Search Results - "BUTLER, Georgina S"

New intracellular activities of matrix metalloproteinases shine in the moonlight by Jobin, Parker G., Butler, Georgina S., Overall, Christopher M.

“…Adaption of a single protein to perform multiple independent functions facilitates functional plasticity of the proteome allowing a limited number of…”
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The Role of MMP8 in Cancer: A Systematic Review by Juurikka, Krista, Butler, Georgina S, Salo, Tuula, Nyberg, Pia, Åström, Pirjo

“…Matrix metalloproteinases (MMPs) have traditionally been considered as tumor promoting enzymes as they degrade extracellular matrix components, thus increasing…”
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Updated Biological Roles for Matrix Metalloproteinases and New “Intracellular” Substrates Revealed by Degradomics by Butler, Georgina S, Overall, Christopher M

“…Shotgun proteomics techniques are conceptually unbiased, but data interpretation and follow-up experiments are often constrained by dogma, established beliefs…”
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Multiplex N-terminome Analysis of MMP-2 and MMP-9 Substrate Degradomes by iTRAQ-TAILS Quantitative Proteomics by Prudova, Anna, auf dem Keller, Ulrich, Butler, Georgina S., Overall, Christopher M.

“…Proteolysis is a major protein posttranslational modification that, by altering protein structure, affects protein function and, by truncating the protein…”
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Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting by Butler, Georgina S, Overall, Christopher M

“…Proteomics techniques can be applied in drug target identification and validation, but data interpretation can be complicated by the identification of proteins…”
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Matrix metalloproteinase proteomics: substrates, targets, and therapy by Morrison, Charlotte J, Butler, Georgina S, Rodríguez, David, Overall, Christopher M

“…Proteomics encompasses powerful techniques termed ‘degradomics’ for unbiased high-throughput protease substrate discovery screens that have been applied to an…”
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A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity by Marchant, David J, Bellac, Caroline L, Moraes, Theo J, Wadsworth, Samuel J, Dufour, Antoine, Butler, Georgina S, Bilawchuk, Leanne M, Hendry, Reid G, Robertson, A Gordon, Cheung, Caroline T, Ng, Julie, Ang, Lisa, Luo, Zongshu, Heilbron, Karl, Norris, Michael J, Duan, Wenming, Bucyk, Taylor, Karpov, Andrei, Devel, Laurent, Georgiadis, Dimitris, Hegele, Richard G, Luo, Honglin, Granville, David J, Dive, Vincent, McManus, Bruce M, Overall, Christopher M

“…Matrix metalloproteinases (MMPs) normally act extracellularly. Now Marchant et al . report an unexpected nuclear activity for MMP-12 in virus-infected cells in…”
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Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase by Jobin, Parker G., Solis, Nestor, Machado, Yoan, Bell, Peter A., Kwon, Nam Hoon, Kim, Sunghoon, Overall, Christopher M., Butler, Georgina S.

“…Tryptophanyl-tRNA synthetase (WRS) is a cytosolic aminoacyl-tRNA synthetase essential for protein synthesis. WRS is also one of a growing number of…”
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Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage by Jobin, Parker G., Solis, Nestor, Machado, Yoan, Bell, Peter A., Rai, Simran K., Kwon, Nam Hoon, Kim, Sunghoon, Overall, Christopher M., Butler, Georgina S.

“…Tyrosyl-tRNA synthetase ligates tyrosine to its cognate tRNA in the cytoplasm, but it can also be secreted through a noncanonical pathway. We found that…”
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Macrophage Matrix Metalloproteinase-12 Dampens Inflammation and Neutrophil Influx in Arthritis by Bellac, Caroline L., Dufour, Antoine, Krisinger, Michael J., Loonchanta, Anantasak, Starr, Amanda E., auf dem Keller, Ulrich, Lange, Philipp F., Goebeler, Verena, Kappelhoff, Reinhild, Butler, Georgina S., Burtnick, Leslie D., Conway, Edward M., Roberts, Clive R., Overall, Christopher M.

“…Resolution of inflammation reduces pathological tissue destruction and restores tissue homeostasis. Here, we used a proteomic protease substrate…”
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Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding by Butler, Georgina S., Dean, Richard A., Tam, Eric M., Overall, Christopher M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors by Prudova, Anna, Gocheva, Vasilena, auf dem Keller, Ulrich, Eckhard, Ulrich, Olson, Oakley C., Akkari, Leila, Butler, Georgina S., Fortelny, Nikolaus, Lange, Philipp F., Mark, Jennifer C., Joyce, Johanna A., Overall, Christopher M.

“…Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ…”
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Identification of Candidate Angiogenic Inhibitors Processed by Matrix Metalloproteinase 2 (MMP-2) in Cell-Based Proteomic Screens: Disruption of Vascular Endothelial Growth Factor (VEGF)/Heparin Affin Regulatory Peptide (Pleiotrophin) and VEGF/Connective Tissue Growth Factor Angiogenic Inhibitory Complexes by MMP-2 Proteolysis by Dean, Richard A., Butler, Georgina S., Hamma-Kourbali, Yamina, Delbé, Jean, Brigstock, David R., Courty, José, Overall, Christopher M.

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Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2) by Butler, Georgina S., Connor, Andrea R., Sounni, Nor Eddine, Eckhard, Ulrich, Morrison, Charlotte J., Noël, Agnès, Overall, Christopher M.

“…Members of the CCN family of matricellular proteins are cytokines linking cells to the extracellular matrix. We report that CCN3 (Nov) and CCN5 (WISP2) are…”
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HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration by Overall, Christopher M, Power, Christopher, Zhang, Kunyan, McQuibban, G Angus, Silva, Claudia, Butler, Georgina S, Johnston, James B, Holden, Janet, Clark-Lewis, Ian

“…The mechanisms of neurodegeneration that result in human immunodeficiency virus (HIV) type 1 dementia have not yet been identified. Here, we report that…”
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Proteolytic Processing of SDF-1α Reveals a Change in Receptor Specificity Mediating HIV-Associated Neurodegeneration by Vergote, David, Butler, Georgina S., Ooms, Martine, Cox, Jennifer H., Silva, Claudia, Hollenberg, Morley D., Jhamandas, Jack H., Overall, Christopher M., Power, Christopher

“…Proteolytic cleavage of constitutively expressed proteins can generate peptides with novel bioactive properties. Matrix metalloproteinase (MMP)-2 cleaves the 4…”
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Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases by Panwar, Preety, Butler, Georgina S., Jamroz, Andrew, Azizi, Pouya, Overall, Christopher M., Brömme, Dieter

“…The natural aging process and various pathologies correlate with alterations in the composition and the structural and mechanical integrity of the connective…”
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Positional proteomics in the era of the human proteome project on the doorstep of precision medicine by Eckhard, Ulrich, Marino, Giada, Butler, Georgina S., Overall, Christopher M.

“…Proteolytic processing is a pervasive and irreversible post-translational modification that expands the protein universe by generating new proteoforms (protein…”
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Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14 by Eckhard, Ulrich, Huesgen, Pitter F., Schilling, Oliver, Bellac, Caroline L., Butler, Georgina S., Cox, Jennifer H., Dufour, Antoine, Goebeler, Verena, Kappelhoff, Reinhild, auf dem Keller, Ulrich, Klein, Theo, Lange, Philipp F., Marino, Giada, Morrison, Charlotte J., Prudova, Anna, Rodriguez, David, Starr, Amanda E., Wang, Yili, Overall, Christopher M.

“…The data described provide a comprehensive resource for the family-wide active site specificity portrayal of the human matrix metalloproteinase family. We used…”
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Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses by Eckhard, Ulrich, Huesgen, Pitter F., Schilling, Oliver, Bellac, Caroline L., Butler, Georgina S., Cox, Jennifer H., Dufour, Antoine, Goebeler, Verena, Kappelhoff, Reinhild, Keller, Ulrich auf dem, Klein, Theo, Lange, Philipp F., Marino, Giada, Morrison, Charlotte J., Prudova, Anna, Rodriguez, David, Starr, Amanda E., Wang, Yili, Overall, Christopher M.

“…Secreted and membrane tethered matrix metalloproteinases (MMPs) are key homeostatic proteases regulating the extracellular signaling and structural matrix…”
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