Search Results - "BURROWS, Jon"

c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention by Christensen, James G., Burrows, Jon, Salgia, Ravi

“…Receptor tyrosine kinase (RTK) targeted agents such as trastuzumab, imatinib, bevacizumab, and gefitinib inhibitors have illustrated the utility of targeting…”
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Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH by Catenacci, Daniel V. T., Liao, Wei-Li, Zhao, Lei, Whitcomb, Emma, Henderson, Les, O’Day, Emily, Xu, Peng, Thyparambil, Sheeno, Krizman, David, Bengali, Kathleen, Uzzell, Jamar, Darfler, Marlene, Cecchi, Fabiola, Blackler, Adele, Bang, Yung-Jue, Hart, John, Xiao, Shu-Yuan, Lee, Sang Mee, Burrows, Jon, Hembrough, Todd

“…Background Trastuzumab has shown a survival benefit in cases of Her2-positive gastroesophageal cancer (GEC). Immunohistochemistry (IHC) and fluorescence in…”
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Chemical chaperones mediate increased secretion of mutant α1-antitrypsin (α1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in α1-AT deficiency by Burrows, Jon A. J., Willis, Lauren K., Perlmutter, David H.

“…In α1-AT deficiency, a misfolded but functionally active mutant α1-ATZ (α1-ATZ) molecule is retained in the endoplasmic reticulum of liver cells rather than…”
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Absolute quantitation of Met using mass spectrometry for clinical application: assay precision, stability, and correlation with MET gene amplification in FFPE tumor tissue by Catenacci, Daniel V T, Liao, Wei-Li, Thyparambil, Sheeno, Henderson, Les, Xu, Peng, Zhao, Lei, Rambo, Brittany, Hart, John, Xiao, Shu-Yuan, Bengali, Kathleen, Uzzell, Jamar, Darfler, Marlene, Krizman, David B, Cecchi, Fabiola, Bottaro, Donald P, Karrison, Theodore, Veenstra, Timothy D, Hembrough, Todd, Burrows, Jon

“…Overexpression of Met tyrosine kinase receptor is associated with poor prognosis. Overexpression, and particularly MET amplification, are predictive of…”
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Application of Selected Reaction Monitoring for Multiplex Quantification of Clinically Validated Biomarkers in Formalin-Fixed, Paraffin-Embedded Tumor Tissue by Hembrough, Todd, Thyparambil, Sheeno, Liao, Wei-Li, Darfler, Marlene M, Abdo, Joseph, Bengali, Kathleen M, Hewitt, Stephen M, Bender, Richard A, Krizman, David B, Burrows, Jon

“…One of the critical gaps in the clinical diagnostic space is the lack of quantitative proteomic methods for use on formalin-fixed, paraffin-embedded (FFPE)…”
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Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue by Hembrough, Todd, Thyparambil, Sheeno, Liao, Wei-Li, Darfler, Marlene M, Abdo, Joseph, Bengali, Kathleen M, Taylor, Paul, Tong, Jiefei, Lara-Guerra, Humberto, Waddell, Thomas K, Moran, Michael F, Tsao, Ming-Sound, Krizman, David B, Burrows, Jon

“…Analysis of key therapeutic targets such as epidermal growth factor receptor (EGFR) in clinical tissue samples is typically done by immunohistochemistry (IHC)…”
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Abstract 5537: Quantitative multiplexed SRM analysis of oncogenic receptors in FFPE colorectal carcinoma tissue by Hembrough, Todd, Thyparambil, Sheeno, Liao, Wei-Li, Darfler, Marlene, Krizman, David, Adams, Richard, Burrows, Jon

“…Multiple receptor tyrosine kinases are the target of either approved drugs (Her2, EGFR) or robust clinical development efforts (cMet, IGF1R, Her3, etc). In…”
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The Proteasome Participates in Degradation of Mutant α1-Antitrypsin Z in the Endoplasmic Reticulum of Hepatoma-derived Hepatocytes by Teckman, Jeffrey H., Burrows, Jon, Hidvegi, Tunde, Schmidt, Bela, Hale, Pamela D., Perlmutter, David H.

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High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy by Nuciforo, Paolo, Thyparambil, Sheeno, Aura, Claudia, Garrido-Castro, Ana, Vilaro, Marta, Peg, Vicente, Jimenez, José, Vicario, Rocio, Cecchi, Fabiola, Hoos, William, Burrows, Jon, Hembrough, Todd, Ferreres, Juan Carles, Perez-Garcia, José, Arribas, Joaquin, Cortes, Javier, Scaltriti, Maurizio

“…Current methods to determine HER2 (human epidermal growth factor receptor 2) status are affected by reproducibility issues and do not reliably predict benefit…”
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West is Best!; or, what we can learn from Bournemouth by Burrows, Jon

“…This article demonstrates that the film presentations of British public hall showmen in the 1900s were often more elaborate and oriented towards middle-class…”
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Abstract 3395: Clinical Survey of 19 actionable proteins in multiple indications using multiplex mass spectrometry by Cecchi, Fabiola, Blackler, Adele, Jordan, Heather, Darfler, Marlene, Hembrough, Todd, Stocum, Michael, Burrows, Jon

“…Many available oncology therapies are targeted to specific proteins, the most notable examples being therapies targeted to EGFR and Her2. For targeted…”
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Abstract 4255: Development and clinical validation of a quantitative mass spectrometric assay for immuno-oncology targets in FFPE samples by Thyparambil, Sheeno P., Cecchi, Fabiola, An, Eunkyung, Liao, Wei-Li, Burrows, Jon, Hembrough, Todd, Catenacci, Daniel

“…BackgroundImmune check point proteins play a pivotal role in immune evasion by the tumor. Recent trials involving inhibitors of the immune checkpoint protein…”
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Near broke, but no tramp: Billie Ritchie, Charlie Chaplin and 'that costume' by Burrows, Jon

“…This article revisits the various claims and counter-claims that have been made over the years as to whether the 1910s music hall comedian turned slapstick…”
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Proteomic analysis of primary and metastatic breast cancers and expression of the folate receptor as a potential drug target by Hembrough, Todd A., Cecchi, Fabiola, Blackler, Adele, Thyparambil, Sheeno P, Burrows, Jon, O'Shaughnessy, Joyce

“…Abstract only…”
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A selective small molecule inhibitor of c-Met kinase inhibits c-met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo by CHRISTENSEN, James G, SCHRECK, Randall, LIPSON, Kenneth E, RAMPHAL, John, DO, Steven, CUI, Jingrong J, CHERRINGTON, Julie M, MENDEL, Dirk B, BURROWS, Jon, KURUGANTI, Poonam, CHAN, Emily, PHUONG LE, CHEN, Jeffrey, XUEYAN WANG, RUSLIM, Lany, BLAKE, Robert

“…The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the development and progression of several human…”
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Abstract 3397: A novel clinical tool that provides quantitative and accurate measurement of Met protein by Cecchi, Fabiola, Liao, Wei-Li, Thyparambil, Sheeno, Darfler, Marlene, Krizman, David, Hembrough, Todd, Burrows, Jon, Bottaro, Don, Catenacci, Daniel V.T.

“…BACKGROUND: Overexpression of Met tyrosine kinase receptor is associated with poor prognosis. Overexpression, and particularly MET amplification, are…”
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Abstract 3398: Development of a mass spectrometry based antibody-drug conjugate biomarker panel by Blackler, Adele, Liao, Wei-Li, Thyparambil, Sheeno, An, Eunkyung, Cecchi, Fabiola, Darfler, Marlene, Hembrough, Todd, Burrows, Jon

“…Background: Antibody-Drug Conjugates (ADCs) are poised to become an extremely important class of therapeutics in oncology. By conjugating cytotoxic payloads to…”
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Abstract 566: ChemoPlex SRM assay predicts response to specific chemotherapeutic agents in NSCLC by An, Eunkyung, Kim, Tae-Jung, Monga, Manish, Bengali, Kathleen, Drilea, Alexi, Reilly, Joseph, Darfler, Marlene, Burrows, Jon, Hembrough, Todd

“…Current cancer treatment regimens rely on the use of chemotherapy agents that inhibit DNA replication and repair machinery. Several proteins are involved in…”
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Quantification of Anaplastic Lymphoma Kinase Protein Expression in Non-Small Cell Lung Cancer Tissues from Patients Treated with Crizotinib by Hembrough, Todd, Liao, Wei-Li, Hartley, Christopher P, Ma, Patrick C, Velcheti, Vamsidhar, Lanigan, Christopher, Thyparambil, Sheeno, An, Eunkyung, Monga, Manish, Krizman, David, Burrows, Jon, Tafe, Laura J

“…Crizotinib has antitumor activity in ALK (anaplastic lymphoma receptor tyrosine kinase)-rearranged non-small cell lung cancer (NSCLC). The current diagnostic…”
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Genomics, transcriptomics, and proteomics in the clinical setting: Integrating whole genome and RNA sequencing with quantitative proteomics to better inform clinical treatment selection by Rabizadeh, Shahrooz, Benz, Stephen Charles, Burrows, Jon, Hembrough, Todd A., Sanborn, John Z, Vaske, Charles Joseph, Soon-Shiong, Patrick

“…Abstract only…”
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