Search Results - "BURNHAM, W. Mcintyre"

Antiseizure effects of the cannabinoids in the amygdala‐kindling model by Fallah, Merrick S., Dlugosz, Lukasz, Scott, Brian W., Thompson, Miles D., Burnham, W. McIntyre

“…Objective Focal impaired awareness seizures (FIASs) are the most common seizure type in adults and are often refractory to medication. Management of FIASs is…”
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Development of propagated discharge and behavioral arrest in hippocampal and amygdala-kindled animals by Mohamed, Jabir, Scott, Brian W, David, Olivier, McIntyre Burnham, W.

“…•The Network Inhibition Hypothesis was tested using partially-kindled rats.•Afterdischarges propagated more quickly from the hippocampus than the amygdala.•The…”
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A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models by Mielnik, Catharine A., Sugamori, Kim S., Finlay, David B., Thorpe, Hayley H. A., Schapira, Matthieu, Sivananthan, Nirunthan, Li, Chun Kit, Lam, Vincent M., Harrington, Sean, Abdelrahman, Mostafa H., Trembleau, Laurent A., McIntyre Burnham, W., Khokhar, Jibran Y., Salahpour, Ali, Ramsey, Amy J., Glass, Michelle, Greig, Iain R., Ross, Ruth A.

“…Abstract The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs…”
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Pharmacogenetics of the G protein-coupled receptors by Thompson, Miles D, Cole, David E C, Capra, Valerie, Siminovitch, Katherine A, Rovati, G Enrico, Burnham, W McIntyre, Rana, Brinda K

“…Pharmacogenetics investigates the influence of genetic variants on physiological phenotypes related to drug response and disease, while pharmacogenomics takes…”
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Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia by Studzinski, Christa M., Christie, Lori-Ann, Araujo, Joseph A., Burnham, W. McIntyre, Head, Elizabeth, Cotman, Carl W., Milgram, Norton W.

“…Visuospatial learning and memory impairments are an early marker for age-related cognitive decline and Alzheimer’s disease. Similar to humans, aged dogs show…”
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Involvement of the neuronal phosphotyrosine signal adaptor N-Shc in kainic acid-induced epileptiform activity by Baba, Shiro, Onga, Kazuko, Kakizawa, Sho, Ohyama, Kyoji, Yasuda, Kunihiko, Otsubo, Hiroshi, Scott, Brian W., Burnham, W. McIntyre, Matsuo, Takayuki, Nagata, Izumi, Mori, Nozomu

“…BDNF-TrkB signaling is implicated in experimental seizures and epilepsy. However, the downstream signaling involved in the epileptiform activity caused by TrkB…”
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Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction by Abdelmalik, Peter A, Shannon, Patrick, Yiu, Adelaide, Liang, Philip, Adamchik, Yana, Weisspapir, Michael, Samoilova, Marina, McIntyre Burnham, W, Carlen, Peter L

“…Abstract Severe hypoglycemia constitutes a medical emergency, involving seizures, coma and death. We hypothesized that seizures, during limited substrate…”
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Dose‐dependent anticonvulsant effects of linoleic and α‐linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats by Taha, Ameer Y., Filo, Elvis, Ma, David W. L., McIntyre Burnham, W.

“…Summary Purpose:  Linoleic and α‐linolenic polyunsaturated fatty acids, derived from plant oils, have been reported to reduce neuronal excitability ex vivo and…”
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Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats by Taha, Ameer Y, Trepanier, Marc-Olivier, Coibanu, Flaviu A, Saxena, Anjali, Jeffrey, Melanie A, Taha, Nadeen M Y, Burnham, W McIntyre, Bazinet, Richard P

“…Brain concentrations of omega-3 docosahexaenoic acid (DHA, 22:6n-3) have been reported to positively correlate with seizure thresholds in rodent seizure…”
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The effects of right and left amygdala kindling on the female reproductive system in rats by Hum, Kathryn M., Megna, Sofia, McIntyre Burnham, W.

“…Summary Purpose:  Women with epilepsy often have comorbid reproductive dysfunction. Using the amygdala kindling model in rats, the present study examined the…”
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Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids by Taha, Ameer Y, Huot, Pedro S.P, Reza-López, Sandra, Prayitno, Nita R, Kang, Jing X, Burnham, W. McIntyre, Ma, David W.L

“…n-3 polyunsaturated fatty acids (PUFA), derived from marine oils, have been shown to protect against various neurological diseases. However, very little is…”
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The anticonvulsant effects of progesterone and its metabolites on amygdala-kindled seizures in male rats by Lonsdale, Deborah, Nylen, Kirk, McIntyre Burnham, W.

“…Progesterone is a neurosteroid that modulates neuronal excitability. The anticonvulsant effects of progesterone are largely mediated by the actions of its…”
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The Anticonvulsant Effects of Progesterone and 5α‐dihydroprogesterone on Amygdala‐kindled Seizures in Rats by Lonsdale and, Deborah, Burnham, W. McIntyre

“…Purpose: Progesterone has been shown to be anticonvulsant in several animal seizure models. The purpose of the present study was to investigate the…”
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The G protein-coupled receptors: Pharmacogenetics and Disease by Thompson, Miles D., Burnham, W. McIntyre, Cole, David E. C.

“…Genetic variation in G-protein coupled receptors (GPCRs) is associated with a wide spectrum of disease phenotypes and predispositions that are of special…”
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G protein-coupled receptors disrupted in human genetic disease by Thompson, Miles D, Percy, Maire E, McIntyre Burnham, W, Cole, David E C

“…Genetic variation in G protein-coupled receptors (GPCRs) results in the disruption of GPCR function in a wide variety of human genetic diseases. In vitro…”
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Lack of laterality in the effects of right and left amygdala kindling on weight gain in female rats by Hum, Kathryn M, Megna, Sofia, Burnham, W. McIntyre

“…Summary Purpose Women with epilepsy often suffer from weight gain. A similar phenomenon is seen in female rats that are kindled from the amygdala…”
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Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies by Wu, Yinhao Violet, Burnham, W. McIntyre

“…•Progesterone's anti-seizure effects are mediated by its metabolites: DHP and ALLO.•Progesterone, DHP and ALLO suppress non-absence seizures in…”
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Extrafocal threshold reductions in amygdala‐kindled rats by Scott, Brian W., Park, Harrison, Han, Hua, Wahidie, Ahsanullah, Burnham, W. McIntyre

“…Summary Purpose:  Racine’s classic study suggested that after discharge thresholds were reduced in the primary stimulation site (amygdala) of kindled rats, but…”
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A Comparison of the Ability of a 4:1 Ketogenic Diet and a 6.3:1 Ketogenic Diet to Elevate Seizure Thresholds in Adult and Young Rats by Nylen, Kirk, Likhodii, Sergei, Abdelmalik, Peter A., Clarke, Jasper, Burnham, W. McIntyre

“…Purpose: The pentylenetetrazol (PTZ) infusion test was used to compare seizure thresholds in adult and young rats fed either a 4:1 ketogenic diet (KD) or a…”
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The anti-seizure effects of IV 5α-dihydroprogesterone on amygdala-kindled seizures in rats by Wu, Yinhao Violet, Burnham, W. McIntyre

“…•5α-dihydroprogesterone, via the intravenous route, suppresses both generalized and focal seizures in a dose-dependent manner.•The intravenous route of…”
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