Search Results - "BUNCH, Roderick T"

Acute Molecular Markers of Rodent Hepatic Carcinogenesis Identified by Transcription Profiling by Kramer, Jeffrey A, Curtiss, Sandra W, Kolaja, Kyle L, Alden, Carl L, Blomme, Eric A. G, Curtiss, William C, Davila, Julio C, Jackson, Carmen J, Bunch, Roderick T

“…Currently, the only way to identify nongenotoxic hepatocarcinogens is through long-term repeat dose studies such as the 2 year rodent carcinogenicity assay…”
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MicroRNA as biomarkers of mitochondrial toxicity by Baumgart, Bethany R., Gray, Katherine L., Woicke, Jochen, Bunch, Roderick T., Sanderson, Thomas P., Van Vleet, Terry R.

“…Mitochondrial toxicity can be difficult to detect as most cells can tolerate reduced activity as long as minimal capacity for function is maintained. However,…”
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Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function by Baumgart, Bethany R, Wang, Faye, Kwagh, Jae, Storck, Chris, Euler, Catherine, Fuller, Megan, Simic, Damir, Sharma, Suresh, Arnold, Jamie J, Cameron, Craig E, Van Vleet, Terry R, Flint, Oliver, Bunch, Roderick T, Davies, Marc H, Graziano, Michael J, Sanderson, Thomas P

“…BMS-986094, the prodrug of a guanosine nucleotide analogue (2'-C-methylguanosine), was withdrawn from clinical trials due to serious safety issues. Nonclinical…”
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Allogeneic murine pregnancy models for assessing the developmental effects of immune‐stimulating antibodies: Challenges in reproducibility by Thompson, Kary E., Danberry, Tracy L., Bunch, Roderick T., Graziano, Michael J., McNerney, Mary E.

“…Literature suggests that murine allogeneic pregnancy models are an alternative approach for evaluating the developmental toxicity of immune‐stimulating agents…”
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d-α-tocopheryl polyethylene glycol 1000 succinate-containing vehicles provide no detectable chemoprotection from oxidative damage by Baumgart, Bethany R., Van Vleet, Terry R., Simic, Damir, Salcedo, Theodora W., Lentz, Kimberley, Donegan, Michael, Davies, Marc H., Bunch, Roderick T., Sanderson, Thomas P., Lange, Robert W.

“…The objective of this study was to evaluate potential protective effects of vehicles containing d‐α‐tocopheryl polyethylene glycol 1000 succinate (TPGS), which…”
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The Pathologist and Toxicologist in Pharmaceutical Product Discovery by Alden, Carl L., Sagartz, John E., Smith, Peter F., Wilson, Alan G., Bunch, Roderick T., Morris, Dale L.

“…Significant change is occurring in the drug discovery paradigm; many companies are utilizing dedicated groups from the toxicology/ pathology disciplines to…”
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Interspecies differences in renal localization of cyclooxygenase isoforms: implications in nonsteroidal antiinflammatory drug-related nephrotoxicity by Khan, K N, Venturini, C M, Bunch, R T, Brassard, J A, Koki, A T, Morris, D L, Trump, B F, Maziasz, T J, Alden, C L

“…Cyclooxygenase (COX) exists in 2 related but unique isoforms: one is constitutive (COX-1) and functions in normal cell physiology, and the other is inducible…”
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Transcription profiling distinguishes dose-dependent effects in the livers of rats treated with clofibrate by KRAMER, Jeffrey A, BLOMME, Eric A. G, BUNCH, Roderick T, DAVILA, Julio C, JACKSON, Carmen J, JONES, Patrick F, KOLAJA, Kyle L, CURTISS, Sandra W

“…Peroxisome proliferators such as the fibrates act via the peroxisome proliferator activated receptor (PPAR)-alpha as hypolipidemic agents. Many peroxisome…”
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Differential Display in Rat Livers Treated for 13 Weeks with Phenobarbital Implicates a Role for Metabolic and Oxidative Stress in Nongenotoxic Carcinogenicity by Elrick, Mollisa M., Kramer, Jeffrey A., Alden, Carl L., Blomme, Eric A. G., Bunch, Roderick T., Cabonce, Marc A., Curtiss, Sandra W., Kier, Larry D., Kolaja, Kyle L., Rodi, Charles P., Morris, Dale L.

“…Hepatic enzyme inducers such as phenobarbital are often nongenotoxic rodent hepatocarcinogens. Currently, nongenotoxic hepatocarcinogens can only be…”
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Do allogeneic murine pregnancy models predict the developmental liabilities of immune-stimulating antibodies? by Thompson, Kary E., Danberry, Tracy L., Bunch, Roderick T., Graziano, Michael J., McNerney, Mary Ellen

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Revolution through Genomics in Investigative and Discovery Toxicology by Rodi, Charles P., Bunch, Roderick T., Curtiss, Sandra W., Kier, Larry D., Cabonce, Marc A., Davila, Julio C., Mitchell, Michael D., Alden, Carl L., Morris, Dale L.

“…The remarkable technologic and methodologic advances spurred on by the Human Genome Project are being applied throughout the life sciences. In the field of…”
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d-[alpha]-tocopheryl polyethylene glycol 1000 succinate-containing vehicles provide no detectable chemoprotection from oxidative damage by Baumgart, Bethany R, Van Vleet, Terry R, Simic, Damir, Salcedo, Theodora W, Lentz, Kimberley, Donegan, Michael, Davies, Marc H, Bunch, Roderick T, Sanderson, Thomas P, Lange, Robert W

“…The objective of this study was to evaluate potential protective effects of vehicles containing d-[alpha]-tocopheryl polyethylene glycol 1000 succinate (TPGS),…”
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Dissociation between bulk damage to DNA and the antiproliferative activity of teniposide (VM-26) in the MCF-7 breast tumor cell line : evidence for induction of gene-specific damage and alterations in gene expression by GEWIRTZ, D. A, ORR, M. S, FORNARI, F. A, RANDOLPH, J. K, YALOWICH, J. C, RITKE, M. K, POVIRK, L. F, BUNCH, R. T

“…In the MCF-7 breast tumor cell line, induction of bulk damage to DNA (measured either as total strand breaks or as double-strand breaks) fails to correspond…”
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Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor by BUNCH, R. T, EASTMAN, A

“…DNA-damaging agents arrest cell cycle progression at either G1 or G2. A variety of agents such as caffeine have been shown to abrogate the DNA damage-dependent…”
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Transcription Profiling Distinguishes Dose-Dependent Effects in the Livers of Rats Treated with Clofibrate by Kramer, Jeffrey A., Blomme, Eric A.G., Bunch, Roderick T., Davila, Julio C., Jackson, Carmen J., Jones, Patrick F., Kolaja, Kyle L., Curtiss, Sandra W.

“…Peroxisome proliferators such as the fibrates act via the peroxisome proliferator activated receptor (PPAR)-α as hypolipidemic agents. Many peroxisome…”
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Phenobarbital does not promote hepatic tumorigenesis in a twenty-six-week bioassay in p53 heterozygous mice by Sagartz, J E, Curtiss, S W, Bunch, R T, Davila, J C, Morris, D L, Alden, C L

“…The tumorigenic potential of phenobarbital was examined in a 26-wk carcinogenesis bioassay using p53 heterozygous mice and wild-type controls. Fifteen…”
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Influence of amsacrine (m-AMSA) on bulk and gene-specific DNA damage and c-myc expression in MCF-7 breast tumor cells by Bunch, R T, Povirk, L F, Orr, M S, Randolph, J K, Fornari, F A, Gewirtz, D A

“…In the MCF-7 human breast tumor cell line, the aminoacridine, m-AMSA, induces protein-associated DNA strand breaks consistent with inhibition of topoisomerase…”
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Selective damage to the active X chromosome by camptothecin and amsacrine as determined by an allele-specific alkaline unwinding assay by Austin, M.J.Finley, Bunch, Roderick T., Povirk, Lawrence F.

“…Previous studies with MCF-7 cells demonstrated that several agents induce greater strand breakage in active genes than in nontranscribed centromeric regions…”
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7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells by BUNCH, R. T, EASTMAN, A

“…A variety of agents, such as caffeine, have been shown to abrogate the DNA damage-dependent G2 checkpoint and enhance cytotoxicity. However, these agents are…”
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Components of intrinsic drug resistance in the rat hepatoma by Ellis, A L, Munger, C E, Bunch, R T, Woods, K E, Randolph, J K, Boise, L, Swerdlow, P S, Zwelling, L A, Hinds, M, Yanovich, S

“…A carcinogen-transformed rat hepatoma cell line (Reuber H-35) was utilized as a model system for investigation of the biochemical factors which may limit the…”
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