Search Results - "BUNKOWSKI, Stephanie"

Toll-Like Receptor Stimulation Enhances Phagocytosis and Intracellular Killing of Nonencapsulated and Encapsulated Streptococcus pneumoniae by Murine Microglia by Ribes, Sandra, Ebert, Sandra, Regen, Tommy, Agarwal, Amit, Tauber, Simone C, Czesnik, Dirk, Spreer, Annette, Bunkowski, Stephanie, Eiffert, Helmut, Hanisch, Uwe-Karsten, Hammerschmidt, Sven, Nau, Roland

“…Toll-like receptors (TLRs) are crucial pattern recognition receptors in innate immunity that are expressed in microglia, the resident macrophages of the brain…”
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Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists by Diesselberg, Catharina, Ribes, Sandra, Seele, Jana, Kaufmann, Annika, Redlich, Sandra, Bunkowski, Stephanie, Hanisch, Uwe-Karsten, Michel, Uwe, Nau, Roland, Schütze, Sandra

“…Bacterial meningitis is associated with high mortality and long-term neurological sequelae. Increasing the phagocytic activity of microglia could improve the…”
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The inflammatory response and neuronal injury in Streptococcus suis meningitis by Seele, Jana, Tauber, Simone C, Bunkowski, Stephanie, Baums, Christoph G, Valentin-Weigand, Peter, de Buhr, Nicole, Beineke, Andreas, Iliev, Asparouh I, Brück, Wolfgang, Nau, Roland

“…Many of the currently used models of bacterial meningitis have limitations due to direct inoculation of pathogens into the cerebrospinal fluid or brain and a…”
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Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage by Wippel, Carolin, Maurer, Jana, Förtsch, Christina, Hupp, Sabrina, Bohl, Alexandra, Ma, Jiangtao, Mitchell, Timothy J, Bunkowski, Stephanie, Brück, Wolfgang, Nau, Roland, Iliev, Asparouh I

“…Streptococcus pneumoniae (pneumococcal) meningitis is a common bacterial infection of the brain. The cholesterol-dependent cytolysin pneumolysin represents a…”
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Age does not influence the disease course in a mouse model of Streptococcus pneumoniae serotype 3 meningitis by Manig, Anja, Ribes, Sandra, Diesselberg, Catharina, Bunkowski, Stephanie, Nau, Roland, Schütze, Sandra

“…In order to elucidate the causes for the increased mortality of aged patients with bacterial central nervous system (CNS) infections, we compared the course of…”
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Increased mortality and spatial memory deficits in TNF-α-deficient mice in ceftriaxone-treated experimental pneumococcal meningitis by Gerber, Joachim, Böttcher, Tobias, Hahn, Michael, Siemer, Alexander, Bunkowski, Stephanie, Nau, Roland

“…Tumor necrosis factor-α (TNF-α) is critically involved in inflammation and may participate in hippocampal injury in bacterial meningitis. In a mouse model of…”
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Enriched environment fails to increase meningitis-induced neurogenesis and spatial memory in a mouse model of pneumococcal meningitis by Tauber, Simone C., Bunkowski, Stephanie, Ebert, Sandra, Schulz, Daniela, Kellert, Benedikt, Nau, Roland, Gerber, Joachim

“…An increase in adult neurogenesis was observed after exposure to enriched environment (EE) and during reconvalescence from experimental pneumococcal…”
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Rifampin Followed by Ceftriaxone for Experimental Meningitis Decreases Lipoteichoic Acid Concentrations in Cerebrospinal Fluid and Reduces Neuronal Damage in Comparison to Ceftriaxone Alone by GERBER, Joachim, POHL, Karin, SANDER, Valeska, BUNKOWSKI, Stephanie, NAU, Roland

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Interferon-gamma impairs phagocytosis of Escherichia coli by primary murine peritoneal macrophages stimulated with LPS and differentially modulates proinflammatory cytokine release by Schütze, Sandra, Kaufmann, Annika, Bunkowski, Stephanie, Ribes, Sandra, Nau, Roland

“…•IFN-γ reduces the phagocytosis of E. coli by LPS-stimulated peritoneal macrophages.•IFN-γ differentially modulates macrophage release of the TNF-α, IL-6, and…”
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Cisterno-lumbar gradient of complement fractions in geriatric patients with suspected normal pressure hydrocephalus by Seele, Jana, Kirschfink, Michael, Djukic, Marija, Lange, Peter, Gossner, Johannes, Bunkowski, Stephanie, Wiltfang, Jens, Nau, Roland

“…The complement system is a functional link between the innate and adaptive immune system and present in all compartments of the body. The composition of the…”
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Neural Injury and Repair in a Novel Neonatal Mouse Model of Listeria Monocytogenes Meningoencephalitis by Seele, Jana, Ballüer, Melissa, Tauber, Simone C, Bunkowski, Stephanie, Schulz, Katja, Stadelmann, Christine, Beineke, Andreas, Pägelow, Dennis, Fulde, Marcus, Nau, Roland

“…Abstract To improve the therapy of neonatal central nervous system infections, well-characterized animal models are urgently needed. The present study analyzes…”
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Identification of macrophage populations expressing tumor necrosis factor-α mRNA in acute multiple sclerosis by BITSCH, A, DA COSTA, C, BUNKOWSKI, S, WEBER, F, RIECKMANN, P, BRÜCK, W

“…Macrophages are involved in central nervous system (CNS) demyelination in multiple sclerosis (MS) and other demyelinating diseases. Macrophages seen in MS…”
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Small cisterno-lumbar gradient of phosphorylated Tau protein in geriatric patients with suspected normal pressure hydrocephalus by Djukic, Marija, Spreer, Annette, Lange, Peter, Bunkowski, Stephanie, Wiltfang, Jens, Nau, Roland

“…The composition of the cerebrospinal fluid (CSF) is not homogeneous, and concentrations of proteins from different origins diverge among ventricular, cisternal…”
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Intracerebral Infection with E. coli Impairs Spatial Learning and Induces Necrosis of Hippocampal Neurons in the Tg2576 Mouse Model of Alzheimer’s Disease by Schütze, Sandra, Döpke, Anika, Kellert, Benedikt, Seele, Jana, Ballüer, Melissa, Bunkowski, Stephanie, Kreutzfeldt, Mario, Brück, Wolfgang, Nau, Roland

“…Background: In patients with Alzheimer’s disease (AD), bacterial infections are often associated with a cognitive decline. Animal models of genuine acute…”
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The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells by Ribes, Sandra, Adam, Nina, Ebert, Sandra, Regen, Tommy, Bunkowski, Stephanie, Hanisch, Uwe-Karsten, Nau, Roland

“…Stimulation of murine primary microglia with Toll-like receptor (TLR) agonists enhances their ability to phagocytose and kill bacteria. Here we show that the…”
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Additive microglia-mediated neuronal injury caused by amyloid-β and bacterial TLR agonists in murine neuron-microglia co-cultures quantified by an automated image analysis using cognition network technology by Schütze, Sandra, Loleit, Tobias, Zeretzke, Moritz, Bunkowski, Stephanie, Brück, Wolfgang, Ribes, Sandra, Nau, Roland

“…Activated microglia is considered to be involved in the progression of Alzheimer's disease (AD). We investigated the effect of amyloid-β(1-40) (Aβ(40) and…”
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Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions by Schütze, Sandra, Ribes, Sandra, Kaufmann, Annika, Manig, Anja, Scheffel, Jörg, Redlich, Sandra, Bunkowski, Stephanie, Hanisch, Uwe-Karsten, Brück, Wolfgang, Nau, Roland

“…Incidence and mortality of bacterial meningitis are strongly increased in aged compared to younger adults demanding new strategies to improve prevention and…”
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Increased neurogenesis after hypoxic-ischemic encephalopathy in humans is age related by Mattiesen, Wulf-Rainer C., Tauber, Simone C., Gerber, Joachim, Bunkowski, Stephanie, Brück, Wolfgang, Nau, Roland

“…The leading cause of morbidity and mortality after successful resuscitation is hypoxic-ischemic encephalopathy (HIE), which results in neuronal loss within the…”
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Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair by Tauber, Simone C., Eiffert, Helmut, Kellner, Silvia, Lugert, Raimond, Bunkowski, Stephanie, Schütze, Sandra, Perske, Christina, Brück, Wolfgang, Nau, Roland

“…Aims The present study aimed at examining neuronal injury and repair in post mortem brain sections of humans who died from fungal central nervous system…”
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Long-Term Intrathecal Infusion of Outer Surface Protein C From Borrelia burgdorferi Causes Axonal Damage by Tauber, Simone C, Ribes, Sandra, Ebert, Sandra, Heinz, Torsten, Fingerle, Volker, Bunkowski, Stephanie, Kugelstadt, Dominik, Spreer, Annette, Jahn, Olaf, Eiffert, Helmut, Nau, Roland

“…Lyme neuroborreliosis (LNB) is the most frequent tick-borne infectious disease of the central nervous system. In acute LNB and the rare chronic state of…”
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