Search Results - "BUNCE, Chris M"

A quick, simple and unbiased method to quantify C2C12 myogenic differentiation by Veliça, Pedro, Bunce, Chris M.

“…Introduction: C2C12 myoblasts undergo in vitro myogenesis to form protein‐rich multinucleated myotubes. Determining the fraction of total nuclei incorporated…”
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Does the pursuit of scientific excellence serve or hamper translational medical research: an historical perspective from hematological malignancies by Bunce, Chris M., Khanim, Farhat L., Drayson, Mark T.

“…Despite enormous global investment, translational medical research faces considerable challenges and patients, and their doctors are frequently frustrated by…”
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Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids by Southam, Andrew D, Khanim, Farhat L, Hayden, Rachel E, Constantinou, Julia K, Koczula, Katarzyna M, Michell, Robert H, Viant, Mark R, Drayson, Mark T, Bunce, Chris M

“…The redeployed drug combination of bezafibrate and medroxyprogesterone acetate (designated BaP) has potent in vivo anticancer activity in acute myelogenous…”
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Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia by Khanim, Farhat L, Hayden, Rachel E, Birtwistle, Jane, Lodi, Alessia, Tiziani, Stefano, Davies, Nicholas J, Ride, Jon P, Viant, Mark R, Gunther, Ulrich L, Mountford, Joanne C, Schrewe, Heinrich, Green, Richard M, Murray, Jim A, Drayson, Mark T, Bunce, Chris M

“…The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also…”
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Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

“…Over recent years, enzymes of the aldo-keto reductase (AKR) 1C subfamily have been implicated in the progression of prostate, breast, endometrial and leukemic…”
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Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance by HAYDEN, Rachel E, PRATT, Guy, DRAYSON, Mark T, BUNCE, Chris M

“…Tumor cells in chronic lymphocytic leukemia accumulate in the periphery through the proliferation of a minority of cells in lymph nodes. The proliferative and…”
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The ‘known-knowns', and ‘known-unknowns' of extracellular Nm23-H1/NDPK proteins by Bunce, Chris M., Khanim, Farhat L.

“…Nucleoside diphosphate kinases (NDPKs/NDK/NME) are a multifunctional class of proteins conserved throughout evolution. Whilst many of the functions of NDPKs…”
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Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing by Jiang, Yao, Southam, Andrew D., Trova, Sandro, Beke, Flavio, Alhazmi, Bader, Francis, Thomas, Radotra, Anshul, di Maio, Alessandro, Drayson, Mark T., Bunce, Chris M., Khanim, Farhat L.

“…Background We previously demonstrated the in vitro killing of AML cells by the combination of the lipid-lowering agent bezafibrate (BEZ) and the contraceptive…”
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Active multiple myeloma suppresses and typically eliminates coexisting MGUS by Campbell, John P, Heaney, Jennifer L J, Pandya, Sankalp, Afzal, Zaheer, Kaiser, Martin, Owen, Roger, Child, J Anthony, Gregory, Walter, Morgan, Gareth J, Jackson, Graham H, Bunce, Chris M, Drayson, Mark T

“…Background: Myeloma is consistently preceded by premalignant monoclonal gammopathy of undetermined significance (MGUS). In >5% of MGUS patients there is a…”
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AKR1C Isoforms Represent a Novel Cellular Target for Jasmonates alongside Their Mitochondrial-Mediated Effects by DAVIES, Nicholas J, HAYDEN, Rachel E, SIMPSON, Paul J, BIRTWISTLE, Jane, MAYER, Katarina, RIDE, Jonathan P, BUNCE, Chris M

“…Members of the aldo-keto reductase (AKR) superfamily, particularly the AKR1C subfamily, are emerging as important mediators of the pathology of cancer. Agents…”
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Prostaglandin D2 inhibits C2C12 myogenesis by Veliça, Pedro, Khanim, Farhat L, Bunce, Chris M

“…Muscle repair following injury is preceded by a rapid inflammatory response with myoblasts being exposed to high levels of prostaglandin D(2) (PGD(2)) from…”
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Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches by Hayden, Rachel E., Pratt, Guy, Roberts, Claudia, Drayson, Mark T., Bunce, Chris M.

“…Abstract Chronic lymphocytic leukemia (CLL) remains associated with low complete response rates and high relapse rates. This is in part due to poor…”
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Prostaglandins in muscle regeneration by Veliça, Pedro, Bunce, Chris M

“…Muscle regeneration is a tightly orchestrated process where activated satellite cells (myoblasts) respond to external stimuli in order to proliferate,…”
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Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML) by Murray, Jim A., Khanim, Farhat L., Hayden, Rachel E., Craddock, Charlie F., Holyoake, Tessa L., Jackson, Nick, Lumley, Matthew, Bunce, Chris M., Drayson, Mark T.

“…Summary Acute myeloid leukaemia (AML) causes life‐threatening deficits of functional blood cells that require management using red cell and platelet…”
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Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy: a retrospective cohort study by Campbell, John P, Heaney, Jennifer L J, Pandya, Sankalp, Afzal, Zaheer, Kaiser, Martin, Owen, Roger, Child, J Anthony, Cairns, David A, Gregory, Walter, Morgan, Gareth J, Jackson, Graham H, Bunce, Chris M, Drayson, Mark T

“…Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS), which is usually only treated by a form of…”
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Elevated FOSB‐expression; a potential marker of valproate sensitivity in AML by Khanim, Farhat L., Bradbury, Charlotte A., Arrazi, Julie, Hayden, Rachel E., Rye, Adam, Basu, Supratik, MacWhannell, Alan, Sawers, Alistair, Griffiths, Michael, Cook, Mark, Freeman, Sylvie, Nightingale, Karl P., Grimwade, David, Falciani, Francesco, Turner, Bryan M., Bunce, Chris M., Craddock, Charles

“…Summary Histone deacetylase inhibitors (HDIs) are emerging as valuable new agents in the treatment of acute myeloid leukaemia (AML). However, since response…”
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The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis by Birtwistle, Jane, Hayden, Rachel E, Khanim, Farhat L, Green, Richard M, Pearce, Claire, Davies, Nicholas J, Wake, Naomi, Schrewe, Heiner, Ride, Jonathan P, Chipman, James K, Bunce, Chris M

“…The aldo-keto reductase AKR1C3, has been shown to regulate myelopoiesis via its ability to metabolise prostaglandin D2 (PGD2). Other studies have demonstrated…”
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Erratum to: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

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Correction: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

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Prostaglandin D 2 inhibits C2C12 myogenesis by Veliça, Pedro, Khanim, Farhat L., Bunce, Chris M.

“…Muscle repair following injury is preceded by a rapid inflammatory response with myoblasts being exposed to high levels of prostaglandin D 2 (PGD 2) from…”
Get full text