Search Results - "BUYUKBINGOL, Erdem"

Novel indole retinoid derivative induces apoptosis and cell cycle arrest and modulates AKT and ERK signaling in HL‐60 cells by Gurkan‐Alp, A. Selen, Karabay, Arzu Z., Koc, Asli, Buyukbingol, Erdem

“…Chemotherapy with targeted drugs is the first line therapy option for acute and chronic myeloid leukemia. However, hematopoietic stem cell transplantation may…”
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Recent studies of aldose reductase enzyme inhibition for diabetic complications by Suzen, Sibel, Buyukbingol, Erdem

“…Aldose reductase [ALR2; EC 1.1.1.21], a key enzyme of polyol pathway, catalyzes NADPH-dependent reduction of glucose to sorbitol (Sorbitol pathway), and an…”
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Adaptive neuro-fuzzy inference system (ANFIS): A new approach to predictive modeling in QSAR applications: A study of neuro-fuzzy modeling of PCP-based NMDA receptor antagonists by Buyukbingol, Erdem, Sisman, Arzu, Akyildiz, Murat, Alparslan, Ferda Nur, Adejare, Adeboye

“…This paper proposes a new method, Adaptive Neuro-Fuzzy Inference System (ANFIS) to evaluate physicochemical descriptors of certain chemical compounds for their…”
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Antimicrobial activities of some tetrahydronaphthalene-benzimidazole derivatives by Ates-Alagoz, Zeynep, Yildiz, Sulhiye, Buyukbingol, Erdem

“…Novel retinoid derivatives containing a benzimidazole moiety were synthesized and tested for their antimicrobial activity. Their antimicrobial activities…”
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Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages by Gurkan, A. Selen, Karabay, Arzu Z., Buyukbingol, Zeliha, Buyukbingol, Erdem

“…In this study, novel N-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-yl)-carboxamide ( 6– 15) and…”
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Natural Products for Anti-Cancer Progress: The Impact of Artificial Intelligence by Erdem Buyukbingol

“…Finding for more effective anticancer drugs on almost different types of cancer, a huge number of molecules is still under evaluation and barely many more than…”
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Identification of Potential Aldose Reductase Inhibitors Using Convolutional Neural Network-Based in Silico Screening by Kashyap, Kushagra, Mahapatra, Pinaki Prasad, Ahmed, Shakil, Buyukbingol, Erdem, Siddiqi, Mohammad Imran

“…Aldose reductase (ALR2) is a notable enzyme of the polyol pathway responsible for aggravating diabetic neuropathy complications. The first step begins when it…”
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Antioxidant Properties of Novel Benzimidazole Retinoids by Ates-Alagoz, Zeynep, Can-Eke, Benay, Coban, Tulay, Iscan, Mumtaz, Buyukbingol, Erdem

“…Our approach was to examine the antioxidant activity of novel retinoid derivatives containing the benzimidazole moiety. Their in vitro effects on rat liver…”
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Three-Dimensional Analysis of Binding Sites for Predicting Binding Affinities in Drug Design by Erdas-Cicek, Ozlem, Atac, Ali Osman, Gurkan-Alp, A. Selen, Buyukbingol, Erdem, Alpaslan, Ferda Nur

“…Understanding the interaction between drug molecules and proteins is one of the main challenges in drug design. Several tools have been developed recently to…”
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An application of CIFAP for predicting the binding affinity of Chk1 inhibitors derived from 2‐aminothiazole‐4‐carboxamide by Konyar, Dilan, Erdas, Ozlem, Alpaslan, Ferda Nur, Buyukbingol, Erdem

“…Investigation of protein‐ligand interactions obtained from experiments has a crucial part in the design of newly discovered and effective drugs. Analyzing the…”
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Retinoid N-(1H-benzo[d]imidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cells by Mumcuoglu, Mine, Gurkan-Alp, A. Selen, Buyukbingol, Erdem, Cetin-Atalay, Rengul

“…[Display omitted] •27 novel retinoids were tested on breast cancer cells for their cytotoxicity.•Compound 17 induced p21-dependent cell death, reminiscent of…”
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Crystal Structure of the Dipeptide Cyclo(glycyl- L -glutamine) by CAIRA, Mino R., BUYUKBINGOL, Erdem, ADEJARE, Adeboye ADEJARE Adeboye, MILLINGTON, William R.

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Crystal Structure of 2-[(5′,6′,7′,8′-Tetrahydro-5′,5′,8′,8′-tetramethyl)-2′-naphthyl]-1-ethyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester by KENDI, Engin, ATES-ALAGOZ, Zeynep, SUZEN, Sibel, BUYUKBINGOL, Erdem

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Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives by Gurkan-Alp, A. Selen, Mumcuoglu, Mine, Andac, Cenk A., Dayanc, Emre, Cetin-Atalay, Rengul, Buyukbingol, Erdem

“…In this study, novel (E)-3-(5-substituted-1H-indol-3-yl)-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one (5(a–e)) derivatives were…”
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Inhibitory effects of indole [alpha]-lipoic acid derivatives on nitric oxide production in LPS/IFN[gamma] activated RAW 264.7 macrophages by Karabay, Arzu Zeynep, Koc, Asli, Gurkan-Alp, A Selen, Buyukbingol, Zeliha, Buyukbingol, Erdem

“…Alpha-lipoic acid ([alpha]-lipoic acid) is a potent antioxidant compound that has been shown to possess anti-inflammatory effects. RAW 264.7 macrophages…”
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Compressed images for affinity prediction-2 (CIFAP-2): an improved machine learning methodology on protein-ligand interactions based on a study on caspase 3 inhibitors by Erdas, Ozlem, Andac, Cenk A, Gurkan-Alp, A Selen, Alpaslan, Ferda Nur, Buyukbingol, Erdem

“…The aim of this study is to propose an improved computational methodology, which is called Compressed Images for Affinity Prediction-2 (CIFAP-2) to predict…”
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Modeling and predicting binding affinity of phencyclidine-like compounds using machine learning methods by Erdas, Ozlem, Buyukbingol, Erdem, Alpaslan, Ferda Nur, Adejare, Adeboye

“…Machine learning methods have always been promising in the science and engineering fields, and the use of these methods in chemistry and drug design has…”
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Inhibitory effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFNγ activated RAW 264.7 macrophages by Karabay, Arzu Zeynep, Koc, Aslı, Gurkan-Alp, A. Selen, Buyukbingol, Zeliha, Buyukbingol, Erdem

“…Alpha‐lipoic acid (α‐lipoic acid) is a potent antioxidant compound that has been shown to possess anti‐inflammatory effects. RAW 264.7 macrophages produce…”
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Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles by Ates-Alagöz, Zeynep, Alp, Mehmet, Kus, Canan, Yildiz, Sulhiye, Buyukbingöl, Erdem, Göker, Hakan

“…Several 2‐(5,5,8,8‐tetramethyl‐5,6,7,8‐tetrahydronaphthalen‐2‐yl)‐1H‐benzimidazole‐5‐carboxamidine analogues were synthesized for their antibacterial and…”
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Synthesis and antimicrobial activity of new tetrahydro-naphthalene-thiazolidinedione and thiohydantoine derivatives by Ates-Alagoz, Zeynep, Altanlar, Nurten, Buyukbingol, Erdem

“…As part of an ongoing program aimed at recognizing novel antioxidant, antimicrobial, and anticancer molecules, herein we report the synthesis and biological…”
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