Search Results - "BULLERDIEK, Jorn"

Causal discovery of gene regulation with incomplete data by Foraita, Ronja, Friemel, Juliane, Günther, Kathrin, Behrens, Thomas, Bullerdiek, Jörn, Nimzyk, Rolf, Ahrens, Wolfgang, Didelez, Vanessa

“…Causal discovery algorithms aim to identify causal relations from observational data and have become a popular tool for analysing genetic regulatory systems…”
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Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: A proof of principle by Gillis, Ad J.M., Rijlaarsdam, Martin A., Eini, Ronak, Dorssers, Lambert C.J., Biermann, Katharina, Murray, Matthew J., Nicholson, James C., Coleman, Nicholas, Dieckmann, Klaus-Peter, Belge, Gazanfer, Bullerdiek, Jörn, Xu, Tom, Bernard, Nathalie, Looijenga, Leendert H.J.

“…Germ cell cancers (GCC) are the most frequent malignancy in young Caucasian males. GCC can consist of seminomas (SE) and non-seminomas (malignant NS: embryonal…”
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MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid by Dieckmann, Klaus-Peter, Spiekermann, Meike, Balks, Thomas, Ikogho, Raphael, Anheuser, Petra, Wosniok, Werner, Loening, Thomas, Bullerdiek, Jörn, Belge, Gazanfer

“…microRNAs (miRs)-371-3 are suggested to be novel biomarkers of germ cell tumors (GCTs), but their specificity is unresolved. We aimed at clarifying the origin…”
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Angiogenetic Signaling through Hypoxia: HMGB1: An Angiogenetic Switch Molecule by Schlueter, Claudia, Weber, Holger, Meyer, Britta, Rogalla, Piere, Roser, Kerstin, Hauke, Sven, Bullerdiek, Jorn

“…The initiation of angiogenesis, called the angiogenetic switch, is a crucial early step in tumor progression and propagation, ensuring an adequate oxygen…”
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Expression of microRNAs of C19MC in Different Histological Types of Testicular Germ Cell Tumour by Flor, Inga, Spiekermann, Meike, Löning, Thomas, Dieckmann, Klaus-Peter, Belge, Gazanfer, Bullerdiek, Jörn

“…Testicular germ cell tumours (TGCTs) are the most common tumours in men aged from 20 to 40 years, with a steadily increasing incidence. This study aimed to…”
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Patterns of Chromosomal Abnormalities that Can Improve Diagnosis of Uterine Smooth Muscle Tumors by Holzmann, Carsten, Markowski, Dominique Nadine, VON Leffern, Ingo, Löning, Thomas, Bullerdiek, Jörn

“…Compared to leiomyomas, smooth muscle tumors of uncertain malignant potential (STUMP), and leiomyosarcomas (LMS) originating from the Muellerian duct are very…”
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Upregulation of HMGA2 in thyroid carcinomas: A novel molecular marker to distinguish between benign and malignant follicular neoplasias by Belge, Gazanfer, Meyer, Anke, Klemke, Markus, Burchardt, Käte, Stern, Corinna, Wosniok, Werner, Loeschke, Siegfried, Bullerdiek, Jörn

“…The identification of molecular markers allowing to differentiate between benign and malignant thyroid tumors remains a diagnostic challenge. Herein, we have…”
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Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease by Klemke, Markus, Meyer, Anke, Nezhad, Maliheh Hashemi, Bartnitzke, Sabine, Drieschner, Norbert, Frantzen, Christiane, Schmidt, Ernst Heinrich, Belge, Gazanfer, Bullerdiek, Jörn

“…An overexpression of HMGA2 is supposed to be a key event in the genesis of leiomyoma with chromosomal rearrangements affecting the region 12q14‐15 targeting…”
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Pretreatment oral hygiene habits and survival of head and neck squamous cell carcinoma (HNSCC) patients by Friemel, Juliane, Foraita, Ronja, Günther, Kathrin, Heibeck, Mathias, Günther, Frauke, Pflueger, Maren, Pohlabeln, Hermann, Behrens, Thomas, Bullerdiek, Jörn, Nimzyk, Rolf, Ahrens, Wolfgang

“…The survival time of patients with head and neck squamous cell carcinoma (HNSCC) is related to health behavior, such as tobacco smoking and alcohol…”
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A rare coincidence of different types of driver mutations among uterine leiomyomas (UL) by Holzmann, Carsten, Markowski, Dominique Nadine, Bartnitzke, Sabine, Koczan, Dirk, Helmke, Burkhard Maria, Bullerdiek, Jörn

“…Mutations of mediator subcomplex 12 (MED12) and of high mobility group protein AT-hook 2 (HMGA2) are driver mutations in uterine leiomyomas (UL) that have not…”
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TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A) by Willenbrock, Saskia, Braun, Olga, Baumgart, Judith, Lange, Sandra, Junghanss, Christian, Heisterkamp, Alexander, Nolte, Ingo, Bullerdiek, Jörn, Murua Escobar, Hugo

“…► Recombinant HMGB1 secretion by TNF-α or IFN-γ stimulation in mammary cells. ► HMGB1 release kinetics showed a clear peak release 24 h after TNF-α…”
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Cytogenetically normal uterine leiomyomas without MED12-mutations - a source to identify unknown mechanisms of the development of uterine smooth muscle tumors by Holzmann, Carsten, Markowski, Dominique Nadine, Koczan, Dirk, Küpker, Wolfgang, Helmke, Burkhard Maria, Bullerdiek, Jörn

“…Recent findings on genetic changes in uterine leiomyomas suggest these benign tumors being a heterogeneous group of diseases in terms of molecular pathogenesis…”
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HMGA2 expression in the PC-3 prostate cancer cell line is autonomous of growth factor stimulation by Müller, Marietta Henrike, Drieschner, Norbert, Focken, Tim, Bartnitzke, Sabine, Winter, Nina, Klemke, Markus, Bullerdiek, Jörn

“…High-mobility group AT-hook 2 (HMGA2) protein acts as an oncofoetal transcriptional regulator. In mesenchymal tissues, its expression can be induced by a…”
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Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas by RIPPE, Volkhard, DRIESCHNER, Norbert, MEIBOOM, Maren, ESCOBAR, Hugo Murua, BONK, Ulrich, BELGE, Gazanfer, BULLERDIEK, Jörn

“…Thyroid adenomas belong to the cytogenetically best investigated human epithelial tumors. Cytogenetic studies of about 450 benign lesions allow one to…”
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Genome-wide acquired uniparental disomy as well as chromosomal gains and losses in an uterine epithelioid leiomyoma by Holzmann, Carsten, Markowski, Dominique Nadine, Koczan, Dirk, Helmke, Burkhard Maria, Bullerdiek, Jörn

“…Epitheloid leiomyoma is a rare subtype of benign smooth muscle tumors. Herein, we present the results of classical cytogenetics, MED12 mutation analysis, and…”
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Non-Hodgkin lymphoma expressing high levels of the danger-signalling protein HMGB1 by Meyer, Anke, Staratschek-Jox, Andrea, Springwald, Anette, Wenk, Heiner, Wolf, Jürgen, Wickenhauser, Claudia, Bullerdiek, Jörn

“…HMGB1 is a high mobility group protein that can act either as a DNA binding protein or extracellularly as a cytokine-like danger signal. Extracellular HMGB1,…”
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p14Arf acts as an antagonist of HMGA2 in senescence of mesenchymal stem cells-implications for benign tumorigenesis by Markowski, Dominique Nadine, Winter, Nina, Meyer, Frauke, von Ahsen, Inga, Wenk, Heiner, Nolte, Ingo, Bullerdiek, Jörn

“…HMGA2 is a major regulator of benign tumorigenesis from mesenchyme‐derived tissues and stem‐cell self‐renewal. It has been postulated that HMGA2 mediates its…”
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Activation of the two microRNA clusters C19MC and miR-371-3 does not play prominent role in thyroid cancer by Rippe, Volkhard, Flor, Inga, Debler, Johannes Wolfram, Drieschner, Norbert, Rommel, Birgit, Krause, Daniel, Junker, Klaus, Bullerdiek, Jörn

“…Chromosomal rearrangements of band 19q13.4 are frequent cytogenetic alterations in benign thyroid adenomas. Apparently, these alterations lead to the…”
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Quantitative PCR and Immunohistochemical Analyses of HMGB1 and RAGE Expression in Canine Disseminated Histiocytic Sarcoma (Malignant Histiocytosis) by STERENCZAK, Katharina A, KLEINSCHMIDT, Sven, WEFSTAEDT, Patrick, EBERLE, Nina, HEWICKER-TRAUTWEIN, Marion, BULLERDIEK, Jorn, NOLTE, Ingo, MURUA ESCOBAR, Hugo

“…Disorders of histiocytic origin affecting humans and dogs share various similarities. Canine disseminated histiocytic sarcoma (DHS) (formerly known as…”
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Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability by Markowski, Dominique Nadine, Nimzyk, Rolf, Belge, Gazanfer, Löning, Thomas, Helmke, Burkhard Maria, Bullerdiek, Jörn

“…Deletions of the gene encoding mediator subcomplex 12 (MED12) in human smooth muscle tumors rank among the most frequent genomic alterations in human tumors at…”
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