Search Results - "BURHENNE, J"

The NTCP‐inhibitor Myrcludex B: Effects on Bile Acid Disposition and Tenofovir Pharmacokinetics by Blank, A, Eidam, A, Haag, M, Hohmann, N, Burhenne, J, Schwab, M, Graaf, SFJ, Meyer, MR, Maurer, HH, Meier, K, Weiss, J, Bruckner, T, Alexandrov, A, Urban, S, Mikus, G, Haefeli, WE

“…Myrcludex B acts as a hepatitis B and D virus entry inhibitor blocking the sodium taurocholate cotransporting polypeptide (SLC10A1). We investigated the…”
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Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation by Rettig, I, Koeneke, E, Trippel, F, Mueller, W C, Burhenne, J, Kopp-Schneider, A, Fabian, J, Schober, A, Fernekorn, U, von Deimling, A, Deubzer, H E, Milde, T, Witt, O, Oehme, I

“…For differentiation-defective malignancies, compounds that modulate transcription, such as retinoic acid and histone deacetylase (HDAC) inhibitors, are of…”
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Determining the Time Course of CYP3A Inhibition by Potent Reversible and Irreversible CYP3A Inhibitors Using A Limited Sampling Strategy by Katzenmaier, S, Markert, C, Riedel, K-D, Burhenne, J, Haefeli, W E, Mikus, G

“…We established a new limited sampling strategy to assess CYP3A activity and evaluated the time course of reversible (voriconazole) and irreversible (ritonavir)…”
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A Nanogram Dose of the CYP3A Probe Substrate Midazolam to Evaluate Drug Interactions by Halama, B, Hohmann, N, Burhenne, J, Weiss, J, Mikus, G, Haefeli, W E

“…The objective of the study was to establish an in vivo method for assessing cytochrome P450 3A (CYP3A) activity using therapeutically inert nanogram doses of…”
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Long-Term Efavirenz Autoinduction and Its Effect on Plasma Exposure in HIV Patients by Ngaimisi, E, Mugusi, S, Minzi, O M, Sasi, P, Riedel, K‐D, Suda, A, Ueda, N, Janabi, M, Mugusi, F, Haefeli, W E, Burhenne, J, Aklillu, E

“…We investigated the influence of gender and pharmacogenetic variations on long‐term efavirenz autoinduction and disposition among patients with HIV in Tanzania…”
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Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling by Motorin, Yuri, Burhenne, Jürgen, Teimer, Roman, Koynov, Kaloian, Willnow, Sophie, Weinhold, Elmar, Helm, Mark

“…This work identifies the combination of enzymatic transfer and click labeling as an efficient method for the site-specific tagging of RNA molecules for…”
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High plasma efavirenz level and CYP2B66 are associated with efavirenz-based HAART-induced liver injury in the treatment of naïve HIV patients from Ethiopia: a prospective cohort study by Yimer, G, Amogne, W, Habtewold, A, Makonnen, E, Ueda, N, Suda, A, Worku, A, Haefeli, W E, Burhenne, J, Aderaye, G, Lindquist, L, Aklillu, E

“…The objective of this study was to assess the incidence, timing and identify pharmacogenetic, efavirenz (EFV) pharmacokinetic and biochemical predictors of…”
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Higher chlorzoxazone clearance in obese children compared with nonobese peers by Gade, C., Dalhoff, K., Petersen, T. S., Riis, T., Schmeltz, C., Chabanova, E., Christensen, H. R., Mikus, G., Burhenne, J., Holm, J. C., Holst, H.

“…Aims To test the in vivo activity of Cytochrome P450 (CYP) 2E1 in obese children vs. nonobese children, aged 11–18 years. Secondly, whether the activity of…”
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High plasma efavirenz level and CYP2B6 6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naive HIV patients from Ethiopia: a prospective cohort study by Yimer, G, Amogne, W, Habtewold, A, Makonnen, E, Ueda, N, Suda, A, Worku, A, Haefeli, WE, Burhenne, J, Aderaye, G

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Steady-state pharmacokinetics and metabolism of voriconazole in patients by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Riedel, Klaus-Dieter, Weiss, Johanna, Mikus, Gerd

“…Voriconazole exhibits non-linear pharmacokinetics in adults and is said to be mainly metabolized by CYP2C19 and CYP3A4 to voriconazole-N-oxide. The aim of this…”
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Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients by Habtewold, A, Amogne, W, Makonnen, E, Yimer, G, Nylén, H, Riedel, K-D, Aderaye, G, Bertilsson, L, Burhenne, J, Diczfalusy, U, Aklillu, E

“…We investigated the effects of pharmacogenetic variations and efavirenz pharmacokinetics on inter-individual differences in the extent of CYP3A induction by…”
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Effect of Rifampicin and CYP2B6 Genotype on Long‐Term Efavirenz Autoinduction and Plasma Exposure in HIV Patients With or Without Tuberculosis by Ngaimisi, E, Mugusi, S, Minzi, O, Sasi, P, Riedel, K‐D, Suda, A, Ueda, N, Janabi, M, Mugusi, F, Haefeli, W E, Bertilsson, L, Burhenne, J, Aklillu, E

“…We performed a prospective comparative study to examine, from a pharmacogenetics perspective, the effect of rifampicin (RIF) on long‐term efavirenz (EFV)…”
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No alteration of Cyp3A4 activity after major hepatectomy in the early postoperative period – A prospective before-after study by Jedamzik, J., Mühlbacher, J., Fitschek, F., Schwarz, C., Burhenne, J., Asenbaum, U., Kaczirek, K., Mikus, G.

“…The impact of major liver resection (LR) on the detoxifying function of the remaining liver tissue as represented by CYP3A activity has yet to be assessed…”
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Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment by Ngaimisi, E, Minzi, O, Mugusi, S, Sasi, P, Riedel, K-D, Suda, A, Ueda, N, Bakari, M, Janabi, M, Mugusi, F, Bertilsson, L, Burhenne, J, Aklillu, E, Diczfalusy, U

“…To assess the effect of the major efavirenz metabolizing enzyme (CYP2B6) genotype and the effects of rifampicin co-treatment on induction of CYP3A by…”
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Potential contribution of computer-aided detection to the sensitivity of screening mammography by Warren Burhenne, L J, Wood, S A, D'Orsi, C J, Feig, S A, Kopans, D B, O'Shaughnessy, K F, Sickles, E A, Tabar, L, Vyborny, C J, Castellino, R A

“…To determine the false-negative rate in screening mammography, the capability of computer-aided detection (CAD) to identify these missed lesions, and whether…”
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Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir by Mikus, Gerd, Schöwel, Verena, Drzewinska, Magdalena, Rengelshausen, Jens, Ding, Reinhard, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Thomsen, Torben, Haefeli, Walter E.

“…Objectives Cytochrome P450 (CYP) 2C19 and CYP3A4 are the major enzymes responsible for voriconazole elimination. Because the activity of CYP2C19 is under…”
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CYP2C9 Polymorphism is not a Major Determinant of Bosentan Exposure in Healthy Volunteers by Markert, C, Burhenne, J, Weiss, J, Mikus, G, Haefeli, WE

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Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients by Habtewold, Abiy, Amogne, Wondwossen, Makonnen, Eyasu, Yimer, Getnet, Riedel, Klaus-Dieter, Ueda, Nobuhisa, Worku, Alemayehu, Haefeli, Walter Emil, Lindquist, Lars, Aderaye, Getachew, Burhenne, Jürgen, Aklillu, Eleni

“…Objectives We investigated the long-term effect of efavirenz autoinduction on its plasma/peripheral blood mononuclear cell (PBMC) exposure and the CD4 count,…”
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Effect of Simultaneous Induction and Inhibition of CYP3A by St John's Wort and Ritonavir on CYP3A Activity by Hafner, V, Jäger, M, Matthée, A‐K, Ding, R, Burhenne, J, Haefeli, W E, Mikus, G

“…We aimed to assess the effect of coadministration and withdrawal of a potent cytochrome P450 3A (CYP3A) inhibitor (ritonavir) and a potent CYP3A inducer (St…”
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Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics by Rengelshausen, Jens, Banfield, Maria, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Thomsen, Torben, Walter‐Sack, Ingeborg, Haefeli, Walter E., Mikus, Gerd

“…Objectives Constituents of St John's wort (SJW) in vivo induce the cytochrome P450 (CYP) isozymes 3A4, 2C9, and 2C19 but in vitro were shown to inhibit them…”
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