Search Results - "BUMPUS, Namandjé N"

Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry by Orsburn, Benjamin C., Yuan, Yuting, Bumpus, Namandjé N.

“…Single cell proteomics is a powerful tool with potential for markedly enhancing understanding of cellular processes. Here we report the development and…”
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For better drugs, diversify clinical trials by Bumpus, Namandjé N

“…Genetic variation in drug metabolism can affect drug outcomes COVID-19 has highlighted the devastating disparities that exist for Black, Latinx, and Indigenous…”
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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities by Zhang, Donglu, Hop, Cornelis E C A, Patilea-Vrana, Gabriela, Gampa, Gautham, Seneviratne, Herana Kamal, Unadkat, Jashvant D, Kenny, Jane R, Nagapudi, Karthik, Di, Li, Zhou, Lian, Zak, Mark, Wright, Matthew R, Bumpus, Namandjé N, Zang, Richard, Liu, Xingrong, Lai, Yurong, Khojasteh, S Cyrus

“…The well accepted "free drug hypothesis" for small-molecule drugs assumes that only the free (unbound) drug concentration at the therapeutic target can elicit…”
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Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer by Seamon, Kyle J, Bumpus, Namandjé N, Stivers, James T

“…Sterile alpha motif and HD domain protein 1 (SAMHD1) is a unique enzyme that plays important roles in nucleic acid metabolism, viral restriction, and the…”
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The role of FDA advisory committees by Helms Williams, Emily C., Bumpus, Namandjé N., Califf, Robert M.

“…FDA advisory committees provide useful recommendations for decision-making, but optimization efforts could help reduce burdens and improve public understanding…”
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Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066) by Hendrix, Craig W, Andrade, Adriana, Bumpus, Namandjé N, Kashuba, Angela D, Marzinke, Mark A, Moore, Ayana, Anderson, Peter L, Bushman, Lane R, Fuchs, Edward J, Wiggins, Ilene, Radebaugh, Christine, Prince, Heather A, Bakshi, Rahul P, Wang, Ruili, Richardson, Paul, Shieh, Eugenie, McKinstry, Laura, Li, Xin, Donnell, Deborah, Elharrar, Vanessa, Mayer, Kenneth H, Patterson, Kristine B

“…Oral preexposure prophylaxis (PrEP) trials report disparate efficacy attributed to variable adherence. HPTN 066 was conducted to establish objective,…”
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Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice by Avery, Lindsay B, Bumpus, Namandjé N

“…Valproic acid (VPA) is a widely prescribed anticonvulsant for the treatment of epilepsy. Here we demonstrate that VPA is a novel activator of AMP-activated…”
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Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro by Mosher, Eric P, Eberhard, Colten D, Bumpus, Namandjé N

“…Tenofovir (TFV) is a key component of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP). TFV is a nucleotide analog reverse-transcriptase…”
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Pharmacogenomics of Antiretroviral Drug Metabolism and Transport by Yu, Zaikuan J, Mosher, Eric P, Bumpus, Namandjé N

“…Antiretroviral therapy has markedly reduced morbidity and mortality for persons living with human immunodeficiency virus (HIV). Individual tailoring of…”
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Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes by Bumpus, Namandjé N.

“…Chronic use of efavirenz (EFV) has been linked to incidences of hepatotoxicity in patients receiving EFV to treat HIV-1. While recent studies have demonstrated…”
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Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain by Washington-Hughes, Clorissa L, Roy, Shubhrajit, Seneviratne, Herana Kamal, Karuppagounder, Senthilkumar S, Morel, Yulemni, Jones, Jace W, Zak, Alex, Xiao, Tong, Boronina, Tatiana N, Cole, Robert N, Bumpus, Namandjé N, Chang, Christopher J, Dawson, Ted M, Lutsenko, Svetlana

“…Copper (Cu) has a multifaceted role in brain development, function, and metabolism. Two homologous Cu transporters, Atp7a (Menkes disease protein) and Atp7b…”
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Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism by Yanakakis, Lindsay J, Bumpus, Namandjé N

“…Etravirine (ETR) is a second-generation non-nucleoside reverse transcriptase inhibitor prescribed for the treatment of HIV-1. By using human liver microsomes…”
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Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc by Lu, Yanhui, Hendrix, Craig W, Bumpus, Namandjé N

“…Maraviroc is an anti-human immunodeficiency virus drug that acts by blocking viral entry into target cells. With use of ultra-performance liquid…”
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Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death by Heck, Carley J. S, Seneviratne, Herana Kamal, Bumpus, Namandjé N

“…Cytochrome P450-dependent metabolism of the anti-HIV drug nevirapine (NVP) to 12-hydroxy-NVP (12-OHNVP) has been implicated in NVP toxicities. We investigated…”
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The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module by Haile, Sara T., Rahman, Sanim, Fields, James K., Orsburn, Benjamin C., Bumpus, Namandjé N., Wolberger, Cynthia

“…The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex is a transcriptional co-activator that both acetylates and deubiquitinates histones. The histone…”
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A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1–Infected Adults on Antiretroviral Therapy by Spivak, Adam M., Andrade, Adriana, Eisele, Evelyn, Hoh, Rebecca, Bacchetti, Peter, Bumpus, Namandjé N., Emad, Fatemeh, Buckheit, Robert, McCance-Katz, Elinore F., Lai, Jun, Kennedy, Margene, Chander, Geetanjali, Siliciano, Robert F., Siliciano, Janet D., Deeks, Steven G.

“…Background. Transcriptionally silent human immunodeficiency virus type 1 (HIV-1) DNA persists in resting memory CD4 + T cells despite antiretroviral therapy…”
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Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications by Hollenberg, Paul F, Kent, Ute M, Bumpus, Namandjé N

“…The P450 type cytochromes are responsible for the metabolism of a wide variety of xenobiotics and endogenous compounds. Although P450-catalyzed reactions are…”
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Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1 α -XBP1 by Heck, Carley J S, Hamlin, Allyson N, Bumpus, Namandjé N

“…Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates…”
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Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir by Hamlin, Allyson N, Tillotson, Joseph, Bumpus, Namandjé N

“…As antiretroviral therapy has become more accessible across the world and coformulations have improved patient compliance; the morbidity and mortality of…”
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Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison by LADE, Julie M, AVERY, Lindsay B, BUMPUS, Namandjé N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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