stephen R, Sutanthavibul, Narueporn

“…This work is focused on characterizing and evaluating the solid state interconversion of norfloxacin (NF) hydrates. Four stoichiometric NF hydrates, dihydrate,…”
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Molecular Mechanism of Crystalline-to-Amorphous Conversion of Pharmaceutical Solids from 19F Magic Angle Spinning NMR by Lu, Xingyu, Huang, Chengbin, Li, Mingyue, Skomski, Daniel, Xu, Wei, Yu, Lian, Byrn, Stephen R, Templeton, Allen C, Su, Yongchao

“…Crystalline and amorphous materials usually possess distinct physicochemical properties due to major variations in long-range and local molecular packings…”
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Theoretical and Experimental Considerations on the Enthalpic Relaxation of Organic Glasses using Differential Scanning Calorimetry by Mao, Chen, Chamarthy, Sai Prasanth, Byrn, Stephen R, Pinal, Rodolfo

“…The enthalpy relaxation of amorphous salicin, used as model organic glass of pharmaceutical relevance, was investigated using a combination of DSC measurements…”
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Thermochemistry and Conformational Polymorphism of a Hexamorphic Crystal System by Yu, Lian, Stephenson, Gregory A, Mitchell, Christine A, Bunnell, Charles A, Snorek, Sharon V, Bowyer, J. Joe, Borchardt, Thomas B, Stowell, Joseph G, Byrn, Stephen R

“…5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile has been crystallized as six solvent-free polymorphs, which differ in the mode of packing and in…”
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