Search Results - "BUEE, L"

Neurotrophic factors in Alzheimer’s disease: role of axonal transport by Schindowski, K., Belarbi, K., Buée, L.

“…Neurotrophic factors (NTF) are small, versatile proteins that maintain survival and function to specific neuronal populations. In general, the axonal transport…”
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Prediction of pathology in primary progressive language and speech disorders by DERAMECOURT, V, LEBERT, F, DEBACHY, B, MACKOWIAK-CORDOLIANI, M. A, BOMBOIS, S, KERDRAON, O, BUEE, L, MAURAGE, C.-A, PASQUIER, F

“…Frontotemporal lobar degeneration (FTLD) encompasses a variety of clinicopathologic entities. The antemortem prediction of the underlying pathologic lesions is…”
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Association of plasma amyloid β with risk of dementia: The prospective Three-City Study by LAMBERT, J.-C, SCHRAEN-MASCHKE, S, AMOUYEL, P, RICHARD, F, FIEVET, N, ROUAUD, O, BERR, C, DARTIGUES, J.-F, TZOURIO, C, ALPEROVITCH, A, BUEE, L

“…Several lines of evidence indicate that a decrease in the CSF concentration of amyloid beta(42) (Abeta(42)) is a potential biomarker for incident Alzheimer…”
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Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology by Chapuis, J, Hansmannel, F, Gistelinck, M, Mounier, A, Van Cauwenberghe, C, Kolen, K V, Geller, F, Sottejeau, Y, Harold, D, Dourlen, P, Grenier-Boley, B, Kamatani, Y, Delepine, B, Demiautte, F, Zelenika, D, Zommer, N, Hamdane, M, Bellenguez, C, Dartigues, J-F, Hauw, J-J, Letronne, F, Ayral, A-M, Sleegers, K, Schellens, A, Broeck, L V, Engelborghs, S, De Deyn, P P, Vandenberghe, R, O'Donovan, M, Owen, M, Epelbaum, J, Mercken, M, Karran, E, Bantscheff, M, Drewes, G, Joberty, G, Campion, D, Octave, J-N, Berr, C, Lathrop, M, Callaerts, P, Mann, D, Williams, J, Buée, L, Dewachter, I, Van Broeckhoven, C, Amouyel, P, Moechars, D, Dermaut, B, Lambert, J-C

“…Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer’s…”
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Current and emerging avenues for Alzheimer's disease drug targets by Loera‐Valencia, R., Cedazo‐Minguez, A., Kenigsberg, P.A., Page, G., Duarte, A.I., Giusti, P., Zusso, M., Robert, P., Frisoni, G. B., Cattaneo, A., Zille, M., Boltze, J., Cartier, N., Buee, L., Johansson, G., Winblad, B.

“…Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a global epidemic, and so far, there is neither cure nor treatment to alter its…”
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The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease by DELACOURTE, A, DAVID, J. P, PETIT, H, DI MENZA, C, SERGEANT, N, BUEE, L, WATTEZ, A, VERMERSCH, P, GHOZALI, F, FALLET-BIANCO, C, PASQUIER, F, LEBERT, F

“…To determine the spatiotemporal mapping of neurofibrillary degeneration (NFD) in normal aging and the different stages of AD. The pathophysiologic significance…”
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The free plasma amyloid Aβ 1 - 42 /Aβ 1 - 40 ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma Aβ 1 - 42 /Aβ 1 - 40 ratio. The BALTAZAR study by Schraen-Maschke, S, Duhamel, A, Vidal, J S, Ramdane, N, Vaudran, L, Dussart, C, Buée, L, Sablonnière, B, Delaby, C, Allinquant, B, Gabelle, A, Bombois, S, Lehmann, S, Hanon, O

“…Blood-based biomarkers are a non-invasive solution to predict the risk of conversion of mild cognitive impairment (MCI) to dementia. The utility of free plasma…”
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Neurogenesis and cell cycle‐reactivated neuronal death during pathogenic tau aggregation by Schindowski, K., Belarbi, K., Bretteville, A., Ando, K., Buée, L.

“…The aim of the present study was to investigate the relation between neurogenesis, cell cycle reactivation and neuronal death during tau pathology in a novel…”
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A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly by Chouraki, V, De Bruijn, R F A G, Chapuis, J, Bis, J C, Reitz, C, Schraen, S, Ibrahim-Verbaas, C A, Grenier-Boley, B, Delay, C, Rogers, R, Demiautte, F, Mounier, A, Fitzpatrick, A L, Berr, C, Dartigues, J-F, Uitterlinden, A G, Hofman, A, Breteler, M, Becker, J T, Lathrop, M, Schupf, N, Alpérovitch, A, Mayeux, R, van Duijn, C M, Buée, L, Amouyel, P, Lopez, O L, Ikram, M A, Tzourio, C, Lambert, J-C

“…Amyloid beta (Aβ) peptides are the major components of senile plaques, one of the main pathological hallmarks of Alzheimer disease (AD). However, Aβ peptides'…”
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Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease by Bensemain, F, Hot, D, Ferreira, S, Dumont, J, Bombois, S, Maurage, C-A, Huot, L, Hermant, X, Levillain, E, Hubans, C, Hansmannel, F, Chapuis, J, Hauw, J-J, Schraen, S, Lemoine, Y, Buée, L, Berr, C, Mann, D, Pasquier, F, Amouyel, P, Lambert, J-C

“…To more rapidly identify candidate genes located within chromosomal regions of interest defined by genome scan studies in Alzheimer's disease (AD), we have…”
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Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP-17 and Pick's Disease by Buée, Luc, Delacourte, André

“…Neurodegenerative disorders referred to as tauopathies have cellular hyperphosphorylated tau protein aggregates in the absence of amyloid deposits. Comparative…”
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Sstr2A: a relevant target for the delivery of genes into human glioblastoma cells using fiber-modified adenoviral vectors by Lécolle, K, Bégard, S, Caillierez, R, Demeyer, D, Grellier, E, Loyens, A, Csaba, Z, Beauvillain, J C, D'Halluin, J C, Baroncini, M, Lejeune, J P, Sharif, A, Prévot, V, Dournaud, P, Buée, L, Colin, M

“…Glioblastomas are the most aggressive of the brain tumors occurring in adults and children. Currently available chemotherapy prolongs the median survival time…”
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Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: Two individual consequences of CUG trinucleotide repeats by Dhaenens, C.M., Schraen-Maschke, S., Tran, H., Vingtdeux, V., Ghanem, D., Leroy, O., Delplanque, J., Vanbrussel, E., Delacourte, A., Vermersch, P., Maurage, C.A., Gruffat, H., Sergeant, A., Mahadevan, M.S., Ishiura, S., Buée, L., Cooper, T.A., Caillet-Boudin, M.L., Charlet-Berguerand, N., Sablonnière, B., Sergeant, N.

“…Neurofibrillary degeneration is often observed in the brain of patients with type 1 myotonic dystrophy (DM1). It consists principally of the aggregation of Tau…”
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Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology by Dourlen, P, Fernandez-Gomez, F J, Dupont, C, Grenier-Boley, B, Bellenguez, C, Obriot, H, Caillierez, R, Sottejeau, Y, Chapuis, J, Bretteville, A, Abdelfettah, F, Delay, C, Malmanche, N, Soininen, H, Hiltunen, M, Galas, M-C, Amouyel, P, Sergeant, N, Buée, L, Lambert, J-C, Dermaut, B

“…A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE ) in which the functional genes are…”
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Proteasome inhibition and Tau proteolysis: an unexpected regulation by Delobel, P., Leroy, O., Hamdane, M., Sambo, A.V., Delacourte, A., Buée, L.

“…Increasing evidence suggests that an inhibition of the proteasome, as demonstrated in Parkinson’s disease, might be involved in Alzheimer’s disease. In this…”
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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders by Buée, Luc, Bussière, Thierry, Buée-Scherrer, Valérie, Delacourte, André, Hof, Patrick R.

“…Tau proteins belong to the family of microtubule-associated proteins. They are mainly expressed in neurons where they play an important role in the assembly of…”
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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 by Duff, Karen, Eckman, Chris, Zehr, Cindy, Yu, Xin, Prada, Cristian-Mihail, Perez-tur, Jordi, Hutton, Mike, Buee, Luc, Harigaya, Yasuo, Yager, Debra, Morgan, David, Gordon, Marcia N, Holcomb, Leigh, Refolo, Lawrence, Zenk, Brenda, Hardy, John, Younkin, Steven

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Tau pathology: a marker of neurodegenerative disorders by Delacourte, A, Buée, L

“…Tau is not only a basic component of neurofibrillary degeneration, but is also an aetiological factor, as demonstrated by mutations on the tau gene responsible…”
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Brain Microvascular Changes in Alzheimer's Disease and Other Dementias by BUÉE, LUC, HOF, PATRICK R., DELACOURTE, ANDRÉ

“…Vasculopathy in Alzheimer's disease (AD) may represent an important pathogenetic factor of this disorder. In the present study, microvasculature was studied by…”
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Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model by Brouillette, J., Caillierez, R., Zommer, N., Alves-Pires, C., Benilova, I., Blum, D., De Strooper, B., Buee, L.

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