Search Results - "BUNIK, Victoria I"

A challenging interplay between basic research, technologies and medical education to provide therapies based on disease mechanisms by Bunik, Victoria I

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Editorial: Experts' opinion in medicine 2022 by Bunik, Victoria I.

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Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation by Bunik, Victoria I, Fernie, Alisdair R

“…Mechanism-based inhibitors and both forward and reverse genetics have proved to be essential tools in revealing roles for specific enzymatic processes in…”
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Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport by Aleshin, Vasily A, Kaehne, Thilo, Maslova, Maria V, Graf, Anastasia V, Bunik, Victoria I

“…Transketolase (TKT) is an essential thiamine diphosphate (ThDP)-dependent enzyme of the non-oxidative branch of the pentose phosphate pathway, with the…”
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Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex by Mkrtchyan, Garik V., Üçal, Muammer, Müllebner, Andrea, Dumitrescu, Sergiu, Kames, Martina, Moldzio, Rudolf, Molcanyi, Marek, Schaefer, Samuel, Weidinger, Adelheid, Schaefer, Ute, Hescheler, Juergen, Duvigneau, Johanna Catharina, Redl, Heinz, Bunik, Victoria I., Kozlov, Andrey V.

“…Based on the fact that traumatic brain injury is associated with mitochondrial dysfunction we aimed at localization of mitochondrial defect and attempted to…”
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Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase by Aleshin, Vasily A., Bunik, Victoria I., Bruch, Eduardo M., Bellinzoni, Marco

“…Glutamate dehydrogenase (GDH) plays a key role in the metabolism of glutamate, an important compound at a cross-road of carbon and nitrogen metabolism and a…”
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Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic Regulators in the Rat Brain by Aleshin, Vasily A, Graf, Anastasia V, Artiukhov, Artem V, Ksenofontov, Alexander L, Zavileyskiy, Lev G, Maslova, Maria V, Bunik, Victoria I

“…Epilepsy is characterized by recurrent seizures due to a perturbed balance between glutamate and GABA neurotransmission. Our goal is to reveal the molecular…”
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Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293 by Aleshin, Vasily A, Artiukhov, Artem V, Kaehne, Thilo, Graf, Anastasia V, Bunik, Victoria I

“…Coupling glycolysis and mitochondrial tricarboxylic acid cycle, pyruvate dehydrogenase (PDH) complex (PDHC) is highly responsive to cellular demands through…”
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Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain by Artiukhov, Artem V., Aleshin, Vasily A., Karlina, Irina S., Kazantsev, Alexey V., Sibiryakina, Daria A., Ksenofontov, Alexander L., Lukashev, Nikolay V., Graf, Anastasia V., Bunik, Victoria I.

“…Mitochondrial pyruvate dehydrogenase complex (PDHC) is essential for brain glucose and neurotransmitter metabolism, which is dysregulated in many pathologies…”
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Structure-function relationships in the 2-oxo acid dehydrogenase family: Substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins by Bunik, Victoria I., Degtyarev, Dmitry

“…Structural relationship within the family of the thiamine diphosphate‐dependent 2‐oxo acid dehydrogenases was analyzed by combining different methods of…”
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Editorial: Women in science - translational medicine 2021 by Bunik, Victoria I., Habak, Claudine

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Predictive markers for efficiency of the amino-acid deprivation therapies in cancer by Pokrovsky, Vadim S., Abo Qoura, Louay, Morozova, Elena, Bunik, Victoria I.

“…Amino acid deprivation therapy (AADT) is a promising strategy for developing novel anticancer treatments, based on variations in metabolism of healthy and…”
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Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age by Graf, Anastasia V, Maslova, Maria V, Artiukhov, Artem V, Ksenofontov, Alexander L, Aleshin, Vasily A, Bunik, Victoria I

“…Hypoxia is damaging to the fetus, but the developmental impact may vary, with underlying molecular mechanisms unclear. We demonstrate the dependence of…”
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The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy by Zavileyskiy, Lev G., Aleshin, Vasily A., Kaehne, Thilo, Karlina, Irina S., Artiukhov, Artem V., Maslova, Maria V., Graf, Anastasia V., Bunik, Victoria I.

“…Abnormal energy expenditure during seizures and metabolic regulation through post-translational protein acylation suggest acylation as a therapeutic target in…”
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Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action by Bunik, Victoria I, Aleshin, Vasily A, Zhou, Xiaoshan, Tabakov, Vyacheslav Yu, Karlsson, Anna

“…Genetic up-regulation of mitochondrial 2-oxoglutarate dehydrogenase is known to increase reactive oxygen species, being detrimental for cancer cells. Thiamine…”
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Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate by Aleshin, Vasily A, Zhou, Xiaoshan, Krishnan, Shuba, Karlsson, Anna, Bunik, Victoria I

“…Thiamine (vitamin B1) is often deficient in oncopatients, particularly those undergoing chemotherapy. However, interaction between the thiamine deficiency and…”
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Inhibition of 2-Oxoglutarate Dehydrogenase in Potato Tuber Suggests the Enzyme Is Limiting for Respiration and Confirms Its Importance in Nitrogen Assimilation by Araújo, Wagner L., Nunes-Nesi, Adriano, Trenkamp, Sandra, Bunik, Victoria I., Fernie, Alisdair R.

“…The 2-oxoglutarate dehydrogenase complex constitutes a mitochondrially localized tricarboxylic acid cycle multienzyme system responsible for the conversion of…”
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Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death by Weidinger, Adelheid, Milivojev, Nadja, Hosmann, Arthur, Duvigneau, J. Catharina, Szabo, Csaba, Törö, Gabor, Rauter, Laurin, Vaglio-Garro, Annette, Mkrtchyan, Garik V., Trofimova, Lidia, Sharipov, Rinat R., Surin, Alexander M., Krasilnikova, Irina A., Pinelis, Vsevolod G., Tretter, Laszlo, Moldzio, Rudolf, Bayır, Hülya, Kagan, Valerian E., Bunik, Victoria I., Kozlov, Andrey V.

“…Brain injury is accompanied by neuroinflammation, accumulation of extracellular glutamate and mitochondrial dysfunction, all of which cause neuronal death. The…”
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Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model by Aleshin, Vasily A., Graf, Anastasia V., Artiukhov, Artem V., Boyko, Alexandra I., Ksenofontov, Alexander L., Maslova, Maria V., Nogués, Isabel, di Salvo, Martino L., Bunik, Victoria I.

“…The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing…”
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Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation by Artiukhov, Artem V, Graf, Anastasia V, Kazantsev, Alexey V, Boyko, Alexandra I, Aleshin, Vasily A, Ksenofontov, Alexander L, Bunik, Victoria I

“…Specific inhibitors of mitochondrial 2-oxoglutarate dehydrogenase (OGDH) are administered to animals to model the downregulation of the enzyme as observed in…”
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