Search Results - "BURDZY, Artur"

Repair of the mutagenic DNA oxidation product, 5-formyluracil by Liu, Pingfang, Burdzy, Artur, Sowers, Lawrence C.

“…The oxidation of the thymine methyl group can generate 5-formyluracil (FoU). Template FoU residues are known to miscode, generating base substitution…”
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Characterization of the Substrate Specificity of a Human 5-Hydroxymethyluracil Glycosylase Activity by Baker, David, Liu, Pingfang, Burdzy, Artur, Sowers, Lawrence C

“…The oxidation of pyrimidine 5-methyl groups, derived from either thymine or 5-methylcytosine, can generate 5-hydroxymethyluracil (HmU) in DNA. An activity from…”
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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2) by Valinluck, Victoria, Tsai, Hsin-Hao, Rogstad, Daniel K., Burdzy, Artur, Bird, Adrian, Sowers, Lawrence C.

“…Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation, and is generally associated with reduced levels of transcription…”
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Chemical Decomposition of 5-Aza-2′-deoxycytidine (Decitabine): Kinetic Analyses and Identification of Products by NMR, HPLC, and Mass Spectrometry by Rogstad, Daniel K, Herring, Jason L, Theruvathu, Jacob A, Burdzy, Artur, Perry, Christopher C, Neidigh, Jonathan W, Sowers, Lawrence C

“…The nucleoside analogue 5-aza-2′-deoxycytidine (Decitabine, DAC) is one of several drugs in clinical use that inhibit DNA methyltransferases, leading to a…”
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Impact of Sugar Pucker on Base Pair and Mispair Stability by Williams, Adides A, Darwanto, Agus, Theruvathu, Jacob A, Burdzy, Artur, Neidigh, Jonathan W, Sowers, Lawrence C

“…The selection of nucleoside triphosphates by a polymerase is controlled by several energetic and structural features, including base pairing geometry as well…”
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Characterization of synthetic oligonucleotides containing biologically important modified bases by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry by Cui, Zhengfang, Theruvathu, Jacob A., Farrel, Alvin, Burdzy, Artur, Sowers, Lawrence C.

“…Oligonucleotides containing modified bases are commonly used for biochemical and biophysical studies to assess the impact of specific types of chemical damage…”
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5-Halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2) by Valinluck, Victoria, Liu, Pingfang, Kang, Joseph I., Burdzy, Artur, Sowers, Lawrence C.

“…Perturbations in cytosine methylation signals are observed in the majority of human tumors; however, it is as yet unknown how methylation patterns become…”
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Substrate Recognition by a Family of Uracil-DNA Glycosylases:  UNG, MUG, and TDG by Liu, Pingfang, Burdzy, Artur, Sowers, Lawrence C

“…In response to continuous hydrolytic and oxidative DNA damage, cells of all organisms have a complex network of repair systems that recognize, remove, and…”
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Characterization of synthetic oligonucleotides containing biologically important modified bases by MALDI-TOF mass spectrometry by Cui, Zhengfang, Theruvathu, Jacob A., Farrel, Alvin, Burdzy, Artur, Sowers, Lawrence C.

“…Oligonucleotides containing modified bases are commonly used for biochemical and biophysical studies to assess the impact of specific types of structural…”
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5-Formyluracil-Induced Perturbations of DNA Function by Rogstad, Daniel K, Heo, Jiyoung, Vaidehi, Nagarajan, Goddard, William A, Burdzy, Artur, Sowers, Lawrence C

“…Oxidation of the thymine methyl group can generate 5-formyluracil (FoU), which is known to be both mutagenic and chemically unstable in DNA. Synthetic…”
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Measurement of the Incorporation and Repair of Exogenous 5-Hydroxymethyl-2′-deoxyuridine in Human Cells in Culture Using Gas Chromatography-Negative Chemical Ionization-Mass Spectrometry by Rogstad, Daniel K, Darwanto, Agus, Herring, Jason L, Rogstad, Katherine Noyes, Burdzy, Artur, Hadley, Scott R, Neidigh, Jonathan W, Sowers, Lawrence C

“…The DNA of all organisms is constantly damaged by oxidation. Among the array of damage products is 5-hydroxymethyluracil, derived from oxidation of the thymine…”
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Synthesis of stable‐isotope enriched 5‐methylpyrimidines and their use as probes of base reactivity in DNA by Burdzy, Artur, Noyes, Katherine T., Valinluck, Victoria, Sowers, Lawrence C.

“…A specific and efficient method is presented for the conversion of 2′‐deoxyuridine to thymidine via formation and reduction of the intermediate 5‐hydroxymethyl…”
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Synthesis and Characterization of Oligonucleotides Containing 5-Chlorocytosine by Kang, Joseph I, Burdzy, Artur, Liu, Pingfang, Sowers, Lawrence C

“…Recent studies have shown that reactive chlorine species, derived from myeloperoxidase-mediated inflammation responses, can modify DNA bases, generating…”
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Endogenous DNA Lesions Can Inhibit the Binding of the AP-1 (c-Jun) Transcription Factor by Rogstad, Daniel K, Liu, Pingfang, Burdzy, Artur, Lin, Susan S, Sowers, Lawrence C

“…The repair of DNA damage, caused by both endogenous and exogenous sources, is necessary to remove lesions that either miscode or block DNA or RNA polymerases…”
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Influence of Local Duplex Stability and N 6-Methyladenine on Uracil Recognition by Mismatch-Specific Uracil-DNA Glycosylase (Mug) by Valinluck, Victoria, Liu, Pingfang, Burdzy, Artur, Ryu, Junichi, Sowers, Lawrence C

“…To maintain genomic integrity, DNA repair enzymes continually remove damaged bases and lesions resulting from endogenous and exogenous processes. These repair…”
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Influence of Local Duplex Stability and N6-Methyladenine on Uracil Recognition by Mismatch-Specific Uracil-DNA Glycosylase (Mug) by VALINLUCK, Victoria, LIU, Pingfang, BURDZY, Artur, RYU, Junichi, SOWERS, Lawrence C.

“…To maintain genomic integrity, DNA repair enzymes continually remove damaged bases and lesions resulting from endogenous and exogenous processes. These repair…”
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DNA ligases ensure fidelity by interrogating minor groove contacts by Liu, Pingfang, Burdzy, Artur, Sowers, Lawrence C.

“…DNA ligases, found in both prokaryotes and eukaryotes, covalently link the 3′-hydroxyl and 5′-phosphate ends of duplex DNA segments. This reaction represents a…”
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Acid promoted transformations of fluorescent luminarosine and its 2'-modified analogues by Burdzy, A, Skalski, B, Paszyc, S, Popenda, M, Adamiak, R W

“…The susceptibility of highly fluorescent luminarine nucleosides to acid promoted anomerization reactions has been studied in order to select a derivative with…”
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