Search Results - "BULLER, Benjamin"

Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system by Zhang, Jing, Buller, Benjamin A., Zhang, Zheng Gang, Zhang, Yi, Lu, Mei, Rosene, Douglas L., Medalla, Maria, Moore, Tara L., Chopp, Michael

“…Injury of oligodendrocytes (OLs) induces demyelination, and patients with neurodegenerative diseases exhibit demyelination concomitantly with neurological…”
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Functional MicroRNA Is Transferred between Glioma Cells by KATAKOWSKI, Mark, BULLER, Benjamin, XINLI WANG, ROGERS, Thomas, CHOPP, Michael

“…MicroRNAs (miRNA) are single-stranded 17- to 27-nucleotide RNA molecules that regulate gene expression by posttranscriptional silencing of target mRNAs. Here,…”
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MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3 by Zheng, Xuguang, Chopp, Michael, Lu, Yong, Buller, Benjamin, Jiang, Feng

“…Highlights ► Invasion and angiogenesis related mRNA expression and miRNA profiles of glioma were tested and miR-15b and miR-152 were selected for further…”
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The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical neurons by Zhang, Yi, Ueno, Yuji, Liu, Xian Shuang, Buller, Benjamin, Wang, Xinli, Chopp, Michael, Zhang, Zheng Gang

“…MicroRNAs (miRNAs) regulate dendritogenesis and plasticity. However, the biological function of miRNAs in axons has not been extensively investigated. Here,…”
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Early single-dose exosome treatment improves neurologic outcomes in a 7-day swine model of traumatic brain injury and hemorrhagic shock by Williams, Aaron M., Wu, Zhenyu, Bhatti, Umar F., Biesterveld, Ben E., Kemp, Michael T., Wakam, Glenn K., Vercruysse, Claire A., Chtraklin, Kiril, Siddiqui, Ali Z., Pickell, Zachary, Dekker, Simone E., Tian, Yuzi, Liu, Baoling, Li, Yongqing, Buller, Benjamin, Alam, Hasan B.

“…Early single-dose treatment with human mesenchymal stem cell-derived exosomes promotes neuroprotection and promotes blood-brain barrier integrity in models of…”
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Axonal Outgrowth and Dendritic Plasticity in the Cortical Peri-Infarct Area After Experimental Stroke by YUJI UENO, CHOPP, Michael, LI ZHANG, BULLER, Benjamin, ZHONGWU LIU, LEHMAN, Norman L, XIAN SHUANG LIU, YI ZHANG, ROBERTS, Cynthia, ZHENG GANG ZHANG

“…Axonal remodeling is critical to brain repair after stroke. The present study investigated axonal outgrowth after stroke and the signaling pathways mediating…”
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Niacin treatment of stroke increases synaptic plasticity and axon growth in rats by Cui, Xu, Chopp, Michael, Zacharek, Alex, Roberts, Cynthia, Buller, Benjamin, Ion, Madalina, Chen, Jieli

“…Niacin is the most effective medication in current clinical use for increasing high-density lipoprotein cholesterol. We tested the hypothesis that niacin…”
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Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse by Zhang, Rui L, Chopp, Michael, Gregg, Sara R, Toh, Yier, Roberts, Cindi, LeTourneau, Yvonne, Buller, Benjamin, Jia, Longfei, Davarani, Siamak P Nejad, Zhang, Zheng G

“…The migratory behavior of neuroblasts after a stroke is poorly understood. Using time-lapse microscopy, we imaged migration of neuroblasts and cerebral vessels…”
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Neural recovery after cortical injury: Effects of MSC derived extracellular vesicles on motor circuit remodeling in rhesus monkeys by Calderazzo, Samantha, Covert, Margaret, Alba, Diego De, Bowley, Bethany E., Pessina, Monica A., Rosene, Douglas L., Buller, Benjamin, Medalla, Maria, Moore, Tara L.

“…Reorganization of motor circuits in the cortex and corticospinal tract are thought to underlie functional recovery after cortical injury, but the mechanisms of…”
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MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats by Xin, Hongqi, Katakowski, Mark, Wang, Fengjie, Qian, Jian-Yong, Liu, Xian Shuang, Ali, Meser M., Buller, Benjamin, Zhang, Zheng Gang, Chopp, Michael

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Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury by Zhang, Zheng Gang, Buller, Benjamin, Chopp, Michael

“…Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and their families, but currently no drugs on the market promote…”
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MicroRNA cluster miR-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats by Xin, Hongqi, Katakowski, Mark, Wang, Fengjie, Qian, Jian-Yong, Liu, Xian Shuang, Ali, Meser M, Buller, Benjamin, Zhang, Zheng Gang, Chopp, Michael

“…BACKGROUND AND PURPOSE—Multipotent mesenchymal stromal cell (MSC) harvested exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the…”
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MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke by Xin, Hongqi, Liu, Zhongwu, Buller, Benjamin, Li, Yanfeng, Golembieski, William, Gan, Xinling, Wang, Fengjie, Lu, Mei, Ali, Meser M, Zhang, Zheng G, Chopp, Michael

“…MiR-17-92 cluster enriched exosomes derived from multipotent mesenchymal stromal cells (MSCs) increase functional recovery after stroke. Here, we investigate…”
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Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock by Williams, Aaron M, Dennahy, Isabel S, Bhatti, Umar F, Halaweish, Ihab, Xiong, Ye, Chang, Panpan, Nikolian, Vahagn C, Chtraklin, Kiril, Brown, Jordana, Zhang, Yanlu, Zhang, Zheng Gang, Chopp, Michael, Buller, Benjamin, Alam, Hasan B

“…Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) remains a leading cause of preventable death worldwide. Mesenchymal stem cell-derived exosomes…”
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Early single-dose treatment with exosomes provides neuroprotection and improves blood-brain barrier integrity in swine model of traumatic brain injury and hemorrhagic shock by Williams, Aaron M., Bhatti, Umar F., Brown, Jordana F., Biesterveld, Ben E., Kathawate, Ranganath G., Graham, Nathan J., Chtraklin, Kiril, Siddiqui, Ali Z., Dekker, Simone E., Andjelkovic, Anuska, Higgins, Gerald A., Buller, Benjamin, Alam, Hasan B.

“…Administration of human mesenchymal stem cell (MSC)-derived exosomes can enhance neurorestoration in models of traumatic brain injury (TBI) and hemorrhagic…”
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Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex by Medalla, Maria, Chang, Wayne, Calderazzo, Samantha M, Go, Veronica, Tsolias, Alexandra, Goodliffe, Joseph W, Pathak, Dhruba, De Alba, Diego, Pessina, Monica, Rosene, Douglas L, Buller, Benjamin, Moore, Tara L

“…Functional recovery after cortical injury, such as stroke, is associated with neural circuit reorganization, but the underlying mechanisms and efficacy of…”
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Abstract TMP26: Extracellular Vesicles and Myelin Plasticity After Cortical Injury in Non-Human Primates by Go, Veronica, Sarikaya, Deniz, Medalla, Maria, Rosene, Douglas, Buller, Benjamin, Moore, Tara

“…Abstract only Introduction: Our laboratory demonstrated that monkeys treated after cortical injury with extracellular vesicles (EVs) derived from Mesenchymal…”
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Early Transfusion with Mesenchymal Stem Cell Derived Extracellular Vesicles: A New Transfusion Strategy for Life-Threatening Hemorrhage and Traumatic Brain Injury by Dekker, Simone E, Bambakidis, Ted, Williams, Aaron M, Biesterveld, Ben, Bhatti, Umar, Li, Yongqing, Pickell, Zachary, Buller, Benjamin, Alam, Hasan B

“…Background: Life-threatening hemorrhage and traumatic brain injury (TBI) have a significantly increasing global burden and remain leading causes of preventable…”
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Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation by Buller, Benjamin, Chopp, Michael, Ueno, Yuji, Zhang, Li, Zhang, Rui Lan, Morris, Daniel, Zhang, Yi, Zhang, Zheng Gang

“…Serum response factor (SRF) is a transcription factor that transactivates actin‐associated genes and has been implicated in oligodendrocyte (OL)…”
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Abstract TP141: Mesenchymal Stem Cell Derived Exosomes as a Modulator of Neuroinflammation Following Cortical Injury by Go, Veronica, Bowley, Bethany, Rosene, Douglas, Medalla, Maria, Buller, Benjamin, Moore, Tara

“…Abstract only In this study, we tested Mesenchymal Stem Cell derived exosomes as a therapeutic to enhance recovery in our established nonhuman primate model of…”
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