Search Results - "BURY, Marina"
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Transmembrane (TMEM) protein family members: Poorly characterized even if essential for the metastatic process
Published in Seminars in cancer biology (01-02-2020)“…The majority of cancer-associated deaths are related to secondary tumor formation. This multistep process involves the migration of cancer cells to…”
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NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor
Published in Cell reports (Cambridge) (05-11-2019)“…Constitutive nuclear factor κB (NF-κB) activation is a hallmark of colon tumor growth. Cyclin-dependent kinases (CDKs) are critical cell-cycle regulators, and…”
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Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway
Published in Nature cell biology (01-07-2018)“…Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a…”
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Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity
Published in International journal of oncology (01-08-2013)“…Ophiobolin A, a sesterterpenoid produced by plant pathogenic fungi, was purified from the culture extract of Drechslera gigantea and tested for its…”
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Fusicoccin A, a Phytotoxic Carbotricyclic Diterpene Glucoside of Fungal Origin, Reduces Proliferation and Invasion of Glioblastoma Cells by Targeting Multiple Tyrosine Kinases
Published in Translational oncology (01-04-2013)“…Abstract Glioblastoma multiforme (GBM) is a deadly cancer that possesses an intrinsic resistance to pro-apoptotic insults, such as conventional chemotherapy…”
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New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy
Published in Trends in cell biology (01-05-2021)“…Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the transition between different phases of the cell cycle. CDK/cyclin…”
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Abstract 2086: Role of the transcription factor NFE2L3 in TNFα signaling pathway in colorectal cancer
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Patients with inflammatory bowel disease have an increased risk of developing colorectal cancer (CRC), which is the third leading cause of cancer related…”
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Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite
Published in Proceedings of the National Academy of Sciences - PNAS (25-01-2022)“…Cells are continuously exposed to potentially dangerous compounds. Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases…”
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SUZ domain–containing proteins have multiple effects on nonsense-mediated decay target transcripts
Published in The Journal of biological chemistry (01-09-2023)“…Many transcripts are targeted by nonsense-mediated decay (NMD), leading to their degradation and the inhibition of their translation. We found that the protein…”
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Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines
Published in Biochemical journal (19-02-2019)“…Repair of a certain type of oxidative DNA damage leads to the release of phosphoglycolate, which is an inhibitor of triose phosphate isomerase and is predicted…”
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ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation
Published in Cellular and molecular life sciences : CMLS (01-12-2024)“…Hydroxylated fatty acids are important intermediates in lipid metabolism and signaling. Surprisingly, the metabolism of 4-hydroxy fatty acids remains largely…”
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Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment
Published in Oncogene (10-03-2022)“…We investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer. Our studies revealed that Nfe2l3 −/− mice exhibit…”
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Senescence Induced by UVB in Keratinocytes Impairs Amino Acids Balance
Published in Journal of investigative dermatology (01-04-2023)“…Skin is one of the most exposed organs to external stress. Namely, UV rays are the most harmful stress that could induce important damage leading to skin aging…”
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A protein mutated in Parkinson's disease prevents damage of metabolites and proteins caused by a glycolytic metabolite
Published in The FASEB journal (01-05-2022)“…The accumulation of cellular damage is suspected to contribute to aging and neurodegenerative diseases. Oxidative stress and environmental factors likely play…”
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N-(2-{3-[3,5-Bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): A Novel Anticancer Glycyrrhetinic Acid Derivative that Targets the Proteasome and Displays Anti-Kinase Activity
Published in Journal of medicinal chemistry (13-10-2011)“…18-β-Glycyrrhetinic acid (GA; 1) and many of its derivatives are cytotoxic in cancer cells. The current study aims to characterize the anticancer effects of 17…”
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Evaluation of the anticancer activities of two fungal polycyclic ethanones, alternethanoxins A and B, and two of their derivatives
Published in International journal of oncology (01-01-2011)“…Alternethanoxins A (1) and B (2) are fungal phytotoxins that are produced by Alternaria sonchi and have been recently characterized as new polycyclic…”
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In vitro anticancer activity, toxicity and structure–activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii
Published in Toxicology and applied pharmacology (01-07-2011)“…The in vitro anticancer activity and toxicity of phyllostictine A, a novel oxazatricycloalkenone recently isolated from a plant-pathogenic fungus (…”
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Fusicoccin A, a Phytotoxic Carbotricyclic Diterpene Glucoside of Fungal Origin, Reduces Proliferation and Invasion of Glioblastoma Cells by Targeting Multiple Tyrosine Kinases1
Published in Translational oncology (01-04-2013)“…Glioblastoma multiforme (GBM) is a deadly cancer that possesses an intrinsic resistance to pro-apoptotic insults, such as conventional chemotherapy and…”
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