Search Results - "BUSBY, W. F. JR"

Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay by Busby, Jr, W F, Stevens, E K, Kellenbach, E R, Cornelisse, J, Lugtenburg, J

“…Cyclopenta[cd]pyrene (CPP) was a potent tumorigen when tested over a 5-fold dose range in the newborn mouse assay. A 20-fold increase in lung tumor…”
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Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay by Busby, Jr, W F, Goldman, M E, Newberne, P M, Wogan, G N

“…A 24 week lung adenoma bioassay using newborn mice was employed to determine the tumorigenicity of fluoranthene, a common environmental polynuclear aromatic…”
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Comparative lung tumorigenicity of parent and mononitro-polynuclear aromatic hydrocarbons in the BLU:Ha newborn mouse assay by Busby, Jr, W F, Stevens, E K, Martin, C N, Chow, F L, Garner, R C

“…A BLU:Ha newborn mouse lung adenoma bioassay was employed to compare the tumorigenicity of selected mononitroarenes and unsubstituted parent compounds 6 months…”
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Carcinogenicity in rats of the nitrosated bile acid conjugates N-nitrosoglycocholic acid and N-nitrosotaurocholic acid by BUSBY, W. F. JR, SHUKER, D. E. G, CHARNLEY, G, NEWBERNE, P. M, TANNENBAUM, S. R, WOGAN, G. N

“…Two nitrosated bile acid conjugates, N-nitrosoglycocholic acid and N-nitrosotaurocholic acid, were examined for carcinogenicity in a 2-year study with male…”
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Seasonal and Spatial Variation of the Bacterial Mutagenicity of Fine Organic Aerosol in Southern California by Hannigan, Michael P., Cass, Glen R., Lafleur, Arthur L., Busby, William F., Thilly, William G.

“…The bacterial mutagenicity of a set of 1993 urban particulate air pollution samples is examined using the Salmonella typhimurium TM677 forward mutation assay…”
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Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro by J M Essigmann, R G Croy, A M Nadzan, W F Busby, Jr, V N Reinhold, G Büchi, G N Wogan

“…The covalent binding of the hepatocarcinogen aflatoxin B1 by rat liver microsomes to calf thymus DNA resulted in a binding level equal to one aflatoxin residue…”
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Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450 by BUSBY, W. F, ACKERMANN, J. M, CRESPI, C. L

“…The effects of methanol, ethanol, dimethyl sulfoxide (DMSO), and acetonitrile were studied in vitro on nine individual, cDNAexpressed cytochrome P-450…”
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Mutagenicity of the atmospheric transformation products 2-nitrofluoranthene and 2-nitrodibenzopyranone in Salmonella and human cell forward mutation assays by Busby Jr, William F, Smith, Henrietta, Crespi, Charles L, Penman, Bruce W, Lafleur, Arthur L

“…The mutagenicity of the atmospheric transformation products 2-nitrofluoranthene (2-NF) and 2-nitrodibenzopyranone (2-NDBP), as well as a related isomer…”
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Mutagenicity of cyclopenta-fused polynuclear aromatic hydrocarbons and a non-polar fraction from a fuel combustion sample in a Salmonella forward mutation assay without exogenous metabolic activation by Busby Jr, William F, Smith, Henrietta, Plummer, Elaine F, Lafleur, Arthur L, Mulder, Patrick P.J, Boere, Ben B, Cornelisse, Jan, Lugtenburg, Johan

“…A series of cyclopenta-fused polynuclear aromatic hydrocarbons (PAH) were tested for mutagenicity in a bacterial forward mutation assay based on resistance to…”
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Percutaneous Absorption and Tissue Distribution of [3H]Diacetoxyscirpenol (Anguidine) in Rats and Mice by Wang, Jia-Sheng, Busby, Jr, William F., Wogan, Gerald N.

“…Acute toxicity, absorption, excretion, and tissue distribution of topically administered diacetoxyscirpenol (DAS, anguidine) were studied in Fischer rats and…”
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6-Nitrochrysene is a potent tumorigen in newborn mice by Busby, Jr, W F, Garner, R C, Chow, F L, Martin, C N, Stevens, E K, Newberne, P M, Wogan, G N

“…A newborn mouse (BLU:Ha) lung adenoma bioassay demonstrated that 6-nitrochrysene was a highly potent tumorigen. It induced 100% incidence of lung tumors and a…”
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Lung tumorigenicity of benzene oxide, benzene dihydrodiols and benzene diolepoxides in the BLU:Ha newborn mouse assay by Busby, Jr, W F, Wang, J S, Stevens, E K, Padykula, R E, Aleksejczyk, R A, Berchtold, G A

“…Metabolic activation of benzene may occur by a pathway analogous to that accepted for polynuclear aromatic hydrocarbons (PAHs) involving ring epoxidation,…”
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Enhancement of methylbenzylnitrosamine-induced esophageal carcinogenesis in zinc-deficient rats: effects on incorporation of [3H]thymidine into DNA of esophageal epithelium and liver by Schrager, T F, Busby, Jr, W F, Goldman, M E, Newberne, P M

“…[3H]Thymidine incorporation was measured in esophageal epithelium and liver DNA of rats fed a control diet ad libitum, a zinc-deficient diet or a control diet,…”
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Commercial hickory-smoke flavouring is a human lymphoblast mutagen but does not induce lung adenomas in newborn mice by Braun, A G, Busby, Jr, W F, Jackman, J, Halpin, P A, Thilly, W G

“…Commercial aqueous wood-smoke flavouring induced significant increases in the 6-thioguanine resistance mutation frequency of TK6 human lymphoblasts at 0.1…”
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Excretion of radioactivity from rats and rabbits following cutaneous application of two 14C-labeled azo dyes by Aldrich, F D, Busby, Jr, W F, Fox, J G

“…A benzidine-derived azo dye, C.I. direct black 38 (DB38), and a p-phenylenediamine-derived dye, C.I. direct black 19 (DB19), labeled with carbon-14 in their…”
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Chemical and Toxicological Characterization of Residential Oil Burner Emissions: II. Mutagenic, Tumorigenic, and Potential Teratogenic Activity by Braun, Andrew G., Busby, William F., Liber, Howard L., Thilly, William G.

“…Extracts of effluents from a modern residential oil burner have been evaluated in several toxicological assay systems. Bacterial mutagens were detected in…”
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Mutagenicity of benzo[a]pyrene and dibenzopyrenes in the Salmonella typhimurium TM677 and the MCL-5 human cell forward mutation assays by Busby, William F., Smith, Henrietta, Crespi, Charles L., Penman, Bruce W.

“…The mutagenicity of beno[ a]pyrene (B[ a]P), dibenzo[ ae]pyrene (DB[ ae]P), dibenzo[ ah]pyrene (DB[ ah]P), dibenzo[ ai]pyrene (DB[ ai]P) and dibenzo[ al]pyrene…”
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Bioassay-Directed Chemical Analysis of Los Angeles Airborne Particulate Matter Using a Human Cell Mutagenicity Assay by Hannigan, Michael P, Cass, Glen R, Penman, Bruce W, Crespi, Charles L, Lafleur, Arthur L, Busby, William F, Thilly, William G, Simoneit, Bernd R. T

“…The human cell mutagenicity of Los Angeles airborne fine particulate matter is examined via bioassay-directed chemical analysis. A 1993 composite fine particle…”
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Human Lymphoblast Mutagens in Urban Airborne Particles by Durant, John L, Lafleur, Arthur L, Plummer, Elaine F, Taghizadeh, Koli, Busby, William F, Thilly, William G

“…While it is known that urban airborne particles typically contain trace levels of bacterial mutagens and rodent carcinogens, little work has been done to…”
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Effects of hydroxyurea and benzo(a)pyrene on DNA synthesis in the isolated perfused rat lung by Imamura, T, Busby, Jr, W F, Goldman, M E, Wogan, G N, Brunengraber, H

“…The authors have investigated the feasibility of utilizing a perfused rat lung model to: (1) determine whether DNA synthesis can be measured ex vivo by (…”
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