Search Results - "BUISINE, Eric"

The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance by Dubar, Faustine, Egan, Timothy J, Pradines, Bruno, Kuter, David, Ncokazi, Kanyile K, Forge, Delphine, Paul, Jean-François, Pierrot, Christine, Kalamou, Hadidjatou, Khalife, Jamal, Buisine, Eric, Rogier, Christophe, Vezin, Hervé, Forfar, Isabelle, Slomianny, Christian, Trivelli, Xavier, Kapishnikov, Sergey, Leiserowitz, Leslie, Dive, Daniel, Biot, Christophe

“…Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot…”
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2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase from Trypanosoma cruzi:  Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity by SALMON-CHEMIN, Laurence, BUISINE, Eric, YARDLEY, Vanessa, KOHLER, Sven, DEBREU, Marie-Ange, LANDRY, Valérie, SERGHERAERT, Christian, CROFT, Simon L., KRAUTH-SIEGEL, R. Luise, DAVIOUD-CHARVET, Elisabeth

“…Trypanothione reductase (TR) is both a valid and an attractive target for the design of new trypanocidal drugs. Starting from menadione, plumbagin, and…”
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Identification of Amino Acid Residues in the ETS Transcription Factor Erg That Mediate Erg-Jun/Fos-DNA Ternary Complex Formation by Verger, Alexis, Buisine, Eric, Carrère, Séverine, Wintjens, René, Flourens, Anne, Coll, Jean, Stéhelin, Dominique, Duterque-Coquillaud, Martine

“…Jun, Fos, and Ets proteins belong to distinct families of transcription factors that target specific DNA elements often found jointly in gene promoters…”
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Identification of Inhibitors of an 80 kDa Protease from Trypanosoma cruzi through the Screening of a Combinatorial Peptide Library by VENDEVILLE, Sandrine, BUISINE, Eric, WILLIARD, Xavier, SCHREVEL, Joseph, GRELLIER, Philippe, SANTANA, Jaime, SERGHERAERT, Christian

“…Two orthogonal peptide combinatorial libraries were screened to discover inhibitors of Tc80 protease, a novel target from Trypanosoma cruzi involved in host…”
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Investigation of the Redox Behavior of Ferroquine, a New Antimalarial by Chavain, Natascha, Vezin, Hervé, Dive, Daniel, Touati, Nadia, Paul, Jean-François, Buisine, Eric, Biot, Christophe

“…Ferroquine (FQ or SR97193) is a unique ferrocene antimalarial drug candidate which just entered phase IIb clinical trials in autumn 2007. FQ is able to…”
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Identification of Inhibitors of an 80kDa Protease from Trypanosoma cruzi through the Screening of a Combinatorial Peptide Library by VENDEVILLE, Sandrine, BUISINE, Eric, WILLIARD, Xavier, SCHREVEL, Joseph, GRELLIER, Philippe, SANTANA, Jaime, SERGHERAERT, Christian

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Contribution of cation-pi interactions to the stability of protein-DNA complexes by Wintjens, R, Liévin, J, Rooman, M, Buisine, E

“…Cation-pi interactions between an aromatic ring and a positive charge located above it have proven to be important in protein structures and biomolecule…”
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Cation–π/H-bond Stair Motifs at Protein–DNA Interfaces by Rooman, Marianne, Liévin, Jacky, Buisine, Eric, Wintjens, René

“…H-bonds and cation–π interactions between nucleic acid bases and amino acid side-chains are known to occur often concomitantly at the interface between protein…”
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Free-Energy Calculations of Protein−Ligand Cation−π and Amino−π Interactions: From Vacuum to Proteinlike Environments by Biot, Christophe, Buisine, Eric, Rooman, Marianne

“…To probe the role of cation−π and amino−π interactions in the context of protein−ligand interactions, the stability of 55 X-ray cation/amino−π motifs involving…”
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Solvent-Induced Effects:  Self-Association of Positively Charged π Systems by Buisine, Eric, de Villiers, Katherine, Egan, Timothy J, Biot, Christophe

“…Antimalarial cationic drugs, such as chloroquine (CQ) and ferroquine (FQ), form stable dimer structures not only in the solid state but also in solution. The…”
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Structural Analysis of an Unusual Bioactive N-Acylated Lipo-Oligosaccharide LOS-IV in Mycobacterium marinum by Rombouts, Yoann, Elass, Elisabeth, Biot, Christophe, Maes, Emmanuel, Coddeville, Bernadette, Burguière, Adeline, Tokarski, Caroline, Buisine, Eric, Trivelli, Xavier, Kremer, Laurent, Guérardel, Yann

“…Although lipo-oligosaccharides (LOSs) are recognized as major parietal components in many mycobacterial species, their involvement in the host−pathogen…”
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Probing the energetic and structural role of amino acid/nucleobase cation-pi interactions in protein-ligand complexes by Biot, Christophe, Buisine, Eric, Kwasigroch, Jean-Marc, Wintjens, René, Rooman, Marianne

“…X-ray structures of proteins bound to ligand molecules containing a nucleic acid base were systematically searched for cation-pi interactions between the base…”
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Synthesis and crystal structure of 3,5-diacetyl-4-methylpyrazole by Outirite, Moha, Bentiss, Fouad, Buisine, Eric, Capet, Frédéric, Lagrenée, Michel

“…The 3,5‐diacetyl‐4‐methylpyrazole diketone has been synthesized and its crystal structure has been determined. This diketone reacts with hydroxylamine…”
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Spectroscopic Studies of Diketoacids−Metal Interactions. A Probing Tool for the Pharmacophoric Intermetallic Distance in the HIV-1 Integrase Active Site by Maurin, Cédric, Bailly, Fabrice, Buisine, Eric, Vezin, Hervé, Mbemba, Gladys, Mouscadet, Jean François, Cotelle, Philippe

“…The interactions with divalent cations of 4-phenyl-4-oxo-2-hydroxybuten-2-oic acid (benzoylpyruvic acid (BPA)), the pharmacophore of HIV-1 integrase…”
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Development of Novel Statistical Potentials Describing Cation−π Interactions in Proteins and Comparison with Semiempirical and Quantum Chemistry Approaches by Gilis, Dimitri, Biot, Christophe, Buisine, Eric, Dehouck, Yves, Rooman, Marianne

“…Novel statistical potentials derived from known protein structures are presented. They are designed to describe cation−π and amino−π interactions between a…”
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Development of novel statistical potentials describing cation-p interactions in proteins and comparison with semi-empirical and quantum chemistry approaches by Gilis, Dimitri, Biot, Christophe, Buisine, Eric, Dehouck, Yves, Rooman, Marianne

“…Novel statistical potentials derived from known protein structures are presented. They are designed to describe cation- and amino- interactions between a…”
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Probing the Energetic and Structural Role of Amino Acid/Nucleobase Cation-π Interactions in Protein-Ligand Complexes by Christophe Biot, Eric Buisine, Jean-Marc Kwasigroch, René Wintjens, Marianne Rooman

“…X-ray structures of proteins bound to ligand molecules containing a nucleic acid base were systematically searched for cation-π interactions between the base…”
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Contribution of cation-π interactions to the stability of protein-DNA complexes 1 1Edited by J. Thornton by Wintjens, René, Liévin, Jacky, Rooman, Marianne, Buisine, Eric

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Synthesis, folding, and structure of the β-turn mimic modified B1 domain of streptococcal protein G by ODAERT, BENOIT, JEAN, FABIENNE, BOUTILLON, CHRISTOPHE, BUISINE, ERIC, MELNYK, OLEG, TARTAR, ANDRE, LIPPENS, GUY

“…The mechanism of β-sheet formation remains a fundamental issue in our understanding of the protein folding process, but is hampered by the often encountered…”
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2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain by Baillet, Stéphanie, Buisine, Eric, Horvath, Dragos, Maes, Louis, Bonnet, Beatrice, Sergheraert, Christian

“…A molecular modeling study meant to detect pharmacophore-like patterns in the active site of trypanothione reductase (TR) offered hints about the opportunity…”
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