Search Results - "BURCH, L. H"

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy by PARR, C. E, SULLIVAN, D. M, PARADISO, A. M, LAZAROWSKI, E. R, BURCH, L. H, OLSEN, J. C, ERB, L, WEISMAN, G. A, BOUCHER, R. C, TURNER, J. T

“…The Cl- secretory pathway that is defective in cystic fibrosis (CF) can be bypassed by an alternative pathway for Cl- transport that is activated by…”
Get full text

A Novel Mutation in the Cystic Fibrosis Gene in Patients with Pulmonary Disease but Normal Sweat Chloride Concentrations by Highsmith, W. Edward, Burch, Lauranell H, Zhou, Zhaoqing, Olsen, John C, Boat, Thomas E, Spock, Alexander, Gorvoy, Jack D, Quittell, Lynne, Friedman, Kenneth J, Silverman, Lawrence M, Boucher, Richard C, Knowles, Michael R

“…Cystic fibrosis is an autosomal recessive genetic disorder that reflects mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, 1 –…”
Get full text

Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airways by Burch, L H, Talbot, C R, Knowles, M R, Canessa, C M, Rossier, B C, Boucher, R C

“…The availability of the newly cloned subunits (alpha, beta, gamma) of the epithelial Na+ channel (ENaC) permits molecular studies of the pathogenesis of the…”
Get full text

A CFTR mutation (D1152H) in a family with mild lung disease and normal sweat chlorides by Highsmith, Jr, W E, Friedman, K J, Burch, L H, Spock, A, Silverman, L M, Boucher, R C, Knowles, M R

Get full text

Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways by Picher, Maryse, Burch, Lauranell H, Hirsh, Andrew J, Spychala, Josef, Boucher, Richard C

“…In human airways, extracellular adenosine regulates epithelial functions supporting mucociliary clearance, an important airway defense mechanism against…”
Get full text

Spontaneous Mutations in Recombinant Inbred Mice: Mutant Toll-like Receptor 4 (Tlr4) in BXD29 Mice by Cook, Donald N, Whitehead, Gregory S, Burch, Lauranell H, Berman, Katherine G, Kapadia, Zareen, Wohlford-Lenane, Christine, Schwartz, David A

“…Recombinant inbred (RI) mice are frequently used to identify QTL that underlie differences in measurable phenotypes between two inbred strains of mice. Here we…”
Get full text

The Bacteriophage T4 Rapid-Lysis Genes and Their Mutational Proclivities by BURCH, Lauranell H, LEILEI ZHANG, CHAO, Frank G, HONG XU, DRAKE, John W

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression by Zhang, Xiaodong, Gainetdinov, Raul R., Beaulieu, Jean-Martin, Sotnikova, Tatyana D., Burch, Lauranell H., Williams, Redford B., Schwartz, David A., Krishnan, K.Ranga R., Caron, Marc G.

“…Dysregulation of central serotonin neurotransmission has been widely suspected as an important contributor to major depression. Here, we identify a (G1463A)…”
Get full text

Clinical and Pathologic Features of Familial Interstitial Pneumonia by Steele, Mark P, Speer, Marcy C, Loyd, James E, Brown, Kevin K, Herron, Aretha, Slifer, Susan H, Burch, Lauranell H, Wahidi, Momen M, Phillips, John A., III, Sporn, Thomas A, McAdams, H. Page, Schwarz, Marvin I, Schwartz, David A

“…Several lines of evidence suggest that genetic factors and environmental exposures play a role in the development of pulmonary fibrosis. We evaluated families…”
Get full text

The Role of Innate Immunity in Acute Allograft Rejection after Lung Transplantation by Palmer, Scott M, Burch, Lauranell H, Davis, R. Duane, Herczyk, Walter F, Howell, David N, Reinsmoen, Nancy L, Schwartz, David A

“…Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflammatory responses independent of adaptive immunity, it remains…”
Get full text

Innate Immunity Influences Long-term Outcomes after Human Lung Transplant by Palmer, Scott M, Burch, Lauranell H, Trindade, Anil J, Davis, R. Duane, Herczyk, Walter F, Reinsmoen, Nancy L, Schwartz, David A

“…Lung transplantation is characterized by very high rates of acute and chronic allograft rejection. We hypothesize that activation of innate immunity augments…”
Get full text

Neutrophil elastase induces mucus cell metaplasia in mouse lung by Voynow, Judith A, Fischer, Bernard M, Malarkey, David E, Burch, Lauranell H, Wong, Teresa, Longphre, Malinda, Ho, Samuel B, Foster, W Michael

“…Goblet cell hyperplasia in the superficial airway epithelia is a signature pathological feature of chronic bronchitis and cystic fibrosis. In these chronic…”
Get more information

Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis by Picher, Maryse, Burch, Lauranell H, Boucher, Richard C

“…Extracellular nucleotides are among the most potent mediators of mucociliary clearance (MCC) in human lungs. However, clinical trials revealed that aerosolized…”
Get full text

In Vitro Production of Tumor Necrosis Factor-Alpha by Human Monocytes Stimulated with Lipopolysaccharide is Positively Correlated with Increased Blood Monocytes After Exposure to a Swine Barn by Willson, P. J., Khozani, T. Talaei, Juurlink, B. H. J., Senthilselvan, A., Rennie, D. C., Gerdts, V., Gawaziuk, J., Schneberger, D., Burch, Lauranell H., Dosman, J. A.

“…Recently there has been interest in the air quality in and around intensive livestock production facilities, such as modern swine production barns, where…”
Get full text

Toll-like receptors and allograft rejection by Goldstein, Daniel R, Tesar, Bethany M

Get full text

Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation by Palmer, Scott M, Burch, Lauranell H, Mir, Saad, Smith, Stephen R, Kuo, Paul C, Herczyk, Walter F, Reinsmoen, Nancy L, Schwartz, David A

“…:  Background:  Although innate immunity is crucial to host defense against pathogens, the extent to which innate immune mechanisms participate in the…”
Get full text

Identification of a splice site mutation (2789 +5 G > A) associated with small amounts of normal CFTR mRNA and mild cystic fibrosis by Highsmith, Jr, W E, Burch, L H, Zhou, Z, Olsen, J C, Strong, T V, Smith, T, Friedman, K J, Silverman, L M, Boucher, R C, Collins, F S, Knowles, M R

“…A splicing mutation was identified at the +5 position of the splice donor site of exon 14b of CFTR in CF patients in a consanguineous family that is remarkable…”
Get full text

Cloning and expression of a human P(2U) nucleotide receptor, a target for cystic fibrosis pharmacotherapy by Parr, C Edward, Sullivan, Daniel M, Paradiso, Anthony M, Burch, Lauranell H

“…The sequence and functional expression of a cDNA cloned from human airway epithelial cells that encodes a protein with properties of a P2U nucleotide receptor,…”
Get full text

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy by Parr, C E, Sullivan, D M, Paradiso, A M, Lazarowski, E R, Burch, L H, Olsen, J C, Erb, L, Weisman, G A, Boucher, R C, Turner, J T

Get full text

Response to Correspondence: Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression by Zhang, Xiaodong, Gainetdinov, Raul R., Beaulieu, Jean-Martin, Sotnikova, Tatyana D., Burch, Lauranell H., Williams, Redford B., Schwartz, David A., Krishnan, K. Ranga R., Caron, Marc G.

“…Interestingly, 5 of the 9 subjects carrying the G1463A polymorphism were treated with electroconvulsive therapy (ECT), while only 16 subjects in this cohort of…”
Get full text