Search Results - "BULLOCK, Ross"

Inflammasome proteins as biomarkers of traumatic brain injury by Kerr, Nadine, Lee, Stephanie W, Perez-Barcena, Jon, Crespi, Catalina, Ibañez, Javier, Bullock, M Ross, Dietrich, W Dalton, Keane, Robert W, de Rivero Vaccari, Juan Pablo

“…The inflammasome plays an important role in the inflammatory innate immune response after central nervous system (CNS) injury. Inhibition of the inflammasome…”
Get full text

Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial by Okonkwo, David O., Shutter, Lori A., Moore, Carol, Temkin, Nancy R., Puccio, Ava M., Madden, Christopher J., Andaluz, Norberto, Chesnut, Randall M., Bullock, M. Ross, Grant, Gerald A., McGregor, John, Weaver, Michael, Jallo, Jack, LeRoux, Peter D., Moberg, Dick, Barber, Jason, Lazaridis, Christos, Diaz-Arrastia, Ramon R.

“…A relationship between reduced brain tissue oxygenation and poor outcome following severe traumatic brain injury has been reported in observational studies. We…”
Get full text

Exosome‐mediated inflammasome signaling after central nervous system injury by Rivero Vaccari, Juan Pablo, Brand, Frank, Adamczak, Stephanie, Lee, Stephanie W., Perez‐Barcena, Jon, Wang, Michael Y., Bullock, M. Ross, Dietrich, W. Dalton, Keane, Robert W.

“…Neuroinflammation is a response against harmful effects of diverse stimuli and participates in the pathogenesis of brain and spinal cord injury (SCI). The…”
Get full text

Past, Present, and Future of Traumatic Brain Injury Research by Hawryluk, Gregory W.J., MD, PhD, Bullock, Ross, MD, PhD

“…Traumatic brain injury (TBI) is the greatest cause of death and severe disability in young adults; its incidence is increasing in the elderly and in the…”
Get full text

Moderate and severe traumatic brain injury in adults by Maas, Andrew IR, MD, Stocchetti, Nino, MD, Bullock, Ross, MD

“…Summary Traumatic brain injury (TBI) is a major health and socioeconomic problem that affects all societies. In recent years, patterns of injury have been…”
Get full text

Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study by Hartings, Jed A, Dr, Bullock, M Ross, MD, Okonkwo, David O, MD, Murray, Lilian S, PhD, Murray, Gordon D, PhD, Fabricius, Martin, DMSc, Maas, Andrew IR, MD, Woitzik, Johannes, MD, Sakowitz, Oliver, MD, Mathern, Bruce, MD, Roozenbeek, Bob, MD, Lingsma, Hester, PhD, Dreier, Jens P, MD, Puccio, Ava M, PhD, Shutter, Lori A, MD, Pahl, Clemens, MD, Strong, Anthony J, MD

“…Summary Background Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50–60%…”
Get full text

Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury by Lee, Stephanie W, Gajavelli, Shyam, Spurlock, Markus S, Andreoni, Cody, de Rivero Vaccari, Juan Pablo, Bullock, M Ross, Keane, Robert W, Dietrich, W Dalton

“…Penetrating traumatic brain injury (PTBI) is a significant cause of death and disability in the United States. Inflammasomes are one of the key regulators of…”
Get more information

Levels of caspase-1 in cerebrospinal fluid of patients with traumatic brain injury: correlation with intracranial pressure and outcome by Pérez-Bárcena, Jon, Crespí, Catalina, Frontera, Guillem, Llompart-Pou, Juan Antonio, Salazar, Osman, Goliney, Victor, Ibáñez, Javier, Bullock, M Ross, de Rivero Vaccari, Juan Pablo

“…The objectives of this study were to evaluate levels of inflammasome-signaling proteins in serum and CSF of patients with traumatic brain injury (TBI), and to…”
Get full text

Biomarkers for the Clinical Differential Diagnosis in Traumatic Brain Injury—A Systematic Review by Yokobori, Shoji, Hosein, Khadil, Burks, Stephen, Sharma, Ishna, Gajavelli, Shyam, Bullock, Ross

“…Summary Rapid triage and decision‐making in the treatment of traumatic brain injury (TBI) present challenging dilemma in “resource poor” environments such as…”
Get full text

A critical analysis of the role of the neurotrophic protein S100B in acute brain injury by Kleindienst, Andrea, Ross Bullock, M

“…We provide a critical analysis of the relevance of S100B in acute brain injury emphazising the beneficial effect of its biological properties. S100B is a…”
Get more information

Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study by Mondello, Stefania, Papa, Linda, Buki, Andras, Bullock, M Ross, Czeiter, Endre, Tortella, Frank C, Wang, Kevin K, Hayes, Ronald L

“…Authors of several studies have studied biomarkers and computed tomography (CT) findings in the acute phase after severe traumatic brain injury (TBI). However,…”
Get full text

Outcome and Surgical Management for Geriatric Traumatic Brain Injury: Analysis of 888 Cases Registered in the Japan Neurotrauma Data Bank by Shimoda, Kentaro, Maeda, Takeshi, Tado, Masahiro, Yoshino, Atsuo, Katayama, Yoichi, Bullock, M. Ross

“…Objective As the aged population is rapidly growing globally, geriatric traumatic brain injury (TBI) becomes an increasing problem. There are higher mortality…”
Get full text

Low-Dose Recombinant Tissue-Type Plasminogen Activator Enhances Clot Resolution in Brain Hemorrhage: The Intraventricular Hemorrhage Thrombolysis Trial by NAFF, Neal, WILLIAMS, Michael A, ZUCCARELLO, Mario, BROCK, David, AWAD, Issam, ZIAI, Wendy C, MARMAROU, Anthony, RHONEY, Denise, MCBEE, Nichol, LANE, Karen, HANLEY, Daniel F, KEYL, Penelope M, TUHRIM, Stanley, ROSS BULLOCK, M, MAYER, Stephan A, COPLIN, William, NARAYAN, Raj, HAINES, Stephen, CRUZ-FLORES, Salvador

“…Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy…”
Get full text

The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI by Mazzeo, Anna Teresa, Beat, Alessandri, Singh, Amanpreet, Bullock, M. Ross

“…Following severe traumatic brain injury (TBI), a complex interplay of pathomechanism, such as exitotoxicity, oxidative stress, inflammatory events, and…”
Get full text

Subdural hematoma decompression model: A model of traumatic brain injury with ischemic-reperfusional pathophysiology: A review of the literature by Yokobori, Shoji, Nakae, Ryuta, Yokota, Hiroyuki, Spurlock, Markus S., Mondello, Stefania, Gajavelli, Shyam, Bullock, Ross M.

“…•The prognosis for traumatic brain injury (TBI) patients with subdural hematoma (SDH) remains poor.•Removal of the SDH results in the immediate reversal of…”
Get full text

Editorial: Cerebral microdialysis by Chen, Jefferson W., Valadka, Alex B., Ross Bullock, M., Carpenter, Keri L. H.

Get full text

Classification of traumatic brain injury for targeted therapies by Saatman, Kathryn E, Duhaime, Ann-Christine, Bullock, Ross, Maas, Andrew I R, Valadka, Alex, Manley, Geoffrey T

“…The heterogeneity of traumatic brain injury (TBI) is considered one of the most significant barriers to finding effective therapeutic interventions. In…”
Get more information

New astroglial injury-defined biomarkers for neurotrauma assessment by Halford, Julia, Shen, Sean, Itamura, Kyohei, Levine, Jaclynn, Chong, Albert C, Czerwieniec, Gregg, Glenn, Thomas C, Hovda, David A, Vespa, Paul, Bullock, Ross, Dietrich, W Dalton, Mondello, Stefania, Loo, Joseph A, Wanner, Ina-Beate

“…Traumatic brain injury (TBI) is an expanding public health epidemic with pathophysiology that is difficult to diagnose and thus treat. TBI biomarkers should…”
Get full text

Acute Diagnostic Biomarkers for Spinal Cord Injury: Review of the Literature and Preliminary Research Report by Yokobori, Shoji, Zhang, Zhiqun, Moghieb, Ahmed, Mondello, Stefania, Gajavelli, Shyam, Dietrich, W. Dalton, Bramlett, Helen, Hayes, Ronald L, Wang, Michael, Wang, Kevin K.W, Bullock, M. Ross

“…Objective Many efforts have been made to create new diagnostic technologies for use in the diagnosis of central nervous system injury. However, there is still…”
Get full text

Spreading depolarizations and late secondary insults after traumatic brain injury by Hartings, Jed A, Strong, Anthony J, Fabricius, Martin, Manning, Andrew, Bhatia, Robin, Dreier, Jens P, Mazzeo, Anna Teresa, Tortella, Frank C, Bullock, M Ross

“…Here we investigated the incidence of cortical spreading depolarizations (spreading depression and peri-infarct depolarization) after traumatic brain injury…”
Get more information