Search Results - "BUETTNER, R"

Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide by Buettner, Garry R

“…Superoxide dismutases (SOD) are considered to be antioxidant enzymes. This view came about because its substrate, superoxide, is a free radical; in the era of…”
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Ascorbic acid: Chemistry, biology and the treatment of cancer by Du, Juan, Cullen, Joseph J., Buettner, Garry R.

“…Since the discovery of vitamin C, the number of its known biological functions is continually expanding. Both the names ascorbic acid and vitamin C reflect its…”
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Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide by Song, Yang, Buettner, Garry R.

“…The quinone/semiquinone/hydroquinone triad (Q/SQ •−/H 2Q) represents a class of compounds that has great importance in a wide range of biological processes…”
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An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses by Spitz, Douglas R., Buettner, Garry R., Petronek, Michael S., St-Aubin, Joël J., Flynn, Ryan T., Waldron, Timothy J., Limoli, Charles L.

“…•FLASH radiation dose-rates consume all the local tissue O2 to form reactive organic hydroperoxides.•Fenton type reactions will be limited in normal vs. cancer…”
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Just another brick in the wall: unravelling the epigenetic mechanism underlying tumour initiation of testicular germ cell cancer by Buettner, R

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Moving free radical and redox biology ahead in the next decade(s) by Buettner, Garry R.

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Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy by Doskey, Claire M., Buranasudja, Visarut, Wagner, Brett A., Wilkes, Justin G., Du, Juan, Cullen, Joseph J., Buettner, Garry R.

“…Ascorbate (AscH − ) functions as a versatile reducing agent. At pharmacological doses (P-AscH − ; [plasma AscH − ] ≥≈20 mM), achievable through intravenous…”
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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple by Schafer, F Q, Buettner, G R

“…Redox state is a term used widely in the research field of free radicals and oxidative stress. Unfortunately, it is used as a general term referring to…”
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The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome by Traber, Maret G, Buettner, Garry R, Bruno, Richard S

“…Metabolic syndrome (MetS) is a constellation of cardiometabolic risk factors, which together predict increased risk of more serious chronic diseases. We…”
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Chitosan gallate as a novel potential polysaccharide antioxidant: an EPR study by Pasanphan, Wanvimol, Buettner, Garry R., Chirachanchai, Suwabun

“…A novel biopolymer-based antioxidant, chitosan conjugated with gallic acid (chitosan galloylate, chitosan–GA), is proposed. Electron paramagnetic resonance…”
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Pharmacologic Ascorbic Acid Concentrations Selectively Kill Cancer Cells: Action as a Pro-Drug to Deliver Hydrogen Peroxide to Tissues by Chen, Qi, Espey, Michael Graham, Krishna, Murali C., Mitchell, James B., Corpe, Christopher P., Buettner, Garry R., Shacter, Emily, Levine, Mark, Rall, J. E.

“…Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment…”
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Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer by Alexander, Matthew S, Wilkes, Justin G, Schroeder, Samuel R, Buettner, Garry R, Wagner, Brett A, Du, Juan, Gibson-Corley, Katherine, O'Leary, Brianne R, Spitz, Douglas R, Buatti, John M, Berg, Daniel J, Bodeker, Kellie L, Vollstedt, Sandy, Brown, Heather A, Allen, Bryan G, Cullen, Joseph J

“…: Chemoradiation therapy is the mainstay for treatment of locally advanced, borderline resectable pancreatic cancer. Pharmacologic ascorbate (P-AscH , i.e.,…”
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An oral multispecies biofilm model for high content screening applications by Kommerein, Nadine, Stumpp, Sascha N, Müsken, Mathias, Ehlert, Nina, Winkel, Andreas, Häussler, Susanne, Behrens, Peter, Buettner, Falk F R, Stiesch, Meike

“…Peri-implantitis caused by multispecies biofilms is a major complication in dental implant treatment. The bacterial infection surrounding dental implants can…”
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Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages by Werneburg, Sebastian, Buettner, Falk F. R., Erben, Larissa, Mathews, Mona, Neumann, Harald, Mühlenhoff, Martina, Hildebrandt, Herbert

“…Microglia are tissue macrophages and mediators of innate immune responses in the brain. The protein‐modifying glycan polysialic acid (polySia) is implicated in…”
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Defining high-fat-diet rat models: metabolic and molecular effects of different fat types by Buettner, R, Parhofer, K G, Woenckhaus, M, Wrede, C E, Kunz-Schughart, L A, Schölmerich, J, Bollheimer, L C

“…High-fat (HF)-diet rodent models have contributed significantly to the analysis of the pathophysiology of the insulin resistance syndrome, but their phenotype…”
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Plasma markers of COVID-19 severity: a pilot study by Beimdiek, Julia, Janciauskiene, Sabina, Wrenger, Sabine, Volland, Sonja, Rozy, Adriana, Fuge, Jan, Olejnicka, Beata, Pink, Isabell, Illig, Thomas, Popov, Alexander, Chorostowska, Joanna, Buettner, Falk F R, Welte, Tobias

“…SARS-CoV-2 infected patients show heterogeneous clinical presentations ranging from mild symptoms to severe respiratory failure and death. Consequently,…”
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Role of labile iron in the toxicity of pharmacological ascorbate by Du, Juan, Wagner, Brett A., Buettner, Garry R., Cullen, Joseph J.

“…Pharmacological ascorbate has been shown to induce toxicity in a wide range of cancer cell lines. Pharmacological ascorbate in animal models has shown promise…”
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Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation by Sprüssel, A, Schulte, J H, Weber, S, Necke, M, Händschke, K, Thor, T, Pajtler, K W, Schramm, A, König, K, Diehl, L, Mestdagh, P, Vandesompele, J, Speleman, F, Jastrow, H, Heukamp, L C, Schüle, R, Dührsen, U, Buettner, R, Eggert, A, Göthert, J R

“…Lysine (K)-specific demethylase 1A (LSD1/KDM1A) has been identified as a potential therapeutic target in solid cancers and more recently in acute myeloid…”
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Immunogenicity of intensively decellularized equine carotid arteries is conferred by the extracellular matrix protein collagen type VI by Boeer, Ulrike, Buettner, Falk F R, Klingenberg, Melanie, Antonopoulos, Georgios C, Meyer, Heiko, Haverich, Axel, Wilhelmi, Mathias

“…The limited biocompatibility of decellularized scaffolds is an ongoing challenge in tissue engineering. Here, we demonstrate the residual immunogenicity of an…”
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Metadherin enhances vulnerability of cancer cells to ferroptosis by Bi, Jianling, Yang, Shujie, Li, Long, Dai, Qun, Borcherding, Nicholas, Wagner, Brett A., Buettner, Garry R., Spitz, Douglas R., Leslie, Kimberly K., Zhang, Jun, Meng, Xiangbing

“…Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death driven by lipid hydroperoxides within biological membranes. Although…”
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