Search Results - "BURCHARD, Esteban G"

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies by Rahmani, Elior, Zaitlen, Noah, Baran, Yael, Eng, Celeste, Hu, Donglei, Galanter, Joshua, Oh, Sam, Burchard, Esteban G, Eskin, Eleazar, Zou, James, Halperin, Eran

“…Principal component analysis on a subset of differentially methylated regions in a mixture of cell types is the basis of ReFACTor, a program to account for…”
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Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled by Oh, Sam S, Galanter, Joshua, Thakur, Neeta, Pino-Yanes, Maria, Barcelo, Nicolas E, White, Marquitta J, de Bruin, Danielle M, Greenblatt, Ruth M, Bibbins-Domingo, Kirsten, Wu, Alan H B, Borrell, Luisa N, Gunter, Chris, Powe, Neil R, Burchard, Esteban G

“…Esteban Gonzalez Burchard and colleagues explore how making medical research more diverse would aid not only social justice but scientific quality and clinical…”
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Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence by Williams, L. Keoki, MD, MPH, Peterson, Edward L., PhD, Wells, Karen, BS, Ahmedani, Brian K., PhD, Kumar, Rajesh, MD, MS, Burchard, Esteban G., MD, MPH, Chowdhry, Vimal K., PhD, Favro, David, BS, Lanfear, David E., MD, MS, Pladevall, Manel, MD, MS

“…Background Asthma is an inflammatory condition often punctuated by episodic symptomatic worsening, and accordingly, patients with asthma might have waxing and…”
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Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations by Everman, Jamie L., Sajuthi, Satria, Saef, Benjamin, Rios, Cydney, Stoner, Ari M., Numata, Mari, Hu, Donglei, Eng, Celeste, Oh, Sam, Rodriguez-Santana, Jose, Vladar, Eszter K., Voelker, Dennis R., Burchard, Esteban G., Seibold, Max A.

“…Research in transformed immortalized cell lines indicates the cadherin-related family member 3 (CDHR3) protein serves as a receptor for human rhinovirus…”
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The landscape of genomic imprinting across diverse adult human tissues by Baran, Yael, Subramaniam, Meena, Biton, Anne, Tukiainen, Taru, Tsang, Emily K, Rivas, Manuel A, Pirinen, Matti, Gutierrez-Arcelus, Maria, Smith, Kevin S, Kukurba, Kim R, Zhang, Rui, Eng, Celeste, Torgerson, Dara G, Urbanek, Cydney, Li, Jin Billy, Rodriguez-Santana, Jose R, Burchard, Esteban G, Seibold, Max A, MacArthur, Daniel G, Montgomery, Stephen B, Zaitlen, Noah A, Lappalainen, Tuuli

“…Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we…”
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Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease by Poole, Alex, MS, Urbanek, Cydney, BS, Eng, Celeste, BS, Schageman, Jeoffrey, BS, Jacobson, Sean, MS, O'Connor, Brian P., PhD, Galanter, Joshua M., MD, Gignoux, Christopher R., PhD, Roth, Lindsey A., MA, Kumar, Rajesh, MD, Lutz, Sharon, PhD, Liu, Andrew H., MD, Fingerlin, Tasha E., PhD, Setterquist, Robert A., PhD, Burchard, Esteban G., MD, Rodriguez-Santana, Jose, MD, Seibold, Max A., PhD

“…Background Bronchial airway expression profiling has identified inflammatory subphenotypes of asthma, but the invasiveness of this technique has limited its…”
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Early-Life Air Pollution and Asthma Risk in Minority Children: The GALA II and SAGE II Studies by NISHIMURA, Katherine K, GALANTER, Joshua M, BRIGINO-BUENAVENTURA, Emerita, DAVIS, Adam, LENOIR, Michael A, MEADE, Kelley, RODRIGUEZ-CINTRON, William, AVILA, Pedro C, BORRELL, Luisa N, BIBBINS-DOMINGO, Kirsten, RODRIGUEZ-SANTANA, Jose R, SEN, Saunak, ROTH, Lindsey A, LURMANN, Fred, BALMES, John R, BURCHARD, Esteban G, OH, Sam S, THAKUR, Neeta, NGUYEN, Elizabeth A, THYNE, Shannon, FARBER, Harold J, SEREBRISKY, Denise, KUMAR, Rajesh

“…Air pollution is a known asthma trigger and has been associated with short-term asthma symptoms, airway inflammation, decreased lung function, and reduced…”
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American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report by Woodruff, Prescott G, van den Berge, Maarten, Boucher, Richard C, Brightling, Christopher, Burchard, Esteban G, Christenson, Stephanie A, Han, MeiLan K, Holtzman, Michael J, Kraft, Monica, Lynch, David A, Martinez, Fernando D, Reddel, Helen K, Sin, Don D, Washko, George R, Wenzel, Sally E, Punturieri, Antonello, Freemer, Michelle M, Wise, Robert A

“…Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic obstructive lung diseases with an associated high burden of disease…”
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Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures by Galanter, Joshua M, Gignoux, Christopher R, Oh, Sam S, Torgerson, Dara, Pino-Yanes, Maria, Thakur, Neeta, Eng, Celeste, Hu, Donglei, Huntsman, Scott, Farber, Harold J, Avila, Pedro C, Brigino-Buenaventura, Emerita, LeNoir, Michael A, Meade, Kelly, Serebrisky, Denise, Rodríguez-Cintrón, William, Kumar, Rajesh, Rodríguez-Santana, Jose R, Seibold, Max A, Borrell, Luisa N, Burchard, Esteban G, Zaitlen, Noah

“…Populations are often divided categorically into distinct racial/ethnic groups based on social rather than biological constructs. Genetic ancestry has been…”
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action by Shu, Yan, Sheardown, Steven A, Brown, Chaline, Owen, Ryan P, Zhang, Shuzhong, Castro, Richard A, Ianculescu, Alexandra G, Yue, Lin, Lo, Joan C, Burchard, Esteban G, Brett, Claire M, Giacomini, Kathleen M

“…Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic…”
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Childhood asthma exacerbations and the Arg16 β2 -receptor polymorphism: A meta-analysis stratified by treatment by Turner, Steve, MD, Francis, Ben, PhD, Vijverberg, Susanne, PhD, Pino-Yanes, Maria, PhD, Maitland-van der Zee, Anke H., PhD, Basu, Kaninika, MD, Bignell, Lauren, MBBS, Mukhopadhyay, Somnath, MD, Tavendale, Roger, PhD, Palmer, Colin, PhD, Hawcutt, Daniel, PhD, Pirmohamed, Munir, PhD, Burchard, Esteban G., MD, MPH, Lipworth, Brian, MD

“…Background The Gly-to-Arg substitution at the 16 position (rs1042713) in the β2 -adrenoceptor gene (ADRB2) is associated with enhanced downregulation and…”
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Genome-Wide Analysis Reveals Mucociliary Remodeling of the Nasal Airway Epithelium Induced by Urban PM2.5 by Montgomery, Michael T, Sajuthi, Satria P, Cho, Seung-Hyun, Everman, Jamie L, Rios, Cydney L, Goldfarbmuren, Katherine C, Jackson, Nathan D, Saef, Benjamin, Cromie, Meghan, Eng, Celeste, Medina, Vivian, Elhawary, Jennifer R, Oh, Sam S, Rodriguez-Santana, Jose, Vladar, Eszter K, Burchard, Esteban G, Seibold, Max A

“…Montgomery et al discuss their genome-wide analysis of the nasal airway epithelium induced by urban particulate matter 2.5 (PM2.5). PM2.5 exposure is…”
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On the cross-population generalizability of gene expression prediction models by Keys, Kevin L, Mak, Angel C Y, White, Marquitta J, Eckalbar, Walter L, Dahl, Andrew W, Mefford, Joel, Mikhaylova, Anna V, Contreras, María G, Elhawary, Jennifer R, Eng, Celeste, Hu, Donglei, Huntsman, Scott, Oh, Sam S, Salazar, Sandra, Lenoir, Michael A, Ye, Jimmie C, Thornton, Timothy A, Zaitlen, Noah, Burchard, Esteban G, Gignoux, Christopher R

“…The genetic control of gene expression is a core component of human physiology. For the past several years, transcriptome-wide association studies have…”
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Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome by Wesolowska-Andersen, Agata, Everman, Jamie L, Davidson, Rebecca, Rios, Cydney, Herrin, Rachelle, Eng, Celeste, Janssen, William J, Liu, Andrew H, Oh, Sam S, Kumar, Rajesh, Fingerlin, Tasha E, Rodriguez-Santana, Jose, Burchard, Esteban G, Seibold, Max A

“…Respiratory illness caused by viral infection is associated with the development and exacerbation of childhood asthma. Little is known about the effects of…”
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ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia by HENG XU, CHENG CHENG, ENG, Celeste, DEAN, Michael, ANTILLON, Frederico, WINICK, Naomi J, MARTIN, Paul L, WILLMAN, Cheryl L, CAMITTA, Bruce M, REAMAN, Gregory H, CARROLL, William L, LOH, Mignon, DEVIDAS, Meenakshi, EVANS, William E, PUI, Ching-Hon, HUNGER, Stephen P, RELLING, Mary V, YANG, Jun J, DEQING PEI, YIPING FAN, WENJIAN YANG, NEALE, Geoff, SCHEET, Paul, BURCHARD, Esteban G, TORGERSON, Dara G

“…Recent genome-wide screens have identified genetic variations in ARID5B associated with susceptibility to childhood acute lymphoblastic leukemia (ALL). We…”
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The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity by Chan, Pamela Y., Silva, Eugenio A. Carrera, De Kouchkovsky, Dimitri, Joannas, Leonel D., Hao, Liming, Hu, Donglei, Huntsman, Scott, Eng, Celeste, Licona-Limón, Paula, Weinstein, Jason S., Herbert, De'Broski R., Craft, Joseph E., Flavell, Richard A., Repetto, Silvia, Correale, Jorge, Burchard, Esteban G., Torgerson, Dara G., Ghosh, Sourav, Rothlin, Carla V.

“…Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also…”
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Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population by Beecham, Ashley H, Amezcua, Lilyana, Chinea, Angel, Manrique, Clara P, Gomez, Lissette, Martinez, Andrea, Beecham, Gary W, Patsopoulos, Nikolaos A, Chitnis, Tanuja, Weiner, Howard L, De Jager, Philip L, Burchard, Esteban G, Lund, Brett T, Fitzgerald, Kathryn C, Calabresi, Peter A, Delgado, Silvia R, Oksenberg, Jorge R, McCauley, Jacob L

“…The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across…”
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Genetic ancestry influences asthma susceptibility and lung function among Latinos by Pino-Yanes, Maria, PhD, Thakur, Neeta, MD, MPH, Gignoux, Christopher R., PhD, Galanter, Joshua M., MD, MAS, Roth, Lindsey A., MA, Eng, Celeste, BS, Nishimura, Katherine K., MPH, Oh, Sam S., PhD, Vora, Hita, MS, Huntsman, Scott, MS, Nguyen, Elizabeth A., BS, Hu, Donglei, PhD, Drake, Katherine A., PhD, Conti, David V., PhD, Moreno-Estrada, Andres, MD, PhD, Sandoval, Karla, PhD, Winkler, Cheryl A., PhD, Borrell, Luisa N., DDS, PhD, Lurmann, Fred, MS, Islam, Talat S., MD, Davis, Adam, MA, MPH, Farber, Harold J., MD, MSPH, Meade, Kelley, MD, Avila, Pedro C., MD, Serebrisky, Denise, MD, Bibbins-Domingo, Kirsten, MD, PhD, Lenoir, Michael A., MD, Ford, Jean G., MD, Brigino-Buenaventura, Emerita, MD, Rodriguez-Cintron, William, MD, Thyne, Shannon M., MD, Sen, Saunak, PhD, Rodriguez-Santana, Jose R., MD, Bustamante, Carlos D., PhD, Williams, L. Keoki, MD, PhD, Gilliland, Frank D., MD, PhD, Gauderman, W. James, PhD, Kumar, Rajesh, MD, MSPH, Torgerson, Dara G., PhD, Burchard, Esteban G., MD, MPH

“…Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest…”
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PCA-correlated SNPs for structure identification in worldwide human populations by Paschou, Peristera, Ziv, Elad, Burchard, Esteban G, Choudhry, Shweta, Rodriguez-Cintron, William, Mahoney, Michael W, Drineas, Petros

“…Existing methods to ascertain small sets of markers for the identification of human population structure require prior knowledge of individual ancestry. Based…”
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Childhood Obesity and Asthma Control in the GALA II and SAGE II Studies by BORRELL, Luisa N, NGUYEN, Elizabeth A, LENOIR, Michael A, LURMANN, Fred, MEADE, Kelley, SEREBRISKY, Denise, RODRIGUEZ-CINTRON, William, KUMAR, Rajesh, RODRIGUEZ-SANTANA, Jose R, THYNE, Shannon M, BURCHARD, Esteban G, ROTH, Lindsey A, OH, Sam S, TCHEUREKDJIAN, Haig, SEN, Saunak, DAVIS, Adam, FARBER, Harold J, AVILA, Pedro C, BRIGINO-BUENAVENTURA, Emerita

“…Obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse asthma control. However, most prior…”
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