Search Results - "BURGER, Karen"

Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis by Cook, Leah M., Frieling, Jeremy S., Nerlakanti, Niveditha, McGuire, Jeremy J., Stewart, Paul A., Burger, Karen L., Cleveland, John L., Lynch, Conor C.

“…Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells…”
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Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells by Burger, Karen L., Learman, Brian S., Boucherle, Amy K., Sirintrapun, S. Joseph, Isom, Scott, Díaz, Begoña, Courtneidge, Sara A., Seals, Darren F.

“…BACKGROUND The Src tyrosine kinase substrate and adaptor protein Tks5 had previously been implicated in the invasive phenotype of normal and transformed cell…”
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CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma by Burger, Karen L, Fernandez, Mario R, Meads, Mark B, Sudalagunta, Praneeth, Oliveira, Paula S, Renatino Canevarolo, Rafael, Alugubelli, Raghunandan Reddy, Tungsevik, Alexandre, De Avila, Gabe, Silva, Maria, Graeter, Allison I, Dai, Hongyue A, Vincelette, Nicole D, Prabhu, Antony, Magaletti, Dario, Yang, Chunying, Li, Weimin, Kulkarni, Amit, Hampton, Oliver, Koomen, John M, Roush, William R, Monastyrskyi, Andrii, Berglund, Anders E, Silva, Ariosto S, Cleveland, John L, Shain, Kenneth H

“…Multiple myeloma remains an incurable malignancy due to acquisition of intrinsic programs that drive therapy resistance. Here we report that casein kinase-1δ…”
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The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells by Maharaj, Kamira, Powers, John J., Achille, Alex, Mediavilla-Varela, Melanie, Gamal, Wael, Burger, Karen L., Fonseca, Renee, Jiang, Kun, Miskin, Hari P., Maryanski, Dave, Monastyrskyi, Andrii, Duckett, Derek R., Roush, William R., Cleveland, John L., Sahakian, Eva, Pinilla-Ibarz, Javier

“…The in-clinic phosphatidylinositol 3-kinase (PI3K) inhibitors idelalisib (CAL-101) and duvelisib (IPI-145) have demonstrated high rates of response and…”
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The podosome marker protein Tks5 regulates macrophage invasive behavior by Burger, Karen L., Davis, Amanda L., Isom, Scott, Mishra, Nilamadhab, Seals, Darren F.

“…Tks5 is a Src substrate and adaptor protein previously recognized for its regulation of cancer cell invasion through modulation of specialized adhesion…”
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A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma by Burger, Karen L, Meads, Mark B., Berglund, Anders, Oliveira, Paula S., Distler, Allison, Sudalagunta, Praneeth Reddy, Jacobson, Timothy, Teer, Jamie, Welsh, Eric A., Dai, Hongyue, Koomen, John M., Raghunandan Reddy, Alugubelli, De Avila, Gabriel, Tungesvik, Alexandre, Roush, William, Siqueira Silva, Ariosto, Shain, Kenneth H., Cleveland, John

“…Multiple Myeloma (MM) remains an incurable malignancy, despite the advent of several new therapeutic agents, including immunomodulatory drugs (IMiDs, e.g.,…”
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A CK1δ/CK1ε-to-Wnt/β-Catenin Circuit Is a Therapeutic Vulnerability in Primary and Drug Resistant Multiple Myeloma by Burger, Karen L., Meads, Mark B, Silva, Ariosto, Distler, Allison, Silva, Maria Coelho Siqueira, Jacobson, Timothy, Teer, Jamie K, Roush, William R., Shain, Kenneth H., Cleveland, John L.

“…Aberrant canonical Wnt/β-catenin signaling has long been known to play a role in cancer development and progression, where Wnt binding provokes nuclear…”
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A CK1δ/CK1ε-to-β-Catenin Circuit Is a Therapeutic Vulnerability for Primary and Drug Resistant Multiple Myeloma by Burger, Karen L, Meads, Mark B., Siqueira Silva, Ariosto, Oliveira, Paula, Nguyen, Tuan, Distler, Allison, Siqueira Silva, Maria Coelho, Jacobson, Timothy, Teer, Jamie, Dai, Hongyue, Roush, William, Cleveland, John, Shain, Kenneth H

“…Multiple Myeloma (MM) remains an incurable malignancy, despite the advent of several new therapeutic agents, including immunomodulatory drugs (IMiDs, e.g.,…”
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Fostering Resilience: Teaching Social-Emotional Skills by Gartrell, Dan, Cairone, Karen Burger

“…[...]Sylvia's parenting style became more consistent for Jake, lowering his stress levels and helping him respond to others. [...]more children wanted to play…”
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Identification of Target Pathways Induced By the Multiple Myeloma Tumor Microenvironment Using Activity-Based Protein Profiling and Ex Vivo Protein Kinase Inhibitor Screening by Meads, Mark B, Oliveira, Paula, Distler, Allison, Silva, Maria, Burger, Karen, Fang, Bin, Collins, Aunshka, Cleveland, John L., Koomen, John M., Silva, Ariosto, Rebatchouk, Dmitri, Shain, Kenneth H., Roush, William R.

“…Multiple myeloma (MM) is a heterogeneous plasma cell neoplasm that remains all but incurable despite recent advances in treatment. Indeed, nearly all patients…”
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Abstract 503: Investigating the role of Tks5 and invadopodia in prostate tumor progression by Burger, Karen L., Learman, Brian S., Boucherle, Amy K., Seals, Darren F.

“…Abstract Much of the morbidity and mortality in prostate cancer patients occurs strictly in response to metastatic disease. While ongoing efforts are examining…”
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Identification and Characterization of CTX-M-Producing Shigella Isolates in the United States by FOLSTER, Jason P, PECIC, Gary, KRUEGER, Amy, RICKERT, Regan, BURGER, Karen, CARATTOLI, Alessandra, WHICHARD, Jean M

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Src-Dependent Tks5 Phosphorylation Regulates Invadopodia-Associated Invasionin Prostate Cancer Cells by Burger, Karen L., Learman, Brian S., Boucherle, Amy K., Sirintrapun, S. Joseph, Isom, Scott, Díaz, Begoña, Courtneidge, Sara A., Seals, Darren F.

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Evaluation of a 4-META adhesive cement by Cooley, R L, Burger, K M, Chain, M C

“…This study investigated the shear bond strength of a new 4-META adhesive cement (C & B-Metabond) to dentin and Ni-Cr-Be alloy (Rexillium III). Fifteen human…”
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A Comparative Analysis of Intelligence Coordination After the 9/11 Attack and the Second Gulf War : Selected Case Studies by Burger, Karen Lizelle

“…The dissertation aims to examine the intelligence coordination mechanisms in the US and UK with a view to comparing them and identifying similarities and…”
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A description of the critical thinking skills observed in nursing students who use an interactive video program by Burger, Karen Lee

“…The purpose of this study was to determine if nursing students use critical thinking skills when engaged with an interactive video program and if they could…”
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Targeting, dosimetry, and radioimmunotherapy of B-cell lymphomas with iodine-131-labeled LL2 monoclonal antibody by Goldenberg, D M, Horowitz, J A, Sharkey, R M, Hall, T C, Murthy, S, Goldenberg, H, Lee, R E, Stein, R, Siegel, J A, Izon, D O

“…Sixteen patients with non-Hodgkin's lymphoma were infused with 6.2 to 58.2 mCi (0.2 to 3.9 mg) doses of radioactive iodine (131I)-labeled LL2 immunoglobulin G…”
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Clinical evaluation of tumor targeting with a high-affinity, anticarcinoembryonic-antigen-specific, murine monoclonal antibody, MN-14 by Sharkey, R M, Goldenberg, D M, Murthy, S, Pinsky, H, Vagg, R, Pawlyk, D, Siegel, J A, Wong, G Y, Gascon, P, Izon, D O

“…The authors previously reported that an anticarcinoembryonic antigen antibody against a carcinoembryonic antigen (CEA)-specific epitope is preferred for…”
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A description of the critical thinking skills observed in nursing students who use an interactive video program by Burger, Karen Lee

“…The purpose of this study was to determine if nursing students use critical thinking skills when engaged with an interactive video program and if they could…”
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Phase I clinical evaluation of a new murine monoclonal antibody (Mu-9) against colon-specific antigen-p for targeting gastrointestinal carcinomas by Sharkey, R M, Goldenberg, D M, Vagg, R, Pawlyk, D, Wong, G Y, Siegel, J A, Murthy, S, Levine, G M, Izon, D, Gascon, P

“…Colon-specific antigen-p is a tumor-associated antigen present in approximately 60% of colorectal cancers. Preclinical studies have shown that the murine…”
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