Search Results - "BUSIK, Julia V"

Lipid metabolism dysregulation in diabetic retinopathy by Busik, Julia V.

“…Lipid metabolic abnormalities have emerged as potential risk factors for the development and progression of diabetic complications, including diabetic…”
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Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators by BUSIK, Julia V, MOHR, Susanne, GRANT, Maria B

“…Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators Julia V. Busik 1 , Susanne Mohr 2 and Maria B…”
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A monophasic extraction strategy for the simultaneous lipidome analysis of polar and nonpolar retina lipids[S] by Lydic, Todd A., Busik, Julia V., Reid, Gavin E.

“…Lipid extraction using a monophasic chloroform/methanol/water mixture, coupled with functional group selective derivatization and direct infusion…”
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Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors by Agbaga, Martin-Paul, Merriman, Dana K., Brush, Richard S., Lydic, Todd A., Conley, Shannon M., Naash, Muna I., Jackson, Shelley, Woods, Amina S., Reid, Gavin E., Busik, Julia V., Anderson, Robert E.

“…Long-chain PUFAs (LC-PUFAs; C20–C22; e.g., DHA and arachidonic acid) are highly enriched in vertebrate retina, where they are elongated to very-long-chain…”
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Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition by Huang, Chao, Fisher, Kiera P, Hammer, Sandra S, Busik, Julia V

“…Several studies have suggested that there is a link between membrane attack complex (MAC) deposition in the retina and the progression of diabetic retinopathy…”
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2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis by El-Darzi, Nicole, Mast, Natalia, Hammer, Sandra S., Dorweiler, Tim F., Busik, Julia V., Pikuleva, Irina A.

“…CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to…”
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ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability by Kady, Nermin M, Liu, Xuwen, Lydic, Todd A, Syed, Meesum H, Navitskaya, Svetlana, Wang, Qi, Hammer, Sandra S, O'Reilly, Sandra, Huang, Chao, Seregin, Sergey S, Amalfitano, Andrea, Chiodo, Vince A, Boye, Sanford L, Hauswirth, William W, Antonetti, David A, Busik, Julia V

“…Tight junctions (TJs) involve close apposition of transmembrane proteins between cells. Although TJ proteins have been studied in detail, the role of lipids is…”
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Regulation of retinal inflammation by rhythmic expression of MiR-146a in diabetic retina by Wang, Qi, Bozack, Svetlana N, Yan, Yuanqing, Boulton, Michael E, Grant, Maria B, Busik, Julia V

“…Chronic inflammation and dysregulation of circadian rhythmicity are involved in the pathogenesis of diabetic retinopathy. MicroRNAs (miRNAs) can regulate…”
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Imbalances in Mobilization and Activation of Pro-Inflammatory and Vascular Reparative Bone Marrow-Derived Cells in Diabetic Retinopathy by Chakravarthy, Harshini, Beli, Eleni, Navitskaya, Svetlana, O'Reilly, Sandra, Wang, Qi, Kady, Nermin, Huang, Chao, Grant, Maria B, Busik, Julia V

“…Diabetic retinopathy is a sight-threatening complication of diabetes, affecting 65% of patients after 10 years of the disease. Diabetic metabolic insult leads…”
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Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy by Chakravarthy, Harshini, Navitskaya, Svetlana, O'Reilly, Sandra, Gallimore, Jacob, Mize, Hannah, Beli, Eleni, Wang, Qi, Kady, Nermin, Huang, Chao, Blanchard, Gary J., Grant, Maria B., Busik, Julia V.

“…The metabolic insults associated with diabetes lead to low‐grade chronic inflammation, retinal endothelial cell damage, and inadequate vascular repair. This is…”
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N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function by Tikhonenko, Maria, Lydic, Todd A, Opreanu, Madalina, Li Calzi, Sergio, Bozack, Svetlana, McSorley, Kelly M, Sochacki, Andrew L, Faber, Matthew S, Hazra, Sugata, Duclos, Shane, Guberski, Dennis, Reid, Gavin E, Grant, Maria B, Busik, Julia V

“…The vasodegenerative phase of diabetic retinopathy is characterized by not only retinal vascular degeneration but also inadequate vascular repair due to…”
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Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes by Levitsky, Yan, Hammer, Sandra S, Fisher, Kiera P, Huang, Chao, Gentles, Travan L, Pegouske, David J, Xi, Caimin, Lydic, Todd A, Busik, Julia V, Proshlyakov, Denis A

“…Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer (retinal pigment epithelium (RPE)) blood-retinal barriers (BRB) is…”
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Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina by Qi, Xiaoping, Mitter, Sayak K, Yan, Yuanqing, Busik, Julia V, Grant, Maria B, Boulton, Michael E

“…Retinal homeostasis is under both diurnal and circadian regulation. We sought to investigate the diurnal expression of autophagy proteins in normal rodent…”
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Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow by BHATWADEKAR, Ashay D, YUANQING YAN, BOULTON, Michael E, GRANT, Maria B, XIAOPING QI, THINSCHMIDT, Jeffrey S, NEU, Matthew B, LI CALZI, Sergio, SHAW, Lynn C, DOMINIGUEZ, James M, BUSIK, Julia V, LEE, Choogon

“…In this study, we assessed whether Per2 clock gene-mutant mice exhibit a vascular phenotype similar to diabetes. Per2 (B6.129-Per2(tm1Drw)/J) or wild-type…”
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Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy by Wang, Qi, Navitskaya, Svetlana, Chakravarthy, Harshini, Huang, Chao, Kady, Nermin, Lydic, Todd A., Chen, Y. Eugene, Yin, Ke-Jie, Powell, Folami Lamoke, Martin, Pamela M., Grant, Maria B., Busik, Julia V.

“…Activation of pro-inflammatory and pro-angiogenic pathways in the retina and the bone marrow contributes to pathogenesis of diabetic retinopathy. We identified…”
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Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors by Bennett, Lea D, Brush, Richard S, Chan, Michael, Lydic, Todd A, Reese, Kristen, Reid, Gavin E, Busik, Julia V, Elliott, Michael H, Anderson, Robert E

“…Autosomal dominant Stargardt-like macular dystrophy (STGD3) is a juvenile-onset disease that is caused by mutations in Elovl4 (elongation of very long fatty…”
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The role of cholesterol crystals and ocular crystal emboli in retinal pathology by Medawar, Nicholas G., Dorweiler, Tim F., Abela, George S., Busik, Julia V., Grant, Maria B.

“…Cholesterol crystals (CC) can be responsible for a range of clinical syndromes in the retina from asymptomatic plaques to retinal artery occlusion with…”
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Changes in the daily rhythm of lipid metabolism in the diabetic retina by Wang, Qi, Tikhonenko, Maria, Bozack, Svetlana N, Lydic, Todd A, Yan, Lily, Panchy, Nicholas L, McSorley, Kelly M, Faber, Matthew S, Yan, Yuanqing, Boulton, Michael E, Grant, Maria B, Busik, Julia V

“…Disruption of circadian regulation was recently shown to cause diabetes and metabolic disease. We have previously demonstrated that retinal lipid metabolism…”
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Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes by Yan, Yuanqing, Salazar, Tatiana E, Dominguez, 2nd, James M, Nguyen, Dung V, Li Calzi, Sergio, Bhatwadekar, Ashay D, Qi, Xiaoping, Busik, Julia V, Boulton, Michael E, Grant, Maria B

“…Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and…”
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The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor by Hammer, Sandra S., Beli, Eleni, Kady, Nermin, Wang, Qi, Wood, Kiana, Lydic, Todd A., Malek, Goldis, Saban, Daniel R., Wang, Xiaoxin X., Hazra, Sugata, Levi, Moshe, Busik, Julia V., Grant, Maria B.

“…Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite…”
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