Search Results - "BULMER, Judith N"

Uterine natural killer cells: Time for a re-appraisal? [version 1; peer review: 2 approved] by Bulmer, Judith N, Lash, Gendie E

“…The presence of unusual natural killer cells in human endometrium has been recognized for 30 years, but despite considerable research effort, the in vivo role…”
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Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy by Lash, Gendie E., Schiessl, Barbara, Kirkley, Maureen, Innes, Barbara A., Cooper, Alix, Searle, Roger F., Robson, Stephen C., Bulmer, Judith N.

“…Remodeling of uterine spiral arteries is critical for the continuation of a successful pregnancy. Uterine natural killer (uNK) cells are the predominant…”
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The role of vascular smooth muscle cell apoptosis and migration during uterine spiral artery remodeling in normal human pregnancy by Bulmer, Judith N., Innes, Barbara A., Levey, Joanne, Robson, Stephen C., Lash, Gendie E.

“…ABSTRACT During human uterine spiral artery (SpA) remodeling, vascular smooth muscle cells (VSMCs) are lost and replaced by fibrinoid, incorporating…”
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Do uterine natural killer (uNK) cells contribute to female reproductive disorders? by Lash, Gendie E, Bulmer, Judith N

“…Abstract The most abundant immune cells in the uterine decidua around the time of implantation and early placental development are the uterine natural killer…”
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Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy by Williams, Paula J, Bulmer, Judith N, Searle, Roger F, Innes, Barbara A, Robson, Stephen C

“…Alterations in the balance of leucocyte populations in uterine decidua may lead to the generation of an unfavourable cytokine environment that is associated…”
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Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction: Relationship to Clinical Outcome by LYALL, Fiona, ROBSON, Stephen C, BULMER, Judith N

“…Failure to transform uteroplacental spiral arteries is thought to underpin disorders of pregnancy, including preeclampsia and fetal growth restriction (FGR)…”
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Maternal HIV Infection and Placental Malaria Reduce Transplacental Antibody Transfer and Tetanus Antibody Levels in Newborns in Kenya by Cumberland, Phillippa, Shulman, Caroline E., Chris Maple, P. A., Bulmer, Judith N., Dorman, Edgar K., Kawuondo, Ken, Marsh, Kevin, Cutts, Felicity T.

“…Background. In clinical trials, maternal tetanus toxoid (TT) vaccination is effective in protecting newborns against tetanus infection, but inadequate…”
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Interaction between uterine natural killer cells and extravillous trophoblast cells: effect on cytokine and angiogenic growth factor production by Lash, Gendie E., Naruse, Katsuhiko, Robson, Andrew, Innes, Barbara A., Searle, Roger F., Robson, Stephen C., Bulmer, Judith N.

“…BACKGROUND Uterine natural killer (uNK) cells are a major source of cytokines and angiogenic growth factors (AGFs), with AGF levels decreasing and cytokine…”
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Transforming Growth Factor (TGF) β and Endometrial Vascular Maturation by Lu, Qinsheng, Sun, Dingqian, Shivhare, Sourima Biswas, Hou, Huomei, Bulmer, Judith N, Innes, Barbara A, Hapangama, Dharani K, Lash, Gendie E

“…Appropriate growth and development of the endometrium across the menstrual cycle is key for a woman's quality of life and reproductive well-being. Recurrent…”
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Inflammatory Signalling in Fetal Membranes: Increased Expression Levels of TLR 1 in the Presence of Preterm Histological Chorioamnionitis by Waring, Gareth J, Robson, Stephen C, Bulmer, Judith N, Tyson-Capper, Alison J

“…Histological chorioamnionitis (HCA) is an established marker of ascending infection, a major cause of preterm birth. No studies have characterised the global…”
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Inhibition of Trophoblast Cell Invasion by TGFB1, 2, and 3 Is Associated with a Decrease in Active Proteases by Lash, Gendie E, Otun, Harry A, Innes, Barbara A, Bulmer, Judith N, Searle, Roger F, Robson, Stephen C

“…Invasion of extravillous trophoblast cells into the uterus in human pregnancy is tightly regulated. The transforming growth factor-beta (TGFB) family has been…”
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Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy by Naruse, Katsuhiko, Innes, Barbara A, Bulmer, Judith N, Robson, Stephen C, Searle, Roger F, Lash, Gendie E

“…Abstract Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy…”
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Single-cell reconstruction of the early maternal–fetal interface in humans by Vento-Tormo, Roser, Efremova, Mirjana, Botting, Rachel A., Turco, Margherita Y., Vento-Tormo, Miquel, Meyer, Kerstin B., Park, Jong-Eun, Stephenson, Emily, Polański, Krzysztof, Goncalves, Angela, Gardner, Lucy, Holmqvist, Staffan, Henriksson, Johan, Zou, Angela, Sharkey, Andrew M., Millar, Ben, Innes, Barbara, Wood, Laura, Wilbrey-Clark, Anna, Payne, Rebecca P., Ivarsson, Martin A., Lisgo, Steve, Filby, Andrew, Rowitch, David H., Bulmer, Judith N., Wright, Gavin J., Stubbington, Michael J. T., Haniffa, Muzlifah, Moffett, Ashley, Teichmann, Sarah A.

“…During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells…”
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Effector Activity of Decidual CD8+ T Lymphocytes in Early Human Pregnancy by SCAIFE, Paula J, BULMER, Judith N, ROBSON, Stephen C, INNES, Barbara A, SEARLE, Roger F

“…Although CD8 + T lymphocytes are present in human decidua throughout pregnancy, albeit as a minor population in early pregnancy, their role in normal pregnancy…”
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Decidual macrophages: key regulators of vascular remodeling in human pregnancy by Lash, Gendie E., Pitman, Hedele, Morgan, Hannah L., Innes, Barbara A., Agwu, Chinedu N., Bulmer, Judith N.

“…Decidual macrophages phagocytose apoptotic VSMC during remodeling of the uterine spiral arteries during early human pregnancy. Successful remodeling of the…”
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Neonatal Measles Immunity in Rural Kenya: The Influence of HIV and Placental Malaria Infections on Placental Transfer of Antibodies and Levels of Antibody in Maternal and Cord Serum Samples by Scott, Susana, Cumberland, Phillippa, Shulman, Caroline E, Cousens, Simon, Cohen, Bernard J, Brown, David W. G, Bulmer, Judith N, Dorman, Edgar K, Kawuondo, Ken, Marsh, Kevin, Cutts, Felicity

“…IntroductionYoung infants are protected from measles infection by maternal measles antibodies. The level of these antibodies at birth depends on the level of…”
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Uterine natural killer cells initiate spiral artery remodeling in human pregnancy by Robson, Andrew, Harris, Lynda K., Innes, Barbara A., Lash, Gendie E., Aljunaidy, Mais M., Aplin, John D., Baker, Philip N., Robson, Stephen C., Bulmer, Judith N.

“…Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late…”
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Immune cells in the placental bed by Bulmer, Judith N, Williams, Paula J, Lash, Gendie E

“…Leukocytes are an important component of the human uterine decidua in normal pregnancy. The focus of research has been on the more abundant populations such as…”
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Low Oxygen Concentrations Inhibit Trophoblast Cell Invasion from Early Gestation Placental Explants via Alterations in Levels of the Urokinase Plasminogen Activator System by LASH, Gendie E, OTUN, Harry A, INNES, Barbara A, BULMER, Judith N, SEARLE, Roger F, ROBSON, Stephen C

“…Extravillous trophoblast cell (EVT) invasion in early pregnancy occurs in a relatively low-oxygen environment. The role of oxygen in regulation of EVT invasion…”
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Are we managing women with Recurrent Miscarriage appropriately? A snapshot survey of clinical practice within the United Kingdom by Manning, Rashmi, Iyer, Janani, Bulmer, Judith N, Maheshwari, Abha, Choudhary, Meenakshi

“…The aim of this study was to evaluate clinicians' views of managing women with first-trimester Recurrent Miscarriage within the UK compared with RCOG guidance…”
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