Search Results - "BUDINI, Mauricio"

Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72 by Budini, Mauricio, Buratti, Emanuele, Morselli, Eugenia, Criollo, Alfredo

“…Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures called autophagolysosomes. Autophagy is necessary to…”
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Chaperone Mediated Autophagy Substrates and Components in Cancer by Rios, Javiera, Sequeida, Alvaro, Albornoz, Amelina, Budini, Mauricio

“…Chaperone-mediated autophagy (CMA) represents a specific way of lysosomal protein degradation and contrary to macro and microautophagy is independent of…”
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TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain by Budini, Mauricio, Romano, Valentina, Quadri, Zainuddin, Buratti, Emanuele, Baralle, Francisco E

“…TDP-43 aggregates are the neurohistological landmark of diseases like amyotrophic lateral sclerosis and frontotemporal dementia. Their role in the pathogenesis…”
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Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders by Alfaro, Iván E, Albornoz, Amelina, Molina, Alfredo, Moreno, José, Cordero, Karina, Criollo, Alfredo, Budini, Mauricio

“…Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process…”
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Cellular Model of TAR DNA-binding Protein 43 (TDP-43) Aggregation Based on Its C-terminal Gln/Asn-rich Region by Budini, Mauricio, Buratti, Emanuele, Stuani, Cristiana, Guarnaccia, Corrado, Romano, Valentina, De Conti, Laura, Baralle, Francisco E.

“…TDP-43 is one of the major components of the neuronal and glial inclusions observed in several neurodegenerative diseases such as amyotrophic lateral sclerosis…”
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Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation by Ormeño, Fernando, Hormazabal, Juan, Moreno, José, Riquelme, Felipe, Rios, Javiera, Criollo, Alfredo, Albornoz, Amelina, Alfaro, Iván E, Budini, Mauricio

“…TAR DNA binding protein 43 kDa (TDP-43) is a ribonuclear protein regulating many aspects of RNA metabolism. Amyotrophic Lateral Sclerosis (ALS) and…”
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Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation by Albornoz, Nicolás, Álvarez-Indo, Javiera, de la Peña, Adely, Arias-Muñoz, Eloisa, Coca, Alanis, Segovia-Miranda, Fabián, Kerr, Bredford, Budini, Mauricio, Criollo, Alfredo, García-Robles, María A, Morselli, Eugenia, Soza, Andrea, Burgos, Patricia V

“…Obesity represents a significant global health challenge characterized by chronic low-grade inflammation and metabolic dysregulation. The hypothalamus, a key…”
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Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism by Ávalos, Yenniffer, Hernández-Cáceres, María Paz, Lagos, Pablo, Pinto-Nuñez, Daniela, Rivera, Patricia, Burgos, Paulina, Díaz-Castro, Francisco, Joy-Immediato, Michelle, Venegas-Zamora, Leslye, Lopez-Gallardo, Erik, Kretschmar, Catalina, Batista-Gonzalez, Ana, Cifuentes-Araneda, Flavia, Toledo-Valenzuela, Lilian, Rodriguez-Peña, Marcelo, Espinoza-Caicedo, Jasson, Perez-Leighton, Claudio, Bertocchi, Cristina, Cerda, Mauricio, Troncoso, Rodrigo, Parra, Valentina, Budini, Mauricio, Burgos, Patricia V., Criollo, Alfredo, Morselli, Eugenia

“…Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed chronically with a high-fat diet (HFD). PA impairs insulin signaling in…”
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Autophagy in aging-related oral diseases by Peña-Oyarzún, Daniel, San Martin, Carla, Hernández-Cáceres, María Paz, Lavandero, Sergio, Morselli, Eugenia, Budini, Mauricio, Burgos, Patricia V., Criollo, Alfredo

“…Autophagy is an intracellular degradation mechanism that allows recycling of organelles and macromolecules. Autophagic function increases metabolite…”
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Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye by Cragnaz, Lucia, Klima, Raffaela, Skoko, Natasa, Budini, Mauricio, Feiguin, Fabian, Baralle, Francisco E

“…Abstract TDP-43 inclusions are an important histopathological feature in various neurodegenerative disorders, including Amyotrophic Lateral Sclerosis and…”
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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis by Torres, Alfredo, Michea, M. Angélica, Végvári, Ákos, Arce, Marion, Pérez, Valentina, Alcota, Marcela, Morales, Alicia, Vernal, Rolando, Budini, Mauricio, Zubarev, Roman A., González, Fermín E.

“…Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases, yet its association with progressive periodontitis remains unexplored…”
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Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen by Huang, Ya-Lin, De Gregorio, Cristian, Silva, Verónica, Elorza, Álvaro A, Léniz, Patricio, Aliaga-Tobar, Víctor, Maracaja-Coutinho, Vinicius, Budini, Mauricio, Ezquer, Fernando, Ezquer, Marcelo

“…Drug-induced liver injury (DILI) is one of the leading causes of acute liver injury. While many factors may contribute to the susceptibility to DILI, obese…”
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Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation by Budini, Mauricio, Romano, Valentina, Avendaño-Vázquez, S. Eréndira, Bembich, Sara, Buratti, Emanuele, Baralle, Francisco E

“…Abstract The overview of TDP 43 functions immediately disclose a number of open questions regarding its pathological role. The formation of TDP-43 aggregates…”
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Origanum vulgare L. essential oil inhibits virulence patterns of Candida spp. and potentiates the effects of fluconazole and nystatin in vitro by Cid-Chevecich, Camila, Müller-Sepúlveda, Andrea, Jara, José Antonio, López-Muñoz, Rodrigo, Santander, Rocío, Budini, Mauricio, Escobar, Alejandro, Quijada, Raúl, Criollo, Alfredo, Díaz-Dosque, Mario, Molina-Berríos, Alfredo

“…Recurrence and resistance of Candida spp. infections is associated with the ability of these microorganisms to present several virulence patterns such as…”
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Polycystin-2 Is Required for Starvation- and Rapamycin-Induced Atrophy in Myotubes by Kretschmar, Catalina, Peña-Oyarzun, Daniel, Hernando, Cecilia, Hernández-Moya, Nadia, Molina-Berríos, Alfredo, Hernández-Cáceres, María Paz, Lavandero, Sergio, Budini, Mauricio, Morselli, Eugenia, Parra, Valentina, Troncoso, Rodrigo, Criollo, Alfredo

“…Muscle atrophy involves a massive catabolism of intracellular components leading to a significant reduction in cellular and tissue volume. In this regard,…”
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Editorial: Selective and secretory autophagy pathways and molecules in the prevention and treatment of complex endocrine-metabolic diseases of aging by Vaccaro, Maria Ines, Gonzalez, Claudio Daniel, De Tata, Vincenzo, Quarleri, Jorge, Budini, Mauricio Fernando

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Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro by Espinosa, Rodrigo, Gutiérrez, Karla, Rios, Javiera, Ormeño, Fernando, Yantén, Liliana, Galaz-Davison, Pablo, Ramírez-Sarmiento, César A, Parra, Valentina, Albornoz, Amelina, Alfaro, Iván E, Burgos, Patricia V, Morselli, Eugenia, Criollo, Alfredo, Budini, Mauricio

“…The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as…”
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TDP-43 Autoregulation: Implications for Disease by Budini, Mauricio, Buratti, Emanuele

“…TDP-43 is a nuclear protein that has been shown to play a central role in RNA metabolism. In recent years, this protein has become very important in the study…”
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Poly(GP) proteins: a potential pharmacodynamic marker in ALS and FTD by Budini, Mauricio, Criollo, Alfredo

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Hyperosmotic stress stimulates autophagy via polycystin-2 by Peña-Oyarzun, Daniel, Troncoso, Rodrigo, Kretschmar, Catalina, Hernando, Cecilia, Budini, Mauricio, Morselli, Eugenia, Lavandero, Sergio, Criollo, Alfredo

“…Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes…”
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