Search Results - "BUTZOW, Ralf"

Methylation in Predicting Progression of Untreated High-grade Cervical Intraepithelial Neoplasia by Louvanto, Karolina, Aro, Karoliina, Nedjai, Belinda, Bützow, Ralf, Jakobsson, Maija, Kalliala, Ilkka, Dillner, Joakim, Nieminen, Pekka, Lorincz, Attila

“…Abstract Background There is no prognostic test to ascertain whether cervical intraepithelial neoplasias (CINs) regress or progress. The majority of CINs…”
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Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors by Mäkinen, Netta, Kämpjärvi, Kati, Frizzell, Norma, Bützow, Ralf, Vahteristo, Pia

“…Uterine smooth muscle tumors range from benign leiomyomas to malignant leiomyosarcomas. Based on numerous molecular studies, leiomyomas and leiomyosarcomas…”
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Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12 by Mäkinen, Netta, Aavikko, Mervi, Heikkinen, Tuomas, Taipale, Minna, Taipale, Jussi, Koivisto-Korander, Riitta, Bützow, Ralf, Vahteristo, Pia

“…Uterine leiomyosarcomas (ULMSs) are aggressive smooth muscle tumors associated with poor clinical outcome. Despite previous cytogenetic and molecular studies,…”
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Clinical factors as prognostic variables among molecular subgroups of endometrial cancer by Kolehmainen, Anne, Pasanen, Annukka, Tuomi, Taru, Koivisto-Korander, Riitta, Bützow, Ralf, Loukovaara, Mikko

“…Clinical factors may influence endometrial cancer survival outcomes. We examined the prognostic significance of age, body mass index (BMI), and type 2 diabetes…”
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Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer by Kiiski, Johanna I., Pelttari, Liisa M., Khan, Sofia, Freysteinsdottir, Edda S., Reynisdottir, Inga, Hart, Steven N., Shimelis, Hermela, Vilske, Sara, Kallioniemi, Anne, Schleutker, Johanna, Leminen, Arto, Bützow, Ralf, Blomqvist, Carl, Barkardottir, Rosa B., Couch, Fergus J., Aittomäki, Kristiina, Nevanlinna, Heli

“…Significance The major portion of hereditary breast cancer still remains unexplained, and many susceptibility loci are yet to be found. Exome sequencing of 24…”
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Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers by Deng, Shan, Yang, Xiaojun, Lassus, Heini, Liang, Shun, Kaur, Sippy, Ye, Qunrui, Li, Chunsheng, Wang, Li-Ping, Roby, Katherine F, Orsulic, Sandra, Connolly, Denise C, Zhang, Youcheng, Montone, Kathleen, Bützow, Ralf, Coukos, George, Zhang, Lin

“…Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of cancer stem cells. However, our knowledge of the expression and…”
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Activation of vestibule-associated lymphoid tissue in localized provoked vulvodynia by Tommola, Päivi, MD, Bützow, Ralf, MD, PhD, Unkila-Kallio, Leila, MD, PhD, Paavonen, Jorma, MD, PhD, Meri, Seppo, MD, PhD

“…Objective Localized provoked vulvodynia (LPV) may have inflammatory etiology. We wanted to find out whether the cell-mediated immune system becomes activated…”
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Characteristics and outcome of recurrence in molecularly defined adult-type ovarian granulosa cell tumors by Bryk, Saara, MD, Färkkilä, Anniina, MD, PhD, Bützow, Ralf, MD, PhD, Leminen, Arto, MD, PhD, Tapper, Johanna, MD, PhD, Heikinheimo, Markku, MD, PhD, Unkila-Kallio, Leila, MD, PhD, Riska, Annika, MD, PhD

“…Abstract Objective Adult-type ovarian granulosa cell tumors (AGCTs) have an unpredictable tendency to relapse. In a carefully validated patient cohort, we…”
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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer by Riggan, Marjorie J, Beesley, Jonathan, Soucy, Penny, Aalfs, Cora M, Adams, Marcia, Arnold, Norbert, Arun, Banu K, Bean, Yukie, Bermisheva, Marina, Birrer, Michael J, Blankstein, Kenneth, Bonanni, Bernardo, Bradbury, Angela R, Broberg, Per, Campbell, Ian, Cannioto, Rikki, Cescon, Terence, Chan, Salina B, Chanock, Stephen, Claes, Kathleen B M, Conner, Thomas, Dansonka-Mieszkowska, Agnieszka, Davidson, Rosemarie, Dürst, Matthias, Ellis, Steve, Fasching, Peter A, Ferguson, Sarah, Frost, Debra, Gentry-Maharaj, Aleksandra, Gore, Martin, Gronwald, Jacek, Gruber, Stephen, Håkansson, Niclas, Hauke, Jan, Hildebrandt, Michelle A T, Høgdall, Claus K, Hogervorst, Frans B L, Hulick, Peter J, Imyanitov, Evgeny N, Izatt, Louise, Izquierdo, Angel, Jensen, Allan, Karnezis, Anthony, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lee, Jong Won, Lele, Shashikant B, Leroux, Dominique, Lesueur, Fabienne, Lilyquist, Jenna, Mai, Phuong L, McAlpine, Jessica N, McGuire, Valerie, Mensenkamp, Arjen R, Modugno, Francesmary, Moes-Sosnowska, Joanna, Mulligan, Anna Marie, Musinsky, Jacob, Nedergaard, Lotte, Ness, Roberta B, Nevanlinna, Heli, Niederacher, Dieter, Nussbaum, Robert L, Onland-Moret, N Charlotte, Paul, James, Pelttari, Liisa M, Pezzani, Lidia, Phillips, Kelly-Anne, Poppe, Bruce, Prieur, Fabienne, Prokofyeva, Darya, Rice, Patricia, Rodriguez, Gustavo C, Rookus, Matti A, Senter, Leigha, Shelford, Tameka, Siddiqui, Nadeem, Side, Lucy E, Stadler, Zsofia, Sutphen, Rebecca, Sutter, Christian, Szabo, Csilla I, Terry, Kathryn L, Tihomirova, Laima, Tung, Nadine, Van Heetvelde, Mattias, Varon-Mateeva, Raymonda, Walsh, Christine, Wappenschmidt, Barbara, Webb, Penelope M, Weinberg, Clarice R, Weitzel, Jeffrey N, Yang, Hannah, Goodman, Marc T, Park, Sue K, Risch, Harvey A, Offit, Kenneth, Simard, Jacques, Chenevix-Trench, Georgia, Goode, Ellen L

“…Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different…”
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Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells by XIAOJUN YANG, XIAOJUAN LIN, XIA ZHAO, YOUCHENG ZHANG, BÜTZOW, Ralf, COUKOS, George, LIN ZHANG, XIAOMIN ZHONG, KAUR, Sippy, NING LI, SHUN LIANG, LASSUS, Heini, LIPING WANG, KATSAROS, Dionyssios, MONTONE, Kathleen

“…A relatively rare aldehyde dehydrogenase 1 (ALDH1)-positive "stem cell-like" subpopulation of tumor cells has the unique ability to initiate and perpetuate…”
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Histopathologic and Molecular Characterization of Uterine Leiomyoma–like Inflammatory Myofibroblastic Tumor: Comparison to Molecular Subtypes of Uterine Leiomyoma by Kuisma, Heli, Jokinen, Vilja, Pasanen, Annukka, Heikinheimo, Oskari, Karhu, Auli, Välimäki, Niko, Aaltonen, Lauri, Bützow, Ralf

“…Uterine leiomyoma (UL) is a common benign neoplasm which can sometimes be difficult to differentiate from the uterine inflammatory myofibroblastic tumor (IMT)…”
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Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness by Karvonen, Hanna, Arjama, Mariliina, Kaleva, Laura, Niininen, Wilhelmiina, Barker, Harlan, Koivisto-Korander, Riitta, Tapper, Johanna, Pakarinen, Päivi, Lassus, Heini, Loukovaara, Mikko, Bützow, Ralf, Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela

“…Glucocorticoids are routinely used in the clinic as anti-inflammatory and immunosuppressive agents as well as adjuvants during cancer treatment to mitigate the…”
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Comparison of 2SC, AKR1B10, and FH Antibodies as Potential Biomarkers for FH-deficient Uterine Leiomyomas by Ahvenainen, Terhi, Kaukomaa, Jaana, Kämpjärvi, Kati, Uimari, Outi, Ahtikoski, Anne, Mäkinen, Netta, Heikinheimo, Oskari, Aaltonen, Lauri A., Karhu, Auli, Bützow, Ralf, Vahteristo, Pia

“…Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumor predisposition syndrome caused by germline fumarate hydratase (FH) mutations and…”
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Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas by Välimäki, Niko, Jokinen, Vilja, Cajuso, Tatiana, Kuisma, Heli, Taira, Aurora, Dagnaud, Olivia, Ilves, Sini, Kaukomaa, Jaana, Pasanen, Annukka, Palin, Kimmo, Heikinheimo, Oskari, Bützow, Ralf, Aaltonen, Lauri A., Karhu, Auli

“…Uterine leiomyomas (ULs) are benign smooth muscle tumors that are common in premenopausal women. Somatic alterations in MED12, HMGA2, FH, genes encoding…”
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Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas by Heinonen, Hanna-Riikka, Pasanen, Annukka, Heikinheimo, Oskari, Tanskanen, Tomas, Palin, Kimmo, Tolvanen, Jaana, Vahteristo, Pia, Sjöberg, Jari, Pitkänen, Esa, Bützow, Ralf, Mäkinen, Netta, Aaltonen, Lauri A.

“…Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12) . These mutations have been associated with conventional…”
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Molecular Subtypes of Breast Cancers Detected in Mammography Screening and Outside of Screening by Sihto, Harri, Lundin, Johan, Lehtimäki, Tiina, Sarlomo-Rikala, Maarit, Bützow, Ralf, Holli, Kaija, Sailas, Liisa, Kataja, Vesa, Lundin, Mikael, Turpeenniemi-Hujanen, Taina, Isola, Jorma, Heikkilä, Päivi, Joensuu, Heikki

“…Purpose: The frequency and significance of gene expression profile-derived molecular subtypes of breast cancers found in mammography screening are unknown…”
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3′RNA and whole‐genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1 by Jokinen, Vilja, Mehine, Miika, Reinikka, Siiri, Khamaiseh, Sara, Ahvenainen, Terhi, Äyräväinen, Anna, Härkki, Päivi, Bützow, Ralf, Pasanen, Annukka, Vahteristo, Pia

“…Uterine leiomyomas, or fibroids, are very common smooth muscle tumors that arise from the myometrium. They can be divided into distinct molecular subtypes. We…”
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The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary by Jamieson, Stacey, Butzow, Ralf, Andersson, Noora, Alexiadis, Maria, Unkila-Kallio, Leila, Heikinheimo, Markku, Fuller, Peter J, Anttonen, Mikko

“…Granulosa cell tumors of the ovary represent ∼5% of malignant ovarian cancers. It has recently been reported that 95–97% of adult granulosa cell tumors carry a…”
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Identification of six new susceptibility loci for invasive epithelial ovarian cancer by Lee, Andrew, Pejovic, Tanja, Li, Qiyuan, Hazelett, Dennis, Miron, Alexander, Southey, Melissa, Terry, Mary Beth, Buys, Saundra S, Janavicius, Ramunas, Barrowdale, Daniel, Dennis, Joe, Papi, Laura, Konstantopoulou, Irene, Frost, Debra, Platte, Radka, Ellis, Steve, Sinilnikova, Olga M, Damiola, Francesca, Mazoyer, Sylvie, Stoppa-Lyonnet, Dominique, Piedmonte, Marion, O'Malley, David M, de la Hoya, Miguel, Aittomäki, Kristiina, Rookus, Matti A, Tihomirova, Laima, Hamann, Ute, Imyanitov, Evgeny N, Hogervorst, Frans B L, Diez, Orland, Blanco, Ignacio, Lubinski, Jan, Sukiennicki, Grzegorz, Barkardottir, Rosa B, Plante, Marie, Montagna, Marco, Tognazzo, Silvia, Teixeira, Manuel R, Pankratz, Vernon S, Wang, Xianshu, Vijai, Joseph, Aghajanian, Carol A, Berger, Andreas, Tea, Muy-Kheng, Rennert, Gad, Glendon, Gord, Kruse, Torben A, Thomassen, Mads, Zidan, Jamal, Einbeigi, Zakaria, Nussbaum, Robert L, Lester, Jenny, Lambrechts, Diether, Lambrechts, Sandrina, Dicks, Ed, Rossing, Mary Anne, Eilber, Ursula, Wilkens, Lynne R, Hillemanns, Peter, Antonenkova, Natalia, Leminen, Arto, Modugno, Francesmary, Ness, Roberta B, Matsuo, Keitaro, Hosono, Satoyo, Kjaer, Susanne Kruger, Hogdall, Estrid, Woo, Yin-Ling, Goode, Ellen L, Berchuck, Andrew, Iversen, Edwin S, Cramer, Daniel W, Terry, Kathryn L, Bandera, Elisa V, Orlow, Irene, Tangen, Ingvild L, Aben, Katja K H, Brooks-Wilson, Angela, Cybulski, Cezary, Lundvall, Lene, Baker, Helen, Eccles, Diana, Paul, James, Carty, Karen, McGuire, Valerie, Zheng, Wei, Gao, Yu-Tang, Rosen, Barry, Risch, Harvey A, Narod, Steven A, Monteiro, Alvaro N, Lin, Hui-Yi, Tsai, Ya-Yu, Ziogas, Argyrios, Anton-Culver, Hoda, Gentry-Maharaj, Aleksandra, Menon, Usha, Dansonka-Mieszkowska, Agnieszka, Easton, Douglas F, Chenevix-Trench, Georgia

“…Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian…”
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Altered glycosylation of glycodelin in endometrial carcinoma by Hautala, Laura C., Pang, Poh-Choo, Antonopoulos, Aristotelis, Pasanen, Annukka, Lee, Cheuk-Lun, Chiu, Philip C.N., Yeung, William S.B., Loukovaara, Mikko, Bützow, Ralf, Haslam, Stuart M., Dell, Anne, Koistinen, Hannu

“…Glycodelin is a major glycoprotein expressed in reproductive tissues, like secretory and decidualized endometrium. It has several reproduction related…”
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