Search Results - "BUSH, Ashley I"

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics by Belaidi, Abdel A., Bush, Ashley I.

“…Brain iron homeostasis is increasingly recognized as a potential target for the development of drug therapies for aging‐related disorders. Dysregulation of…”
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Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration by Masaldan, Shashank, Bush, Ashley I., Devos, David, Rolland, Anne Sophie, Moreau, Caroline

“…Perturbations in iron homeostasis and iron accumulation feature in several neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease…”
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Biological metals and metal-targeting compounds in major neurodegenerative diseases by Barnham, Kevin J, Bush, Ashley I

“…Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in age-related neurodegenerative disorders, Alzheimer's disease,…”
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Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease by Jakaria, Md, Belaidi, Abdel Ali, Bush, Ashley I., Ayton, Scott

“…Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While β‐amyloid plaque and…”
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Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases by Furtado, Denzil, Björnmalm, Mattias, Ayton, Scott, Bush, Ashley I., Kempe, Kristian, Caruso, Frank

“…Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largely due to the blood–brain…”
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Treating Alzheimer's disease by targeting iron by Nikseresht, Sara, Bush, Ashley I., Ayton, Scott

“…No disease modifying drugs have been approved for Alzheimer's disease despite recent major investments by industry and governments throughout the world. The…”
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Zinc in the physiology and pathology of the CNS by Sensi, Stefano L, Paoletti, Pierre, Bush, Ashley I, Sekler, Israel

“…Key Points The development of new imaging tools and transgenic animals has greatly improved our understanding of the physiological and pathophysiological role…”
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Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease by Lane, Darius J R, Metselaar, Billie, Greenough, Mark, Bush, Ashley I, Ayton, Scott J

“…Ferroptosis is an iron- and lipid peroxidation-dependent cell death modality and emerging evidence indicates that ferroptosis has great explanatory potential…”
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Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics by Duce, James A, Bush, Ashley I

“…The equilibrium of metal ions is critical for many physiological functions, particularly in the central nervous system, where metals are essential for…”
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Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol–Disulfide Exchange between Protein Thiols and Glutathione by Xiao, Zhiguang, La Fontaine, Sharon, Bush, Ashley I., Wedd, Anthony G.

“…The tripeptide glutathione (GSH) and its oxidized form glutathione disulfide (GSSG) constitute a key redox couple in cells. In particular, they partner protein…”
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Cerebrospinal fluid ceruloplasmin levels predict cognitive decline and brain atrophy in people with underlying β-amyloid pathology by Diouf, Ibrahima, Bush, Ashley I., Ayton, Scott

“…The mechanisms leading to neurodegeneration in Alzheimer's disease (AD) may involve oxidative stress and neuroinflammation. Ceruloplasmin (Cp) is a circulating…”
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Therapeutics for Alzheimer's Disease Based on the Metal Hypothesis by Bush, Ashley I., Tanzi, Rudolph E.

“…Alzheimer's disease is the most common form of dementia in the elderly, and it is characterized by elevated brain iron levels and accumulation of copper and…”
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The neurophysiology and pathology of brain zinc by Sensi, Stefano L, Paoletti, Pierre, Koh, Jae-Young, Aizenman, Elias, Bush, Ashley I, Hershfinkel, Michal

“…Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability…”
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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis by Masaldan, Shashank, Clatworthy, Sharnel A.S., Gamell, Cristina, Meggyesy, Peter M., Rigopoulos, Antonia-Tonia, Haupt, Sue, Haupt, Ygal, Denoyer, Delphine, Adlard, Paul A., Bush, Ashley I., Cater, Michael A.

“…Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death…”
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Copper in the brain and Alzheimer's disease by Hung, Ya Hui, Bush, Ashley I, Cherny, Robert Alan

“…Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The brain is particularly vulnerable to oxidative damage induced by unregulated…”
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CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease by Southon, Adam, Szostak, Kathryn, Acevedo, Karla M., Dent, Krista A., Volitakis, Irene, Belaidi, Abdel A., Barnham, Kevin J., Crouch, Peter J., Ayton, Scott, Donnelly, Paul S., Bush, Ashley I.

“…Background and Purpose Diacetyl‐bis(4‐methyl‐3‐thiosemicarbazonato)copperII (CuII(atsm)) ameliorates neurodegeneration and delays disease progression in mouse…”
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Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology by Diouf, Ibrahima, Fazlollahi, Amir, Bush, Ashley I., Ayton, Scott

“…β-Amyloid pathology is elevated in ~30% of cognitively normal people over 65, and is associated with accelerated neurodegeneration in the pre-clinical stages…”
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Selenium, selenoproteins and neurodegenerative diseases by Cardoso, Bárbara Rita, Roberts, Blaine R, Bush, Ashley I, Hare, Dominic J

“…It is unsurprising that our understanding of the role of selenium in neurological function is somewhat immature, considering its relatively recent discovery as…”
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Iron as a therapeutic target for Parkinson's disease by Moreau, Caroline, Duce, James A., Rascol, Olivier, Devedjian, Jean‐Christophe, Berg, Daniela, Dexter, David, Cabantchik, Z. Ioav, Bush, Ashley I., Devos, David

“…An urgent need for efficacious disease modifying therapies is required to slow downParkinson’s disease (PD) progression. Iron is required as a cofactor in…”
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Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease? by Adlard, Paul A, Parncutt, Jacqui M, Finkelstein, David I, Bush, Ashley I

“…Zinc transporter-3 (ZnT3) protein controls synaptic vesicular Zn(2+) levels, which is predicted to regulate normal cognitive function. Surprisingly, previous…”
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